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Project Title:  SPACE-CENT: Studying the Physiological and Anatomical Cerebral Effects of CENTrifugation and Head Down Tilt Bed Rest Reduce
Images: icon  Fiscal Year: FY 2021 
Division: Human Research 
Research Discipline/Element:
HRP HHC:Human Health Countermeasures
Start Date: 01/09/2017  
End Date: 07/31/2021  
Task Last Updated: 09/08/2021 
Download report in PDF pdf
Principal Investigator/Affiliation:   Bershad, Eric M. M.D. / Baylor College of Medicine 
Address:  Department of Neurology, 1 Baylor Plaza 
Section of Vascular Neurology and Neurocritical Care 
Houston , TX 77030-3411 
Email: bershad@bcm.edu 
Phone: 713-504-0223  
Congressional District:
Web:  
Organization Type: UNIVERSITY 
Organization Name: Baylor College of Medicine 
Joint Agency:  
Comments:  
Co-Investigator(s)
Affiliation: 
Clark, Jonathan  M.D. Baylor College of Medicine 
Cohen, Helen  Ed.D. Baylor College of Medicine 
Kramer, Larry  M.D. University of Texas, Houston 
Marshall-Goebel, Karina  Ph.D. KBR/NASA Johnson Space Center 
Rittweger, Joern  M.D. Deutsches Zentrum Fuer Luft- Und Raumfahrt E.V. 
Sangi-Haghpeykar, Haleh  Ph.D. Baylor College of Medicine 
Stern, Claudia  M.D. German Aerospace Cente (DLR) 
Strangman, Gary  Ph.D. Massachusetts General Hospital 
Venkatasubba Rao, Chethan  M.D. Baylor College of Medicine 
Damani, Rahul  M.D. Baylor College of Medicine 
Laurie, Steven  Ph.D. KBR/NASA Johnson Space Center 
Martin, Bryn  Ph.D. University of Idaho 
Key Personnel Changes / Previous PI: November 2019 update: Bryn A. Martin, Ph.D., Associate Professor of Biological Engineering at University of Idaho, added to team. He will apply automated imaging to analysis structural changes of the globe in MRI imaging acquired in our study. This quantitative data will be useful to determine whether the artificial gravity protects the eye from structural changes from the 60 days of 6 degree head down tilt exposure.
Project Information: Grant/Contract No. NNX17AE04G 
Responsible Center: NASA JSC 
Grant Monitor: Stenger, Michael  
Center Contact: 281-483-1311 
michael.b.stenger@nasa.gov 
Solicitation / Funding Source: 2015-16 HERO NNJ15ZSA001N-AGBR. Appendix G: Physiological & Behavioral Responses in Humans to Intermittent Artificial Gravity during Bed Rest 
Grant/Contract No.: NNX17AE04G 
Project Type: GROUND 
Flight Program:  
TechPort: No 
No. of Post Docs:
No. of PhD Candidates:  
No. of Master's Candidates:  
No. of Bachelor's Candidates:  
No. of PhD Degrees:  
No. of Master's Degrees:  
No. of Bachelor's Degrees:  
Human Research Program Elements: (1) HHC:Human Health Countermeasures
Human Research Program Risks: (1) SANS:Risk of Spaceflight Associated Neuro-ocular Syndrome (IRP Rev I)
(2) Sensorimotor:Risk of Altered Sensorimotor/Vestibular Function Impacting Critical Mission Tasks (Revised as of IRP Rev M)
Human Research Program Gaps: (1) SANS-303:Efficiency of artificial gravity (centrifugation)-induced fluid shift versus other mechanical means (IRP Rev L)
(2) SM-101:Characterize the effects of short and long-duration weightlessness, with and without deep-space radiation, on postural control and locomotion (gross motor control) after g transitions. Critical mission tasks: Ability to stand upright without falling, ability to walk safely without tripping or stumbling, ability to quickly egress from a vehicle, etc. (IRP Rev L)
Flight Assignment/Project Notes: NOTE: Extended to 7/31/2021 per L. Barnes-Moten/JSC and NSSC information (Ed., 3/18/21)

NOTE: Extended to 3/31/2021 per D. Risin/JSC and NSSC information (Ed., 8/26/20)

NOTE: Extended to 9/30/2020 per NSSC information (Ed., 10/18/19)

Task Description: This project will assess the physiological and anatomical effects of two different regimens of intermittent centrifugation induced artificial gravity (AG) with focus on the brain, eye, and vestibular system responses.

