Task Progress:
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SUPPLEMENTAL REPORTING FOR FINAL REPORT (March 2015)
This study is complete. The findings from the Nutrition SMO have shed light on a number of metabolic issues that are important for human long-duration space flight. Given the comprehensive nature of the Nutritional Status Assessment protocol, there are likely many lessons to be learned, beyond those already identified. These data will be a valuable resource for years to come.
Sample collection protocols were well executed, and samples were returned on Space Shuttle and SpaceX flights. 32 subjects completed the protocol. Individual data briefings have been provided to all available crewmembers. Findings have been briefed to the Human Health and Performance Directorate, the Human Research Program (HRP) and its Human Health Countermeasures Element, and the International Space Station Medical Project. Data have been published in peer-reviewed journals, presented at the HRP Investigators’ Workshop, and have been presented at national and international scientific meetings. A recent update to the nutrition evidence report, published in book form, includes large amounts of Nutrition SMO data (Smith SM, Zwart SR, Heer M. Human Adaptation to Spaceflight: The Role of Nutrition (NP-2014-10-018-JSC). Houston, TX: National Aeronautics and Space Administration Lyndon B. Johnson Space Center; 201) (available through open access at http://www.nasa.gov/sites/default/files/human-adaptation-to-spaceflight-the-role-of-nutrition.pdf ; http://go.nasa.gov/QS1KW1 ). Data have been shared with other investigators, per data sharing agreements and documentation, and the database transferred to the Life Sciences Data Archive.
ANNUAL REPORT FROM JULY 2014
As of July 2014, 32 subjects have completed the protocol, and all samples have been returned to Earth from ISS. Some analyses are pending, and should be completed in the coming months. Individual data briefings have been provided to most crewmembers. Preliminary findings have been briefed to the Space Life Sciences Directorate, the Human Research Program (HRP) and its Human Health Countermeasures Element, and the International Space Station Medical Project, and have been presented at the HRP Investigators’ Workshop. Preliminary data have also been published in peer-reviewed journals, and presented at national and international scientific meetings, and transferred to the Life Sciences Data Archive.
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Articles in Peer-reviewed Journals
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Smith SM, Zwart SR, Heer M, Hudson EK, Shackelford L, Morgan JL. "Men and women in space: bone loss and kidney stone risk after long-duration space flight." J Bone Miner Res. 2014 Jul;29(7):1639-45. http://dx.doi.org/10.1002/jbmr.2185 ; PubMed PMID: 24470067 , Jul-2014
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Articles in Peer-reviewed Journals
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Crucian BE, Zwart SR, Mehta S, Uchakin P, Quiriarte HD, Pierson D, Sams CF, Smith SM. "Plasma cytokine concentrations indicate that in-vivo hormonal regulation of immunity is altered during long-duration spaceflight." J Interferon Cytokine Res. 2014 Oct;34(10):778-86. http://dx.doi.org/10.1089/jir.2013.0129 ; PubMed PMID: 24702175 ; PubMed Central PMCID: PMC4186776 (originally reported as Epub 2014 Apr 4) , Oct-2014
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Articles in Peer-reviewed Journals
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Zwart SR, Launius R, Coen GK, Charles JB, Smith SM. "Body mass changes during long-duration spaceflight." Aviat Space Environ Med. 2014 Sep;85:897-904. http://dx.doi.org/10.3357/ASEM.3979.2014 ; PMID: 25197887 , Sep-2014
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Articles in Peer-reviewed Journals
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Smith SM, Abrams SA, Davis-Street JE, Heer M, O'Brien KO, Wastney ME, Zwart SR. "50 years of human space travel: implications for bone and calcium research." Annu Rev Nutr. 2014 Jul 17;34:377-400. http://dx.doi.org/10.1146/annurev-nutr-071813-105440 ; PubMed PMID: 24995691 , Jul-2014
