• The iSAFE Principal Investigator (PI) team has continued to work with the NASA Research Operations and Integration (ROI) Element to integrate this project into the Complement of Integrated Protocols for Human Research (CIPHER) studies. This effort included providing inputs to the Scientific Research Document (SRD); the iSAFE SRD is now baselined for all mission durations: Short, Standard, and Extended.
• The Test Readiness Review (TRR) document supporting the implementation of the iSAFE Study activities in NASA Johnson Space Center Building 21 was submitted to ROI.
• The iSAFE PI team supported the TRR for the Payloads Development Laboratory (PDL) in NASA Johnson Space Center Building 9, which is now approved. This TRR permits the use of the PDL for training crewmember operators to perform ERGs and pneumatonometry.
• Supported the informed consent briefings (ICB) for 5 potential CIPHER subjects (03/04/2021, 04/29/2021 [x2], 11/15/2021, 12/01/2021) and developed an iSAFE overview video that has been integrated into the CIPHER ICB presentation.
• Supported a hardware checkout of the ERG units designated for flight, flight backup, ground use by ROI, and for baseline data collection.
• ERG and pneumatonometry flight hardware/units passed Science Verification Testing (SVT) and are now on the International Space Station.
• Two iSAFE operators completed Telescience Center orientation in preparation for remote guidance activities, and remote guidance scripts were drafted for ERG and pneumatonometry.
• Completed the Payloads Training Dry Run (PTDR) that was overseen by NASA Marshall Space Flight Center, certifying proficiency of Cardiovascular and Vision Laboratory (CVL) personnel (Co-Investigator Scott Greenwald) to train crewmember operators for ERG and pneumatonometry.
• Two crewmember operators have completed the “Training” sessions for ERG and pneumatonometry (11/03/2021, 11/12/2021).
• Preliminary dry runs of baseline data collection were completed in the NASA Cardiovascular and Vision Laboratory.
• Steps have been taken to ensure readiness for implementation of inflight OCT angiography, which include obtaining the flight version of the OCT software and conducting preliminary remote guidance training for CVL personnel.
• Preliminary training occurred for iSAFE operators on Dynamic Vessel data collection and analysis.
• The plans for iSAFE were presented at the 2021 Human Research Program Investigators’ Workshop and at the JSC Chapter of the NASA Alumni League, both virtual.
• Substantial progress has been made towards finalizing the iSAFE data analysis plan.
• Substantial progress has been made towards finalizing the suite of standard operating procedures (SOPs) and operator logs.