The specific aims include: 1. Integrative evaluation of the cerebral physiological effects of AG during the 60 day bed rest period using between group and within group comparisons, and 2. Assessment of the acute dynamic changes in the human body systems related to the centrifugation regimen.

The methods and techniques used to achieve these objectives include: non-invasive assessment of ICP (intracranial pressure), cerebral blood flow, cerebral blood volume, CSF (cerebrospinal fluid) flow and volumes, ocular anatomy and physiology, and neurovestibular function.

This proposal will deliver an integrated view of the physiological, anatomical, and functional effects of intermittent centrifugation (artificial gravity) on the cerebrovascular, ocularm, and vestibular systems. This will provide important insights into the effectiveness of this form of artificial gravity to counteract the headward fluid shifting of head down tilt, which may yield important knowledge about the future utility of this method as a countermeasure for the spaceflight-induced headward fluid shifts and the Spaceflight Associated Neuro-ocular Syndrome (SANS).

Research Impact/Earth Benefits: This project will implement a wide array of non-invasive monitoring technologies for the brain, vascular system, eye, and sensorimotor system. Some of these technologies are commercially available for Earth based medicine in a variety of health care settings including the intensive care unit, emergency room, and may be implementable in rural and/or remote settings, and could be monitored by clinicians via telemedicine.

Task Progress & Bibliography Information FY2021 
Task Progress: The following key tasks were accomplished in 2020-2021:

1) Completion of subject enrollment and procedures. 24 of 24 total subjects were enrolled with successful completion of all study procedures

2) Data analysis completed for the eye measures including:

- Optical coherence tomography based total retinal nerve fiber layer thickness; - Optical biometry; - Intraocular pressure; - Chorioretinal folds and thickness; - Refractive error; - Automated perimetry derived axial length; - Posterior globe flattening; - Eye movement measurements

3. Data analysis completed for the following brain measures:

- Near infrared spectroscopy derived cerebral blood volumes, arterial blood pulsatility

- MRI structural measures including lateral ventricular volumes, total brain volume

- MRI flow measures included CSF flow, cerebral arterial flow

- Transcranial doppler derived cerebral blood flow velocities and cerebral autoregulation

- cFLOW cerebral blood flow index

- Internal jugular vein cross sectional areas.

Several manuscripts are under preparation for posterior globe deformation, near infrared spectroscopy, internal jugular vein area, transcranial Doppler blood flow, and MRI brain.

Bibliography Type: Description: (Last Updated: 09/10/2021)  Show Cumulative Bibliography Listing
 
