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Project Title:  Integrated Resistance and Aerobic Exercise Training With Small Compact Exercise Equipment Reduce
Fiscal Year: FY 2016 
Division: Human Research 
Research Discipline/Element:
HRP HHC:Human Health Countermeasures
Start Date: 09/01/2012  
End Date: 06/30/2016  
Task Last Updated: 11/07/2016 
Download report in PDF pdf
Principal Investigator/Affiliation:   Ploutz-Snyder, Lori L. Ph.D. / University of Michigan 
Address:  OBL 4170, 1402 Washington Hts. 
School of Kinesiology 
Ann Arbor , MI 48109-2013 
Email: lorips@umich.edu 
Phone: (734) 764-5210  
Congressional District: 12 
Web:  
Organization Type: UNIVERSITY 
Organization Name: University of Michigan 
Joint Agency:  
Comments: Previously at Universities Space Research Association/NASA Johnson Space Center until July 2016.  
Co-Investigator(s)
Affiliation: 
Haddad, Fadia  University of California, Irvine 
Caiozzo, Vincent  University of California, Irvine 
Adams, Gregory  University of California, Irvine 
Ryder, Jeffrey  Universities Space Research Association 
Scott, Jessica  Universities Space Research Association 
Dillon, Edgar  The University of Texas Medical Branch 
Project Information: Grant/Contract No. NCC 9-58-MA02801 
Responsible Center: NSBRI 
Grant Monitor:  
Center Contact:   
Solicitation / Funding Source: 2011 Crew Health NNJ11ZSA002NA 
Grant/Contract No.: NCC 9-58-MA02801 
Project Type: GROUND 
Flight Program:  
TechPort: No 
No. of Post Docs:
No. of PhD Candidates:
No. of Master's Candidates:
No. of Bachelor's Candidates:
No. of PhD Degrees:
No. of Master's Degrees:
No. of Bachelor's Degrees:
Human Research Program Elements: (1) HHC:Human Health Countermeasures
Human Research Program Risks: (1) Aerobic:Risk of Reduced Physical Performance Capabilities Due to Reduced Aerobic Capacity
(2) Muscle:Risk of Impaired Performance Due to Reduced Muscle Mass, Strength and Endurance
(3) Osteo:Risk Of Early Onset Osteoporosis Due To Spaceflight (No longer used, July 2020)
Human Research Program Gaps: (1) A09:Identify and validate exploration countermeasure hardware for the maintenance of VO2 standards (IRP Rev G)
(2) M07:Develop the most efficient exercise program for maintenance of muscle fitness (IRP Rev F)
(3) M09:Identify and validate exploration hardware for maintenance of muscle fitness (IRP Rev F)
(4) Osteo05:We need an inflight capability to monitor bone turnover and bone mass changes during spaceflight (IRP Rev E)
(5) Osteo07:We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight (IRP Rev E)
Flight Assignment/Project Notes: NOTE: End date changed to 6/30/2016 per NSBRI (Ed., 6/29/16)

NOTE: End date changed to 8/31/2016 per October 2014 NSBRI report submission (Ed., 10/22/14)

Task Description: This proposal aims to validate in an analog setting a small compact exercise device for the protection of cardiovascular, muscle, and bone health. This study leverages both currently funded National Space Biomedical Research Institute (NSBRI) and NASA work to bring together for the first time, a promising new exercise device and exercise prescription thus placing this study at a high countermeasure readiness level (moving from 6-7). More specifically, the NSBRI funded M-MED device uses a flywheel to provide loading for either high force-low repetition resistance exercise or low force-high repetition, endurance exercise (rowing). Recent data support M-MED training effectiveness in both ambulatory subjects and over 10 days of muscle unloading using unilateral lower limb suspension model. Accordingly, a new NASA funded exercise prescription study integrating resistance and aerobic training (iRAT) has been effective in the preservation of muscle and cardiovascular function over 14 days of bedrest, but requires the use of 5 different exercise machines. This proposal will combine the M-MED exercise device and the iRAT exercise prescription into a 70 day bedrest study. Outcome measurements related to cardiovascular, muscle and bone health will be obtained and integrated to assess countermeasure effectiveness.

Research Impact/Earth Benefits: Research Impact: The comparison of a single exercise device to an International Space Station-like suite of exercise devices will inform long duration exploration exercise hardware requirements as well as provide a proof of concept of a exercise efficacy using a single device.

