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Project Title:  Cell Phone-based Lateral Flow Assay for Blood Biomarker Detection Reduce
Fiscal Year: FY 2013 
Division: Human Research 
Research Discipline/Element:
HRP ExMC:Exploration Medical Capabilities
Start Date: 07/23/2013  
End Date: 07/22/2015  
Task Last Updated: 04/28/2014 
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Principal Investigator/Affiliation:   Beshay, Manal  Ph.D. / Intelligent Optical Systems, Inc. 
Address:  2520 W 237th Street 
 
Torrance , CA 90505-5217 
Email: mbeshay@intopsys.com 
Phone: 310-530-7130  
Congressional District: 43 
Web:  
Organization Type: INDUSTRY 
Organization Name: Intelligent Optical Systems, Inc. 
Joint Agency:  
Comments:  
Project Information: Grant/Contract No. NNX13CA59C 
Responsible Center: NASA JSC 
Grant Monitor: Watkins, Sharmi1a  
Center Contact: 281.483.0395 
sharmila.watkins@nasa.gov 
Solicitation / Funding Source: SBIR Phase II 
Grant/Contract No.: NNX13CA59C 
Project Type: GROUND 
Flight Program:  
TechPort: No 
No. of Post Docs:  
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Human Research Program Elements: (1) ExMC:Exploration Medical Capabilities
Human Research Program Risks: (1) ExMC:Risk of Unacceptable Health and Mission Outcomes Due to Limitations of In-flight Medical Capabilities (IRP Rev E)
Human Research Program Gaps: (1) ExMC 4.05:We do not have the capability to measure laboratory analytes in a minimally invasive manner during exploration missions (IRP Rev E)
Task Description: The ability to integrate a sensor platform with a cell phone for health monitoring and disease diagnosis for astronauts in space has the potential to be cost effective and space saving. In this proposal, Intelligent Optical Systems (IOS) builds upon its expertise in lateral flow test strip (LFTS) assays by integrating an LFTS with a cell phone for the quantitative measurement of blood-based biomarkers. Our innovative and extremely cost-effective multi-analyte LFTS approach is eminently suited for space travel. Taking advantage of the built-in flash and high resolution camera, in Phase I we have modified a commercially available cell phone with optical filters, lenses, a UV LED excitation source, and a cassette holder for LFTS image capture. In Phase II, we will expand the capability of cell phone-based LFTS for an antibody-antigen sandwich binding assay to include blood gas measurements by developing sensitive indicator films to be integrated with our cell phone-based detector. Furthermore, we will develop cell phone-based software for on-cell phone detection and data processing with an expanded panel of biomarkers, advancing the TRL from 5 to 7.

POTENTIAL NASA COMMERCIAL APPLICATIONS: Future space missions will require prolonged stays of crew members onboard space stations, and on other spacecraft for journeys to other planets. Increasingly complex space missions will also require monitoring the health status of astronauts, preferably in a point-of-care apparatus that is compact and simple. The IOS system will enable NASA to monitor the health status of crew members by means of simple blood-based biomarker detection. A lateral flow test strip will be integrated with a cell phone into a simple and compact blood biomarker detection platform. This platform will gather diagnostic information in the absence of medically trained personnel, and can also monitor the health of aircraft pilots, cabin crews, passengers, and others in aeronautics-related occupations.

Research Impact/Earth Benefits: A cell phone-based serum biomarker detection platform will be cost-effective and compact not only for space exploration; it will also benefit the overall healthcare industry. Cell phones are becoming increasingly prevalent all over the world, with approximately five billion subscribers worldwide, and in the U.S. approximately one in three adults owns a smart phone. The ability to integrate a simple LFTS assay with a cell phone will enable healthcare providers to perform blood tests for many diseases on a wide population, including populations in remote areas where healthcare facilities are sparse. Such a platform can have a major impact in developing countries where a simple cell phone can be converted into a blood marker detection platform, avoiding the cost of acquiring dedicated medical equipment; furthermore, this point-of-care device improves the probability of early detection, yielding additional savings in overall healthcare cost. Military field medicine will also benefit from the availability of a versatile handheld medical blood testing device that takes advantage of the ubiquitous mobile phone to minimize weight and power requirements.

Task Progress & Bibliography Information FY2013 
Task Progress: New project for FY2013. Reporting not required for this SBIR Phase 2 project.

Bibliography Type: Description: (Last Updated: ) 

Show Cumulative Bibliography Listing
 
 None in FY 2013