Articles in Peer-reviewed Journals Laurie SS, Greenwald SH, Marshall-Goebel K, Pardon LP, Gupta A, Lee SMC, Stern C, Sangi-Haghpeykar H, Macias BR, Bershad EM. "Optic disc edema and chorioretinal folds develop during strict 6° head-down tilt bed rest with or without artificial gravity." Physiol Rep. 2021 Aug 6;9(15):e14977. https://doi.org/10.14814/phy2.14977 ; PMID: 34355874; PMCID: PMC8343460 , Aug-2021
Project Title:  SPACE-CENT: Studying the Physiological and Anatomical Cerebral Effects of CENTrifugation and Head Down Tilt Bed Rest Reduce
Images: icon  Fiscal Year: FY 2020 
Division: Human Research 
Research Discipline/Element:
HRP HHC:Human Health Countermeasures
Start Date: 01/09/2017  
End Date: 03/31/2021  
Task Last Updated: 11/07/2019 
Download report in PDF pdf
Principal Investigator/Affiliation:   Bershad, Eric M. M.D. / Baylor College of Medicine 
Address:  Department of Neurology, 1 Baylor Plaza 
Section of Vascular Neurology and Neurocritical Care 
Houston , TX 77030-3411 
Email: bershad@bcm.edu 
Phone: 713-504-0223  
Congressional District:
Web:  
Organization Type: UNIVERSITY 
Organization Name: Baylor College of Medicine 
Joint Agency:  
Comments:  
Co-Investigator(s)
Affiliation: 
Clark, Jonathan  M.D. Baylor College of Medicine 
Cohen, Helen  Ed.D. Baylor College of Medicine 
Kramer, Larry  M.D. University of Texas, Houston 
Marshall-Goebel, Karina  Ph.D. KBR/NASA Johnson Space Center 
Rittweger, Joern  M.D. Deutsches Zentrum Fuer Luft- Und Raumfahrt E.V. 
Sangi-Haghpeykar, Haleh  Ph.D. Baylor College of Medicine 
Stern, Claudia  M.D. German Aerospace Cente (DLR) 
Strangman, Gary  Ph.D. Massachusetts General Hospital 
Venkatasubba Rao, Chethan  M.D. Baylor College of Medicine 
Damani, Rahul  M.D. Baylor College of Medicine 
Laurie, Steven  Ph.D. KBR/NASA Johnson Space Center 
Key Personnel Changes / Previous PI: November 2019 update: Bryn A. Martin, Ph.D., Associate Professor of Biological Engineering at University of Idaho, added to team. He will apply automated imaging to analysis structural changes of the globe in MRI imaging acquired in our study. This quantitative data will be useful to determine whether the artificial gravity protects the eye from structural changes from the 60 days of 6 degree head down tilt exposure.
Project Information: Grant/Contract No. NNX17AE04G 
Responsible Center: NASA JSC 
Grant Monitor: Norsk, Peter  
Center Contact:  
Peter.norsk@nasa.gov 
Solicitation / Funding Source: 2015-16 HERO NNJ15ZSA001N-AGBR. Appendix G: Physiological & Behavioral Responses in Humans to Intermittent Artificial Gravity during Bed Rest 
Grant/Contract No.: NNX17AE04G 
Project Type: GROUND 
Flight Program:  
TechPort: No 
No. of Post Docs:
No. of PhD Candidates:  
No. of Master's Candidates:  
No. of Bachelor's Candidates:  
No. of PhD Degrees:  
No. of Master's Degrees:  
No. of Bachelor's Degrees:  
Human Research Program Elements: (1) HHC:Human Health Countermeasures
Human Research Program Risks: (1) SANS:Risk of Spaceflight Associated Neuro-ocular Syndrome (IRP Rev I)
(2) Sensorimotor:Risk of Altered Sensorimotor/Vestibular Function Impacting Critical Mission Tasks (Revised as of IRP Rev M)
Human Research Program Gaps: (1) SANS-303:Efficiency of artificial gravity (centrifugation)-induced fluid shift versus other mechanical means (IRP Rev L)
(2) SM-101:Characterize the effects of short and long-duration weightlessness, with and without deep-space radiation, on postural control and locomotion (gross motor control) after g transitions. Critical mission tasks: Ability to stand upright without falling, ability to walk safely without tripping or stumbling, ability to quickly egress from a vehicle, etc. (IRP Rev L)
Flight Assignment/Project Notes: NOTE: Extended to 3/31/2021 per D. Risin/JSC and NSSC information (Ed., 8/26/20)

NOTE: Extended to 9/30/2020 per NSSC information (Ed., 10/18/19)

Task Description: This project will assess the physiological and anatomical effects of two different regimens of intermittent centrifugation induced artificial gravity (AG) with focus on the brain, eye, and vestibular system responses.

The specific aims include: 1. Integrative evaluation of the cerebral physiological effects of AG during the 60 day bed rest period using between group and within group comparisons, and 2. Assessment of the acute dynamic changes in the human body systems related to the centrifugation regimen.