Earth Benefits: Developing the most efficient exercise prescription is valuable to a wide population who seek to optimize the health benefits of exercise using as little time as possible. The validation of novel compact exercise hardware may also be useful for other situation where space constraints limit the availability of large scale exercise equipment.

Task Progress & Bibliography Information FY2016 
Task Progress: Final report. Study complete; manuscripts being prepared. Muscle biopsy analyses continue at University of California Irvine.

Bibliography Type: Description: (Last Updated: 05/28/2021)  Show Cumulative Bibliography Listing
 
Articles in Peer-reviewed Journals Ploutz-Snyder LL, Downs M, Goetchius E, Crowell B, English KL, Ploutz-Snyder R, Ryder JW, Dillon EL, Sheffield-Moore M, Scott JM. "Exercise training mitigates multi-system deconditioning during bed rest." Med Sci Sports Exerc. 2018 Sep;50(9):1920-8. https://doi.org/10.1249/MSS.0000000000001618 ; PubMed PMID: 29924746 , Sep-2018
Articles in Peer-reviewed Journals English KL, Downs M, Goetchius E, Buxton R, Ryder JW, Ploutz-Snyder R, Guilliams ME, Scott JM, Ploutz-Snyder LL. "High intensity training during spaceflight: Results from the NASA Sprint Study." npj Microgravity. 2020 Aug 18;6(1):21. https://doi.org/10.1038/s41526-020-00111-x ; PMID: 33574275 , Aug-2020
Articles in Peer-reviewed Journals Downs ME, Scott JM, Ploutz-Snyder LL, Ploutz-Snyder R, Goetchius E, Buxton RE, Danesi CP, Randolph KM, Urban RJ, Sheffield-Moore M, Dillon EL. "Exercise and testosterone countermeasures to mitigate metabolic changes during bed rest." Life Sci Space Res. 2020 Aug;26:97-104. https://doi.org/10.1016/j.lssr.2020.03.008 ; PMID: 32718692; PMCID: PMC7387751 , Aug-2020
Articles in Peer-reviewed Journals Scott JM, Downs M, Buxton R, Goetchius E, Crowell B, Ploutz-Snyder R, Hackney KJ, Ryder J, English K, Ploutz-Snyder LL. "Disuse-induced muscle loss and rehabilitation: The National Aeronautics and Space Administration bed rest study." Crit Care Explor. 2020 Dec;2(12):e0269. https://doi.org/10.1097/CCE.0000000000000269 ; PMID: 33251515; PMCID: PMC7688251 , Dec-2020
Project Title:  Integrated Resistance and Aerobic Exercise Training With Small Compact Exercise Equipment Reduce
Fiscal Year: FY 2015 
Division: Human Research 
Research Discipline/Element:
HRP HHC:Human Health Countermeasures
Start Date: 09/01/2012  
End Date: 06/30/2016  
Task Last Updated: 11/04/2015 
Download report in PDF pdf
Principal Investigator/Affiliation:   Ploutz-Snyder, Lori L. Ph.D. / University of Michigan 
Address:  OBL 4170, 1402 Washington Hts. 
School of Kinesiology 
Ann Arbor , MI 48109-2013 
Email: lorips@umich.edu 
Phone: (734) 764-5210  
Congressional District: 12 
Web:  
Organization Type: UNIVERSITY 
Organization Name: University of Michigan 
Joint Agency:  
Comments: Previously at Universities Space Research Association/NASA Johnson Space Center until July 2016.  
Co-Investigator(s)
Affiliation: 
Haddad, Fadia  University of California, Irvine 
Caiozzo, Vincent  University of California, Irvine 
Adams, Gregory  University of California, Irvine 
Ryder, Jeffrey  Universities Space Research Association 
Scott, Jessica  Universities Space Research Association 
Dillon, Edgar  The University of Texas Medical Branch 
Project Information: Grant/Contract No. NCC 9-58-MA02801 
Responsible Center: NSBRI 
Grant Monitor:  
Center Contact:   
Solicitation / Funding Source: 2011 Crew Health NNJ11ZSA002NA 
Grant/Contract No.: NCC 9-58-MA02801 
Project Type: GROUND 
Flight Program:  
No. of Post Docs:
No. of PhD Candidates:
No. of Master's Candidates:
No. of Bachelor's Candidates:
No. of PhD Degrees:
No. of Master's Degrees:
No. of Bachelor's Degrees:
Human Research Program Elements: (1) HHC:Human Health Countermeasures
Human Research Program Risks: (1) Aerobic:Risk of Reduced Physical Performance Capabilities Due to Reduced Aerobic Capacity
(2) Muscle:Risk of Impaired Performance Due to Reduced Muscle Mass, Strength and Endurance
(3) Osteo:Risk Of Early Onset Osteoporosis Due To Spaceflight (No longer used, July 2020)
Human Research Program Gaps: (1) A09:Identify and validate exploration countermeasure hardware for the maintenance of VO2 standards (IRP Rev G)
(2) M07:Develop the most efficient exercise program for maintenance of muscle fitness (IRP Rev F)
(3) M09:Identify and validate exploration hardware for maintenance of muscle fitness (IRP Rev F)
(4) Osteo05:We need an inflight capability to monitor bone turnover and bone mass changes during spaceflight (IRP Rev E)
(5) Osteo07:We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight (IRP Rev E)
Flight Assignment/Project Notes: NOTE: End date changed to 6/30/2016 per NSBRI (Ed., 6/29/16)