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Articles in Peer-reviewed Journals
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Smith SM, Zwart SR. "Magnesium and space flight." Nutrients. 2015 Dec 8;7(12):10209-22. http://dx.doi.org/10.3390/nu7125528 ; PubMed PMID: 26670248; PubMed Central PMCID: PMC4690080 , Dec-2015
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Articles in Peer-reviewed Journals
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Smith SM, Castaneda-Sceppa C, O'Brien KO, Abrams SA, Gillman P, Brooks NE, Cloutier GJ, Heer M, Zwart SR, Wastney ME. "Calcium kinetics during bed rest with artificial gravity and exercise countermeasures." Osteoporos Int. 2014 Sep;25(9):2237-44. Epub 2014 May 27. http://dx.doi.org/10.1007/s00198-014-2754-x ; PubMed PMID: 24861908; PubMed Central PMCID: PMC4521405 , Sep-2014
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Articles in Peer-reviewed Journals
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Smith SM, Heer M, Shackelford LC, Sibonga JD, Spatz J, Pietrzyk RA, Hudson EK, Zwart SR. "Bone metabolism and renal stone risk during International Space Station missions." Bone. 2015 Dec;81:712-20. Epub 2015 Oct 8. https://doi.org/10.1016/j.bone.2015.10.002 ; PubMed PMID: 26456109 , Dec-2015
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Articles in Peer-reviewed Journals
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Heacox HN, Gillman PL, Zwart SR, Smith SM. "Excretion of zinc and copper increases in men during 3 weeks of bed rest, with or without artificial gravity." J Nutr. 2017 Jun;147(6):1113-20. https://doi.org/10.3945/jn.117.247437 ; PMID: 28490676; PMCID: PMC5443469 , Jun-2017
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Articles in Peer-reviewed Journals
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Patel ZS, Brunstetter TJ, Tarver WJ, Whitmire AM, Zwart SR, Smith SM, Huff JL. "Red risks for a journey to the red planet: The highest priority human health risks for a mission to Mars." npj Microgravity. 2020 Nov 5;6(1):33. Review. https://doi.org/10.1038/s41526-020-00124-6 ; PMID: 33298950; PMCID: PMC7645687 , Nov-2020
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Articles in Peer-reviewed Journals
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Frings-Meuthen P, Luchitskaya E, Jordan J, Tank J, Lichtinghagen R, Smith SM, Heer M. "Natriuretic peptide resetting in astronauts." Circulation. 2020 May 12;141(19):1593-5. https://doi.org/10.1161/CIRCULATIONAHA.119.044203 ; PMID: 32392103 , May-2020
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Books/Book Chapters
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Heer M, Titze J, Smith SM, Baecker N. "Nutrition, physiology and metabolism in spaceflight and analog studies." Cham, Switzerland: Springer, 2015. 69 p. http://dx.doi.org/10.1007/978-3-319-18521-7 , Jul-2015
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Books/Book Chapters
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Smith SM, Heer M, Zwart SR. "Nutrition and Bone Health in Space." in "Nutrition and Bone Health, 2nd ed." Ed. M. Holick, J. Nieves. New York : Springer, 2015. p. 687-705. http://dx.doi.org/10.1007/978-1-4939-2001-3_41 (originally reported as 'in press, as of July 2014.')., Jan-2015
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NASA Technical Documents
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Smith SM, Zwart SR, Heer M. "Human Adaptation to Spaceflight: The Role of Nutrition." Houston, TX : National Aeronautics and Space Administration Lyndon B. Johnson Space Center, 2014. (NP-2014-10-018-JSC). ISBN:9780160926297. http://www.nasa.gov/sites/default/files/human-adaptation-to-spaceflight-the-role-of-nutrition.pdf ; accessed 3/31/2015. , Dec-2014
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NASA Technical Documents
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Smith SM, Zwart SR, Douglas GL, Heer M. "Human adaptation to spaceflight: The role of food and nutrition. Second edition." Houston, TX: NASA Lyndon B. Johnson Space Center, 2021. 255 p. NP-2021-03-003-JSC. https://www.nasa.gov/sites/default/files/atoms/files/human_adaptation_2021_final.pdf , Apr-2021
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