The methods and techniques used to achieve these objectives include: non-invasive assessment of ICP (intracranial pressure), cerebral blood flow, cerebral blood volume, CSF (cerebrospinal fluid) flow and volumes, ocular anatomy and physiology, and neurovestibular function.

This proposal will deliver an integrated view of the physiological, anatomical, and functional effects of intermittent centrifugation (artificial gravity) on the cerebrovascular, ocularm, and vestibular systems. This will provide important insights into the effectiveness of this form of artificial gravity to counteract the headward fluid shifting of head down tilt, which may yield important knowledge about the future utility of this method as a countermeasure for the spaceflight-induced headward fluid shifts and the Spaceflight Associated Neuro-ocular Syndrome (SANS).

Research Impact/Earth Benefits: This project will implement a wide array of non-invasive monitoring technologies for the brain, vascular system, eye, and sensorimotor system. Some of these technologies are commercially available for Earth based medicine in a variety of health care settings including the intensive care unit, emergency room, and may be implementable in rural and/or remote settings, and could be monitored by clinicians via telemedicine.

Task Progress & Bibliography Information FY2020 
Task Progress: Subject recruitment for campaign 1 of 2 was successful, and all 12 enrolled subjects completed the study and all procedures. Campaign 2 is currently underway, and expected to complete by the end of 2019.

The following procedures were successfully conducted in all participants with no major technical issues: Transcranial doppler, cerebral perfusion monitoring (cFLOW), near infrared spectroscopy, internal jugular vein ultrasound, optical coherence tomography, intraocular pressure, optical biometry, visual acuity, visual field testing, cycloplegic refraction, field testing (sit-to-stand, recovery from fall, jump down test, standing on foam, tandem walk), iPAS (eye movements), MRI: brain and eye structure, CSF flow, cerebral blood flow, globe imaging, and transcutaneous CO2 measurement during sleep.

Data analysis will be ongoing until study completion September 2020.

Bibliography Type: Description: (Last Updated: 09/10/2021)  Show Cumulative Bibliography Listing
 