NOTE: End date changed to 8/31/2016 per October 2014 NSBRI report submission (Ed., 10/22/14)

Task Description: This proposal aims to validate in an analog setting a small compact exercise device for the protection of cardiovascular, muscle, and bone health. This study leverages both currently funded National Space Biomedical Research Institute (NSRBRI) and NASA work to bring together for the first time, a promising new exercise device and exercise prescription thus placing this study at a high countermeasure readiness level (moving from 6-7). More specifically, the NSBRI funded M-MED device uses a flywheel to provide loading for either high force-low repetition resistance exercise or low force-high repetition, endurance exercise (rowing). Recent data support M-MED training effectiveness in both ambulatory subjects and over 10 days of muscle unloading using unilateral lower limb suspension model. Accordingly, a new NASA funded exercise prescription study integrating resistance and aerobic training (iRAT) has been effective in the preservation of muscle and cardiovascular function over 14 days of bed rest, but requires the use of 5 different exercise machines. This proposal will combine the M-MED exercise device and the iRAT exercise prescription into a 70 day bed rest study. Outcome measurements related to cardiovascular, muscle, and bone health will be obtained and integrated to assess countermeasure effectiveness.

Research Impact/Earth Benefits: Research Impact: The comparison of a single exercise device to an International Space Station-like suite of exercise devices will inform long duration exploration exercise hardware requirements as well as provide a proof of concept of a exercise efficacy using a single device.

Earth Benefits: Developing the most efficient exercise prescription is valuable to a wide population who seek to optimize the health benefits of exercise using as little time as possible. The validation of novel compact exercise hardware may also be useful for other situations where space constraints limit the availability of large scale exercise equipment. The integration of our data with the many other Principal Investigators (PIs) who shared the same bed rest subjects will provide an invaluable opportunity to understand the role of exercise for the prevention of bed rest (i.e., hospital based) deconditioning.

Task Progress & Bibliography Information FY2015 
Task Progress: Subject data collection was completed in December 2014. The control and traditional exercise subjects (Human Health and Countermeasure element funded) data has been statistically analyzed and presented in preliminary form for an internal NASA audience. Results showed excellent protection of maximal aerobic capacity and reasonable protection of the thigh muscle size and performance while calf cross sectional area and performance still show deficits with about 2/3 of the loss mitigated with the exercise program. The muscle biopsy analyses (Adams UC Irvine - NSBRI funded) are underway. Because these are batch analyzed and time consuming, preliminary data are not yet available, but will be forthcoming during this year.

We completed subject bed rest data collection in December 2014. Preliminary performance data were presented at the Human Research Program (HRP) Investigator Workshop in early 2015. All performance data are analyzed with the exception of some individual muscle MRI cross sectional area analyses; these should be completed by the end of calendar year 2015. 2/3 of the loss was mitigated with the exercise program.

