Task Progress:
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It was recently established that immune dysregulation occurs during spaceflight (Crucian 2012 JCI) and persists for the duration of a 6 month ISS mission (Crucian et al., and Mehta et al., NASA HRP Workshop, February 2013). During exploration class space missions, immune dysregulation may pose a unique clinical health risk to astronauts. A validated ground analog for this in-flight phenomenon would have utility for basic research and possible countermeasures evaluation. It has been speculated that Antarctica winterover may be a potential analog for in-flight immune dysregulation.
Among all Antarctica bases, it is thought that Concordia Station might serve as the closest analog to exploration class deep space missions. This is due to the extremely harsh environment in the Antarctic interior (much worse than coastal stations), and the spaceflight-similar environment/lifestyle experienced at Concordia Station (referring to both interior station lifestyle and the exterior EVA conditions). The intent of this study was to assess immunity, viral reactivation, stress and adverse clinical outcomes during Antarctica winterover at Concordia Station. These parameters have been shown to be significantly altered during spaceflight (HRP reference). The battery of assays was similar to those used for the Integrated Immune flight study, to therefore allow a straightforward comparison of in-flight and overwinter data. Due to fortuitous scheduling, the flight and ground studies actually operated in parallel. Integrated Immune ISS astronauts were actually able to hold teleconferences with winterover participants at Concordia Station.
Following study completion and full sample analysis, the data showed that immune system changes did manifest during the overwinter period at Concordia Station. These changes consisted of alterations in the distribution of the peripheral blood immune cells, alterations in the plasma concentration of various cytokines (proteins that regulate immunity), alterations in T cell function. Parallel with the alterations in immunity, the consistent reactivation of latent herpesviruses was observed, as was alterations in various stress hormones. The circadian rhythm of the overwinter participants also appeared to be misaligned. An increase in constitutively activated T cells is thought to correlate with in-vivo immune activation or illness. During winterover, an increase in activated T cells was observed only during early deployment, which correlated with clinical incidence data showing at least three periods of endemic clinical illness. These overall clinical findings correlate perfectly with the elevation in constitutively activated T cells for the CHOICE subjects.
NASA study data was presented at the NASA HRP Investigators' Workshop, February 2012 and February 2013. Joint NASA-ESA investigator meetings were held in early 2013 to review all participant data (both NASA and ESA), and a publication strategy was planned for this data set.
References
B. E. Crucian, S. Mehta, R. P. Stowe, P. Uchakin, H. Quiriarte, D. Pierson, C. F. Sams. Immune System Dysregulation Persists During Long-Duration Spaceflight. 2013 Human Research Program Investigators Workshop, Galveston, Texas, February 11-14, 2013.
S. K. Mehta, B. E. Crucian, R. P. Stowe, C. Sams, V. A. Castro, C. M. Ott, and D. L. Pierson. Viral reactivation in the International Space Station Crew. 2013 Human Research Program Investigators Workshop, Galveston, Texas, February 11-14, 2013.
B. Crucian, A. Chouker, R. Stowe, S. Mehta, A. Salam, M. Feuerecker, H. Quiriarte, D. Pierson, C. Sams. Immune dysregulation and latent viral reactivation during winterover at Concordia Station, Dome C, Antarctica. NASA Human Research Program Investigators' Workshop. Houston, Texas, February 14-16, 2012.
Brian Crucian, Raymond Stowe, Satish Mehta, Peter Uchakin, Heather Quiriarte, Duane Pierson and Clarence Sams. Immune System Dysregulation Occurs During Short Duration Spaceflight On Board the Space Shuttle. Journal of Clinical Immunology (Published online ahead of print, October 2012).
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Abstracts for Journals and Proceedings
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Crucian BE, Mehta S, Stowe RP, Uchakin P, Quiriarte H, Pierson D, Sams CF. "Immune System Dysregulation Persists During Long-Duration Spaceflight." 2013 NASA Human Research Program Investigators’ Workshop, Galveston, TX, February 12-14, 2013. 2013 NASA Human Research Program Investigators’ Workshop, Galveston, TX, February 12-14, 2013. , Feb-2013
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Abstracts for Journals and Proceedings
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Mehta S, Crucian BE, Stowe RP, Sams CF, Castro VA, Ott CM, Pierson D. "Viral reactivation in the International Space Station Crew." 2013 NASA Human Research Program Investigators’ Workshop, Galveston, TX, February 12-14, 2013. 2013 NASA Human Research Program Investigators’ Workshop, Galveston, TX, February 12-14, 2013. , Feb-2013
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Articles in Peer-reviewed Journals
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Feuerecker M, Crucian B, Salam AP, Rybka A, Kaufmann I, Moreels M, Quintens R, Schelling G, Thiel M, Baatout S, Sams C, Choukèr A. "Early adaption to the Antarctic environment at dome C: consequences on stress-sensitive innate immune functions." High Alt Med Biol. 2014 Sep;15(3):341-8. Epub 2014 Aug 6. https://doi.org/10.1089/ham.2013.1128 ; PubMed PMID: 25099674 , Sep-2014
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Articles in Peer-reviewed Journals
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Feuerecker M, Crucian BE, Quintens R, Buchheim JI, Salam AP, Rybka A, Moreels M, Strewe C, Stowe R, Mehta S, Schelling G, Thiel M, Baatout S, Sams C, Choukér A. "Immune sensitization during one year in the Antarctic high altitude Concordia environment." Allergy. 2019 Jan;74(1):64-77. Epub 2018 Nov 20. https://doi.org/10.1111/all.13545 ; PubMed PMID: 29978486 , Jan-2019
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Articles in Peer-reviewed Journals
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Feuerecker M, Strewe C, Aumayr M, Heitland T, Limper U, Crucian B, Baatout S, Choukér A. "One year in the extreme isolation of Antarctica-Is this enough to modulate an "allergic" sensitization?" Biomedicines. 2022 Feb 15;10(2):448. https://doi.org/10.3390/biomedicines10020448 ; PMID: 35203657; PMCID: PMC8962425 , Feb-2022
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Articles in Peer-reviewed Journals
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Crucian B, Stowe R, Mehta S, Uchakin P, Quiriarte H, Pierson D, Sams C. "Immune system dysregulation occurs during short duration spaceflight on board the space shuttle." Journal of Clinical Immunology. 2013 Feb;33(2):456-65. Epub 2012 Oct 26. http://dx.doi.org/10.1007/s10875-012-9824-7 ;
PubMed PMID: 2310014 , Feb-2013
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