 None in FY 2020
Project Title:  SPACE-CENT: Studying the Physiological and Anatomical Cerebral Effects of CENTrifugation and Head Down Tilt Bed Rest Reduce
Images: icon  Fiscal Year: FY 2019 
Division: Human Research 
Research Discipline/Element:
HRP HHC:Human Health Countermeasures
Start Date: 01/09/2017  
End Date: 09/30/2020  
Task Last Updated: 10/25/2018 
Download report in PDF pdf
Principal Investigator/Affiliation:   Bershad, Eric M. M.D. / Baylor College of Medicine 
Address:  Department of Neurology, 1 Baylor Plaza 
Section of Vascular Neurology and Neurocritical Care 
Houston , TX 77030-3411 
Email: bershad@bcm.edu 
Phone: 713-504-0223  
Congressional District:
Web:  
Organization Type: UNIVERSITY 
Organization Name: Baylor College of Medicine 
Joint Agency:  
Comments:  
Co-Investigator(s)
Affiliation: 
Clark, Jonathan  M.D. Baylor College of Medicine 
Cohen, Helen  Ed.D. Baylor College of Medicine 
Kramer, Larry  M.D. University of Texas, Houston 
Marshall-Goebel, Karina  Ph.D. NASA Johnson Space Center 
Rittweger, Joern  M.D. Deutsches Zentrum Fuer Luft- Und Raumfahrt E.V. 
Sangi-Haghpeykar, Haleh  Ph.D. Baylor College of Medicine 
Stern, Claudia  M.D. German Aerospace Cente (DLR) 
Strangman, Gary  Ph.D. Massachusetts General Hospital 
Venkatasubba Rao, Chethan  M.D. Baylor College of Medicine 
Damani, Rahul  M.D. Baylor College of Medicine 
Laurie, Steven  Ph.D. NASA Johnson Space Center 
Key Personnel Changes / Previous PI: October 2018 report: Addition of several personnel including Steven Laurie from NASA and his laboratory to assist with in depth optical coherence tomography (OCT) analysis given the positive results from the VaPER study. Addition of Rahul Damani, neurocritical care at Baylor College of Medicine (BCM), and removal of Jose Suarez who changed institutions.
Project Information: Grant/Contract No. NNX17AE04G 
Responsible Center: NASA JSC 
Grant Monitor: Norsk, Peter  
Center Contact:  
Peter.norsk@nasa.gov 
Solicitation / Funding Source: 2015-16 HERO NNJ15ZSA001N-AGBR. Appendix G: Physiological & Behavioral Responses in Humans to Intermittent Artificial Gravity during Bed Rest 
Grant/Contract No.: NNX17AE04G 
Project Type: GROUND 
Flight Program:  
TechPort: No 
No. of Post Docs:
No. of PhD Candidates:  
No. of Master's Candidates:  
No. of Bachelor's Candidates:  
No. of PhD Degrees:  
No. of Master's Degrees:  
No. of Bachelor's Degrees:  
Human Research Program Elements: (1) HHC:Human Health Countermeasures
Human Research Program Risks: (1) SANS:Risk of Spaceflight Associated Neuro-ocular Syndrome (IRP Rev I)
(2) Sensorimotor:Risk of Altered Sensorimotor/Vestibular Function Impacting Critical Mission Tasks (Revised as of IRP Rev M)
Human Research Program Gaps: (1) SANS-303:Efficiency of artificial gravity (centrifugation)-induced fluid shift versus other mechanical means (IRP Rev L)
(2) SM-101:Characterize the effects of short and long-duration weightlessness, with and without deep-space radiation, on postural control and locomotion (gross motor control) after g transitions. Critical mission tasks: Ability to stand upright without falling, ability to walk safely without tripping or stumbling, ability to quickly egress from a vehicle, etc. (IRP Rev L)
Flight Assignment/Project Notes: NOTE: Extended to 9/30/2020 per NSSC information (Ed., 10/18/19)

Task Description: This project will assess the physiological and anatomical effects of two different regimens of intermittent centrifugation induced artificial gravity (AG) with focus on the brain, eye, and vestibular system responses.

The specific aims include: 1. Integrative evaluation of the cerebral physiological effects of AG during the 60 day bed rest period using between group and within group comparisons, and 2. Assessment of the acute dynamic changes in the human body systems related to the centrifugation regimen.

The methods and techniques used to achieve these objectives include: non-invasive assessment of ICP (intracranial pressure), cerebral blood flow, cerebral blood volume, CSF (cerebrospinal fluid) flow and volumes, ocular anatomy and physiology, and neurovestibular function.

This proposal will deliver an integrated view of the physiological, anatomical, and functional effects of intermittent centrifugation (artificial gravity) on the cerebrovascular, ocularm, and vestibular systems. This will provide important insights into the effectiveness of this form of artificial gravity to counteract the headward fluid shifting of head down tilt, which may yield important knowledge about the future utility of this method as a countermeasure for the space-flight induced headward fluid shifts and the Spaceflight Associated Neuro-ocular Syndrome (SANS).

Research Impact/Earth Benefits: This project will implement a wide array of non-invasive monitoring technologies for the brain, vascular system, eye, and sensorimotor system. Some of these technologies are commercially available for Earth based medicine in a variety of health care settings including the intensive care unit, emergency room, and may be implementable in rural and/or remote settings, and could be monitored by clinicians via telemedicine.

Task Progress & Bibliography Information FY2019 
Task Progress: The spaceflight environment is associated with both temporary and some permanent changes to the vision and shape of eye structures in astronauts, which are likely related to the effect of microgravity (i.e., weightlessness) on the eye and brain. This syndrome is named Spaceflight Associated Neuroocular Syndrome (SANS) and is thought to be related to fluid redistribution into the head related to the upward shifting of fluids in microgravity.