Bibliography Type: Description: (Last Updated: 05/28/2021)  Show Cumulative Bibliography Listing
 
 None in FY 2015
Project Title:  Integrated Resistance and Aerobic Exercise Training With Small Compact Exercise Equipment Reduce
Fiscal Year: FY 2014 
Division: Human Research 
Research Discipline/Element:
HRP HHC:Human Health Countermeasures
Start Date: 09/01/2012  
End Date: 08/31/2016  
Task Last Updated: 10/14/2014 
Download report in PDF pdf
Principal Investigator/Affiliation:   Ploutz-Snyder, Lori L. Ph.D. / University of Michigan 
Address:  OBL 4170, 1402 Washington Hts. 
School of Kinesiology 
Ann Arbor , MI 48109-2013 
Email: lorips@umich.edu 
Phone: (734) 764-5210  
Congressional District: 12 
Web:  
Organization Type: UNIVERSITY 
Organization Name: University of Michigan 
Joint Agency:  
Comments: Previously at Universities Space Research Association/NASA Johnson Space Center until July 2016.  
Co-Investigator(s)
Affiliation: 
Haddad, Fadia  University of California, Irvine 
Caiozzo, Vincent  University of California, Irvine 
Adams, Gregory  University of California, Irvine 
Ryder, Jeffrey  Universities Space Research Association 
Scott, Jessica  Universities Space Research Association 
Dillon, Edgar  The University of Texas Medical Branch 
Project Information: Grant/Contract No. NCC 9-58-MA02801 
Responsible Center: NSBRI 
Grant Monitor:  
Center Contact:   
Solicitation / Funding Source: 2011 Crew Health NNJ11ZSA002NA 
Grant/Contract No.: NCC 9-58-MA02801 
Project Type: GROUND 
Flight Program:  
TechPort: No 
No. of Post Docs:
No. of PhD Candidates:
No. of Master's Candidates:
No. of Bachelor's Candidates:
No. of PhD Degrees:
No. of Master's Degrees:
No. of Bachelor's Degrees:
Human Research Program Elements: (1) HHC:Human Health Countermeasures
Human Research Program Risks: (1) Aerobic:Risk of Reduced Physical Performance Capabilities Due to Reduced Aerobic Capacity
(2) Muscle:Risk of Impaired Performance Due to Reduced Muscle Mass, Strength and Endurance
(3) Osteo:Risk Of Early Onset Osteoporosis Due To Spaceflight (No longer used, July 2020)
Human Research Program Gaps: (1) A09:Identify and validate exploration countermeasure hardware for the maintenance of VO2 standards (IRP Rev G)
(2) M07:Develop the most efficient exercise program for maintenance of muscle fitness (IRP Rev F)
(3) M09:Identify and validate exploration hardware for maintenance of muscle fitness (IRP Rev F)
(4) Osteo05:We need an inflight capability to monitor bone turnover and bone mass changes during spaceflight (IRP Rev E)
(5) Osteo07:We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight (IRP Rev E)
Flight Assignment/Project Notes: NOTE: End date changed to 8/31/2016 per October 2014 NSBRI report submission (Ed., 10/22/14)

Task Description: This proposal aims to validate in an analog setting a small compact exercise device for the protection of cardiovascular, muscle, and bone health. This study leverages both currently funded NSRBRI and NASA work to bring together for the first time, a promising new exercise device and exercise prescription thus placing this study at a high countermeasure readiness level (moving from 6-7). More specifically, the NSBRI funded M-MED device uses a flywheel to provide loading for either high force-low repetition resistance exercise or low force-high repetition, endurance exercise (rowing). Recent data support M-MED training effectiveness in both ambulatory subjects and over 10 days of muscle unloading using unilateral lower limb suspension model. Accordingly, a new NASA funded exercise prescription study integrating resistance and aerobic training (iRAT) has been effective in the preservation of muscle and cardiovascular function over 14 days of bedrest, but requires the use of 5 different exercise machines. This proposal will combine the M-MED exercise device and the iRAT exercise prescription into a 70 day bedrest study. Outcome measurements related to cardiovascular, muscle, and bone health will be obtained and integrated to assess countermeasure effectiveness.

Research Impact/Earth Benefits: Research Impact: The comparison of a single exercise device to an International Space Station-like suite of exercise devices will inform long duration exploration exercise hardware requirements as well as provide a proof of concept of an exercise efficacy using a single device.

Earth Benefits: Developing the most efficient exercise prescription is valuable to a wide population who seek to optimize the health benefits of exercise using as little time as possible. The validation of novel compact exercise hardware may also be useful for other situation where space constraints limit the availability of large scale exercise equipment.

