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Project Title:  Integrated Physiological Responses of CNS and Muscle in Drosophila and C. elegans Along a Gravity Continuum Reduce
Images: icon  Fiscal Year: FY 2022 
Division: Space Biology 
Research Discipline/Element:
Space Biology: Cell & Molecular Biology   | Animal Biology: Invertebrate  
Start Date: 01/01/2022  
End Date: 12/31/2024  
Task Last Updated: 01/04/2022 
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Principal Investigator/Affiliation:   Ocorr, Karen  Ph.D. / Sanford Burnham Prebys Medical Discovery Institute 
Address:  Center for Genetic Disorders and Aging Research 
10901 N Torrey Pines Rd 
La Jolla , CA 92037-1005 
Phone: 858-692-0051  
Congressional District: 49 
Organization Type: NON-PROFIT 
Organization Name: Sanford Burnham Prebys Medical Discovery Institute 
Joint Agency:  
Iyer, Janani  Ph.D. NASA Ames Research Center 
Szewczyk, Nathaniel  Ph.D. Ohio University 
Costes, Sylvain  Ph.D. NASA Ames Research Center 
Mhatre, Siddhita  Ph.D. NASA Ames Research Center 
Project Information: Grant/Contract No. 80NSSC22K0278 
Responsible Center: NASA ARC 
Grant Monitor: Griko, Yuri  
Center Contact: 650-604-0519 
Solicitation / Funding Source: 2020 Space Biology NNH20ZDA001N-SB E.12. Flight/Ground Research 
Grant/Contract No.: 80NSSC22K0278 
Project Type: FLIGHT,GROUND 
Flight Program: ISS 
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Space Biology Element: (1) Cell & Molecular Biology
(2) Animal Biology: Invertebrate
Space Biology Cross-Element Discipline: (1) Musculoskeletal Biology
(2) Neurobiology
Space Biology Special Category: None
Task Description: Our studies will use the fruit fly Drosophila and the worm Caenorhabditis elegans (C. elegans) to identify conserved mechanisms underlying the oxidative stress response to altered gravity. Spaceflight induces alterations in somatic/cardiac muscle, as well as in the brain. Many of these changes mirror those induced by long-term bed-rest on Earth and with age. We will use functional, structural, and molecular biological techniques to identify common genetic and molecular components that mediate the effect of microgravity, lunar gravity, and Mars gravity on organ function. The use of two different genetic model organisms will allow us to identify common targets across species that can be exploited to mitigate negative health effects of long duration space habitation and perhaps provide therapies to combat muscle wasting and neurodegeneration on Earth. We will also compare the changes in these organisms with published changes in humans subjected to bed-rest and spaceflight.

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Task Progress & Bibliography Information FY2022 
Task Progress: New project for FY2022.

Bibliography Type: Description: (Last Updated: ) 

Show Cumulative Bibliography Listing
 None in FY 2022