Development of a ground based analog is essential to understanding the anatomical and physiological processes that may be occurring in the spaceflight environment, and will also allow for the development of countermeasures to reduce the adverse effects of microgravity. Our project is designed to monitor the brain and eye changes occurring in a bed rest analog that combines 6 degree head down tilt with an artificial gravity countermeasure using short-arm centrifugation.

In the current phase, the devices and methods for testing have been determined. The devices were selected both for ease of use, non-invasive and safe, and monitoring important physiological parameters of the brain and/or eye.

A dry run was successfully completed in Cologne, Germany at the German Aerospace Center in September 2018. The devices were tested on a test subject on the centrifuge and the measurements confirmed fluid redistribution from the head to the legs when the artificial gravity was active. Good quality physiological signals were obtainable, and efficiencies for combining several devices simultaneously were found. This will allow for more efficient testing of the healthy subjects during the study phase, and also allow for better understanding of the physiological changes as assessed by multiple modalities in real time.

The tentative start of the 60 day bedrest study is March 2019.

Bibliography Type: Description: (Last Updated: 09/10/2021)  Show Cumulative Bibliography Listing
 
Abstracts for Journals and Proceedings Bershad EM, Venkatasubba Rao CV, Lazaridis C, Cohen HS, Clark JB, Sangi-Haghpeykar HS, Suarez, JI, Strangman GE, Marshall-Goebel K, Kramer LA, Hasan KM, Stern C, Rittweger J. "SPACE-CENT: Studying the Physiological and Anatomical Effects of Centrifugation and Head Down Tilt." Presented at the 2018 NASA Human Research Program Investigators’ Workshop, Galveston, TX, January 22-25, 2018.

2018 NASA Human Research Program Investigators’ Workshop, Galveston, TX, January 22-25, 2018. , Jan-2018

Project Title:  SPACE-CENT: Studying the Physiological and Anatomical Cerebral Effects of CENTrifugation and Head Down Tilt Bed Rest Reduce
Images: icon  Fiscal Year: FY 2018 
Division: Human Research 
Research Discipline/Element:
HRP HHC:Human Health Countermeasures
Start Date: 01/09/2017  
End Date: 01/08/2019  
Task Last Updated: 11/09/2017 
Download report in PDF pdf
Principal Investigator/Affiliation:   Bershad, Eric M. M.D. / Baylor College of Medicine 
Address:  Department of Neurology, 1 Baylor Plaza 
Section of Vascular Neurology and Neurocritical Care 
Houston , TX 77030-3411 
Email: bershad@bcm.edu 
Phone: 713-504-0223  
Congressional District:
Web:  
Organization Type: UNIVERSITY 
Organization Name: Baylor College of Medicine 
Joint Agency:  
Comments:  
Co-Investigator(s)
Affiliation: 
Clark, Jonathan  M.D. Baylor College of Medicine 
Cohen, Helen  Ed.D. Baylor College of Medicine 
Kramer, Larry  M.D. University of Texas, Houston 
Marshall-Bowman, Karina  M.S. Deutsches Zentrum Fuer Luft- Und Raumfahrt E.V. 
Rittweger, Joern  M.D. Deutsches Zentrum Fuer Luft- Und Raumfahrt E.V. 
Sangi-Haghpeykar, Haleh  Ph.D. Baylor College of Medicine 
Stern, Claudia  M.D. German Aerospace Cente (DLR) 
Strangman, Gary  Ph.D. Massachusetts General Hospital 
Suarez, Jose  M.D. Baylor College of Medicine 
Venkatasubba Rao, Chethan  M.D. Baylor College of Medicine 
Project Information: Grant/Contract No. NNX17AE04G 
Responsible Center: NASA JSC 
Grant Monitor: Norsk, Peter  
Center Contact:  
Peter.norsk@nasa.gov 
Solicitation / Funding Source: 2015-16 HERO NNJ15ZSA001N-AGBR. Appendix G: Physiological & Behavioral Responses in Humans to Intermittent Artificial Gravity during Bed Rest 
Grant/Contract No.: NNX17AE04G 
Project Type: GROUND 
Flight Program:  
TechPort: No 
No. of Post Docs:
No. of PhD Candidates:  
No. of Master's Candidates:  
No. of Bachelor's Candidates:  
No. of PhD Degrees:  
No. of Master's Degrees:  
No. of Bachelor's Degrees:  
Human Research Program Elements: (1) HHC:Human Health Countermeasures
Human Research Program Risks: (1) SANS:Risk of Spaceflight Associated Neuro-ocular Syndrome (IRP Rev I)
(2) Sensorimotor:Risk of Altered Sensorimotor/Vestibular Function Impacting Critical Mission Tasks (Revised as of IRP Rev M)
Human Research Program Gaps: (1) SANS-303:Efficiency of artificial gravity (centrifugation)-induced fluid shift versus other mechanical means (IRP Rev L)
(2) SM-101:Characterize the effects of short and long-duration weightlessness, with and without deep-space radiation, on postural control and locomotion (gross motor control) after g transitions. Critical mission tasks: Ability to stand upright without falling, ability to walk safely without tripping or stumbling, ability to quickly egress from a vehicle, etc. (IRP Rev L)
Task Description: This project will assess the physiological and anatomical effects of two different regimens of intermittent centrifugation induced artificial gravity (AG) with focus on the brain, eye, and vestibular system responses.