Task Progress & Bibliography Information FY2014 
Task Progress: The comparison groups consisting of 70 day bed rest subjects who perform no exercise (n=8) and perform traditional exercise matched to that performed on the International Space Station (n=8) are completed. The group funded by this proposal consists of n=8 subjects who will perform the same exercise prescription using small compact exercise equipment consisting of rowing and resistance exercise is about half way complete. The final data collection is expected in December 2014.

Bibliography Type: Description: (Last Updated: 05/28/2021)  Show Cumulative Bibliography Listing
 
 None in FY 2014
Project Title:  Integrated Resistance and Aerobic Exercise Training with Small Compact Exercise Equipment Reduce
Fiscal Year: FY 2013 
Division: Human Research 
Research Discipline/Element:
HRP HHC:Human Health Countermeasures
Start Date: 09/01/2012  
End Date: 08/31/2015  
Task Last Updated: 09/17/2013 
Download report in PDF pdf
Principal Investigator/Affiliation:   Ploutz-Snyder, Lori L. Ph.D. / University of Michigan 
Address:  OBL 4170, 1402 Washington Hts. 
School of Kinesiology 
Ann Arbor , MI 48109-2013 
Email: lorips@umich.edu 
Phone: (734) 764-5210  
Congressional District: 12 
Web:  
Organization Type: UNIVERSITY 
Organization Name: University of Michigan 
Joint Agency:  
Comments: Previously at Universities Space Research Association/NASA Johnson Space Center until July 2016.  
Co-Investigator(s)
Affiliation: 
Haddad, Fadia  University of California, Irvine 
Caiozzo, Vincent  University of California, Irvine 
Adams, Gregory  University of California, Irvine 
Ryder, Jeffrey  Universities Space Research Association 
Scott, Jessica  Universities Space Research Association 
Project Information: Grant/Contract No. NCC 9-58-MA02801 
Responsible Center: NSBRI 
Grant Monitor:  
Center Contact:   
Solicitation / Funding Source: 2011 Crew Health NNJ11ZSA002NA 
Grant/Contract No.: NCC 9-58-MA02801 
Project Type: GROUND 
Flight Program:  
TechPort: No 
No. of Post Docs:
No. of PhD Candidates:
No. of Master's Candidates:
No. of Bachelor's Candidates:
No. of PhD Degrees:
No. of Master's Degrees:
No. of Bachelor's Degrees:
Human Research Program Elements: (1) HHC:Human Health Countermeasures
Human Research Program Risks: (1) Aerobic:Risk of Reduced Physical Performance Capabilities Due to Reduced Aerobic Capacity
(2) Muscle:Risk of Impaired Performance Due to Reduced Muscle Mass, Strength and Endurance
(3) Osteo:Risk Of Early Onset Osteoporosis Due To Spaceflight (No longer used, July 2020)
Human Research Program Gaps: (1) A09:Identify and validate exploration countermeasure hardware for the maintenance of VO2 standards (IRP Rev G)
(2) M07:Develop the most efficient exercise program for maintenance of muscle fitness (IRP Rev F)
(3) M09:Identify and validate exploration hardware for maintenance of muscle fitness (IRP Rev F)
(4) Osteo05:We need an inflight capability to monitor bone turnover and bone mass changes during spaceflight (IRP Rev E)
(5) Osteo07:We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight (IRP Rev E)
Task Description: This proposal aims to validate in an analog setting a small compact exercise device for the protection of cardiovascular, muscle, and bone health. This study leverages both currently funded NSBRI and NASA work to bring together for the first time, a promising new exercise device and exercise prescription thus placing this study at a high countermeasure readiness level (moving from 6-7). More specifically, the NSBRI funded M-MED device uses a flywheel to provide loading for either high force-low repetition resistance exercise or low force-high repetition, endurance exercise (rowing). Recent data support M-MED training effectiveness in both ambulatory subjects and over 10 days of muscle unloading using unilateral lower limb suspension model. Accordingly, a new NASA funded exercise prescription study integrating resistance and aerobic training (iRAT) has been effective in the preservation of muscle and cardiovascular function over 14 days of bedrest, but requires the use of 5 different exercise machines. This proposal will combine the M-MED exercise device and the iRAT exercise prescription into a 70 day bedrest study. Outcome measurements related to cardiovascular, muscle and bone health will be obtained and integrated to assess countermeasure effectiveness.

Research Impact/Earth Benefits: The comparison of a single exercise device to an ISS-like suite of exercise equipment will inform long duration exploration exercise hardware requirements.