The specific aims include: 1. Integrative evaluation of the cerebral physiological effects of AG during the 60 day bed rest period using between group and within group comparisons, and 2. Assessment of the acute dynamic changes in the human body systems related to the centrifugation regimen.

The methods and techniques used to achieve these objectives include: non-invasive assessment of ICP (intracranial pressure), cerebral blood flow, cerebral blood volume, CSF (cerebrospinal fluid) flow and volumes, ocular anatomy and physiology, and neurovestibular function.

This proposal will deliver an integrated view of the physiological, anatomical, and functional effects of intermittent centrifugation (artificial gravity) on the cerebrovascular, ocularm, and vestibular systems. This will provide important insights into the effectiveness of this form of artificial gravity to counteract the headward fluid shifting of head down tilt, which may yield important knowledge about the future utility of this method as a countermeasure for the space-flight induced headward fluid shifts and the Spaceflight Associated Neuro-ocular Syndrome (SANS).

Research Impact/Earth Benefits: This project will implement a wide array of non-invasive monitoring technologies for the brain, vascular system, eye, and sensorimotor system. Some of these technologies are commercially available for Earth based medicine in a variety of health care settings including the intensive care unit, emergency room, and may be implementable in rural and/or remote settings, and could be monitored by clinicians via telemedicine.

Task Progress & Bibliography Information FY2018 
Task Progress: The study received research board approval by the NASA Institutional Review Board (IRB) as well as the Baylor IRB.

Integration of this study with other US and European teams is proceeding well, and efficiencies between studies integrated into the uniform platform at enhivab (German Aerospace Center) are being identified.

The study methodology will be presented at NASA Human Research Program Investigators' workshop in Jan 2018.

Dry run is tentatively scheduled for late spring/early summer 2018 in Cologne, Germany.

Bibliography Type: Description: (Last Updated: 09/10/2021)  Show Cumulative Bibliography Listing
 