Task Progress & Bibliography Information FY2013 
Task Progress: Data collection for the control and the traditional exercise subjects (70 days of bed rest) is ongoing. In the fall we expect to enroll the first MMED bed rest subject.

Bibliography Type: Description: (Last Updated: 05/28/2021)  Show Cumulative Bibliography Listing
 
 None in FY 2013
Project Title:  Integrated Resistance and Aerobic Exercise Training with Small Compact Exercise Equipment Reduce
Fiscal Year: FY 2012 
Division: Human Research 
Research Discipline/Element:
HRP HHC:Human Health Countermeasures
Start Date: 09/01/2012  
End Date: 08/31/2015  
Task Last Updated: 10/23/2012 
Download report in PDF pdf
Principal Investigator/Affiliation:   Ploutz-Snyder, Lori L. Ph.D. / University of Michigan 
Address:  OBL 4170, 1402 Washington Hts. 
School of Kinesiology 
Ann Arbor , MI 48109-2013 
Email: lorips@umich.edu 
Phone: (734) 764-5210  
Congressional District: 12 
Web:  
Organization Type: UNIVERSITY 
Organization Name: University of Michigan 
Joint Agency:  
Comments: Previously at Universities Space Research Association/NASA Johnson Space Center until July 2016.  
Co-Investigator(s)
Affiliation: 
Caiozzo, Vincent  University of California, Irvine 
Haddad, Fadia  University of California, Irvine 
Ryder, Jeffrey  Universities Space Research Association 
Scott, Jessica  Universities Space Research Association 
Project Information: Grant/Contract No. NCC 9-58-MA02801 
Responsible Center: NSBRI 
Grant Monitor:  
Center Contact:   
Solicitation / Funding Source: 2011 Crew Health NNJ11ZSA002NA 
Grant/Contract No.: NCC 9-58-MA02801 
Project Type: GROUND 
Flight Program:  
TechPort: No 
No. of Post Docs:  
No. of PhD Candidates:  
No. of Master's Candidates:  
No. of Bachelor's Candidates:  
No. of PhD Degrees:  
No. of Master's Degrees:  
No. of Bachelor's Degrees:  
Human Research Program Elements: (1) HHC:Human Health Countermeasures
Human Research Program Risks: (1) Aerobic:Risk of Reduced Physical Performance Capabilities Due to Reduced Aerobic Capacity
(2) Muscle:Risk of Impaired Performance Due to Reduced Muscle Mass, Strength and Endurance
(3) Osteo:Risk Of Early Onset Osteoporosis Due To Spaceflight (No longer used, July 2020)
Human Research Program Gaps: (1) A09:Identify and validate exploration countermeasure hardware for the maintenance of VO2 standards (IRP Rev G)
(2) M07:Develop the most efficient exercise program for maintenance of muscle fitness (IRP Rev F)
(3) M09:Identify and validate exploration hardware for maintenance of muscle fitness (IRP Rev F)
(4) Osteo05:We need an inflight capability to monitor bone turnover and bone mass changes during spaceflight (IRP Rev E)
(5) Osteo07:We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight (IRP Rev E)
Task Description: This proposal aims to validate in an analog setting a small compact exercise device for the protection of cardiovascular, muscle, and bone health. This study leverages both currently funded NSBRI and NASA work to bring together for the first time, a promising new exercise device and exercise prescription thus placing this study at a high countermeasure readiness level (moving from 6-7). More specifically, the NSBRI funded M-MED device uses a flywheel to provide loading for either high force-low repetition resistance exercise or low force-high repetition, endurance exercise (rowing). Recent data support M-MED training effectiveness in both ambulatory subjects and over 10 days of muscle unloading using unilateral lower limb suspension model. Accordingly, a new NASA funded exercise prescription study integrating resistance and aerobic training (iRAT) has been effective in the preservation of muscle and cardiovascular function over 14 days of bedrest, but requires the use of 5 different exercise machines. This proposal will combine the M-MED exercise device and the iRAT exercise prescription into a 70 day bedrest study. Outcome measurements related to cardiovascular, muscle and bone health will be obtained and integrated to assess countermeasure effectiveness.

Research Impact/Earth Benefits: 0

Task Progress & Bibliography Information FY2012 
Task Progress: New project for FY2012.

Bibliography Type: Description: (Last Updated: 05/28/2021)  Show Cumulative Bibliography Listing
 
 None in FY 2012