 None in FY 2018
Project Title:  SPACE-CENT: Studying the Physiological and Anatomical Cerebral Effects of CENTrifugation and Head Down Tilt Bed Rest Reduce
Images: icon  Fiscal Year: FY 2017 
Division: Human Research 
Research Discipline/Element:
HRP HHC:Human Health Countermeasures
Start Date: 01/09/2017  
End Date: 01/08/2019  
Task Last Updated: 03/27/2017 
Download report in PDF pdf
Principal Investigator/Affiliation:   Bershad, Eric M. M.D. / Baylor College of Medicine 
Address:  Department of Neurology, 1 Baylor Plaza 
Section of Vascular Neurology and Neurocritical Care 
Houston , TX 77030-3411 
Email: bershad@bcm.edu 
Phone: 713-504-0223  
Congressional District:
Web:  
Organization Type: UNIVERSITY 
Organization Name: Baylor College of Medicine 
Joint Agency:  
Comments:  
Co-Investigator(s)
Affiliation: 
Clark, Jonathan  M.D. Baylor College of Medicine 
Cohen, Helen  Ed.D. Baylor College of Medicine 
Kramer, Larry  M.D. University of Texas, Houston 
Marshall-Bowman, Karina  M.S. Deutsches Zentrum Fuer Luft- Und Raumfahrt E.V. 
Rittweger, Joern  M.D. Deutsches Zentrum Fuer Luft- Und Raumfahrt E.V. 
Sangi-Haghpeykar, Haleh  Ph.D. Baylor College of Medicine 
Stern, Claudia  M.D. German Aerospace Cente (DLR) 
Strangman, Gary  Ph.D. Massachusetts General Hospital 
Suarez, Jose  M.D. Baylor College of Medicine 
Venkatasubba Rao, Chethan  M.D. Baylor College of Medicine 
Project Information: Grant/Contract No. NNX17AE04G 
Responsible Center: NASA JSC 
Grant Monitor: Norsk, Peter  
Center Contact:  
Peter.norsk@nasa.gov 
Solicitation / Funding Source: 2015-16 HERO NNJ15ZSA001N-AGBR. Appendix G: Physiological & Behavioral Responses in Humans to Intermittent Artificial Gravity during Bed Rest 
Grant/Contract No.: NNX17AE04G 
Project Type: GROUND 
Flight Program:  
TechPort: No 
No. of Post Docs:  
No. of PhD Candidates:  
No. of Master's Candidates:  
No. of Bachelor's Candidates:  
No. of PhD Degrees:  
No. of Master's Degrees:  
No. of Bachelor's Degrees:  
Human Research Program Elements: (1) HHC:Human Health Countermeasures
Human Research Program Risks: (1) SANS:Risk of Spaceflight Associated Neuro-ocular Syndrome (IRP Rev I)
(2) Sensorimotor:Risk of Altered Sensorimotor/Vestibular Function Impacting Critical Mission Tasks (Revised as of IRP Rev M)
Human Research Program Gaps: (1) SANS-303:Efficiency of artificial gravity (centrifugation)-induced fluid shift versus other mechanical means (IRP Rev L)
(2) SM-101:Characterize the effects of short and long-duration weightlessness, with and without deep-space radiation, on postural control and locomotion (gross motor control) after g transitions. Critical mission tasks: Ability to stand upright without falling, ability to walk safely without tripping or stumbling, ability to quickly egress from a vehicle, etc. (IRP Rev L)
Task Description: This proposal outlines the plan for monitoring the physiological and anatomical effects of two different regimens of intermittent centrifugation induced artificial gravity (AG) with focus on the brain, eye, and vestibular system responses.

The specific aims will include: 1. Integrative evaluation of the cerebral physiological effects of AG during the 60 day bed rest period using between group and within group comparisons, and 2. Assessment of the acute dynamic changes in the human body systems related to the centrifugation regimen.

The methods and techniques used to achieve these objectives include: non-invasive assessment of ICP (intracranial pressure), cerebral blood flow, cerebral blood volume, CSF (cerebral spinal fluid) flow and volumes, ocular anatomy and physiology, and neurovestibular function.

This proposal will deliver an integrated view of the physiological, anatomical and functional effects of intermittent centrifugation (artificial gravity) on the cerebrovascular, ocularm and vestibular systems. This will provide important insights into the effectiveness of this form of artificial gravity to counteract the headward fluid shifting of head down tilt, which may yield important knowledge about the future utility of this method as a countermeasure for the space-flight induced headward fluid shifts and the visual impairment/intracranial pressure (VIIP) syndrome.

Research Impact/Earth Benefits:

Task Progress & Bibliography Information FY2017 
Task Progress: New project for FY2017.

Bibliography Type: Description: (Last Updated: 09/10/2021)  Show Cumulative Bibliography Listing
 
 None in FY 2017