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Project Title:  Evaluation of Commercial Compression Garments as a Countermeasure to Post-Spaceflight Orthostatic Intolerance (OIG DSO641) Reduce
Fiscal Year: FY 2012 
Division: Human Research 
Research Discipline/Element:
HRP HHC:Human Health Countermeasures
Start Date: 02/17/2010  
End Date: 04/30/2012  
Task Last Updated: 09/12/2013 
Download report in PDF pdf
Principal Investigator/Affiliation:   Platts, Steven H. Ph.D. / NASA Johnson Space Center 
Address:  Cardiovascular Laboratory 
Biomedical Research and Environmental Sciences Division 
Houston , TX 77058 
Email: steven.platts-1@nasa.gov 
Phone: 281-483-8177  
Congressional District: 36 
Web:  
Organization Type: NASA CENTER 
Organization Name: NASA Johnson Space Center 
Joint Agency:  
Comments:  
Co-Investigator(s)
Affiliation: 
Locke, James  Ph.D. NASA Johnson Space Center 
Stenger, Michael  Ph.D. Wyle Laboratories, Inc./NASA Johnson Space Center 
Lee, Stuart  M.S. Wyle Laboratories, Inc./NASA Johnson Space Center 
Westby, Christian  Ph.D. Universities Space Research Association 
Project Information: Grant/Contract No. Directed Research 
Responsible Center: NASA JSC 
Grant Monitor: Villarreal, Jennifer  
Center Contact: 281-483-7306 
jennifer.v311larreal@nasa.gov 
Solicitation / Funding Source: Directed Research 
Grant/Contract No.: Directed Research 
Project Type: FLIGHT 
Flight Program: Shuttle 
TechPort: Yes 
No. of Post Docs:  
No. of PhD Candidates:  
No. of Master's Candidates:  
No. of Bachelor's Candidates:  
No. of PhD Degrees:  
No. of Master's Degrees:  
No. of Bachelor's Degrees:  
Human Research Program Elements: (1) HHC:Human Health Countermeasures
Human Research Program Risks: (1) OI:Risk of Orthostatic Intolerance during Re-Exposure to Gravity
Human Research Program Gaps: (1) CV03:Is orthostatic intolerance a potential hazard?
Task Description: One of the most important physiological changes that may negatively impact crew safety is post-flight orthostatic intolerance. Astronauts who have orthostatic intolerance are unable to maintain a normal systolic blood pressure during head-up tilt, have elevated heart rates, and may experience presyncope or syncope with upright posture. This problem affects about 20-30% of astronauts who fly short-duration missions (4–18 days) and 60-80% of astronauts who fly long-duration missions. This condition creates a potential hazard for crew members during re-entry and after landing, especially for emergency egress contingencies.

Two countermeasures are currently employed to ameliorate post-flight orthostatic intolerance: fluid loading and an anti-gravity suit. Unfortunately, neither of these is completely effective for all phases of landing and egress; thus, continued countermeasure development is important. Preliminary evidence has shown that commercial graded compression garments that include abdominal compression can significantly improve orthostatic tolerance.

The specific aims of this study were:

1. Evaluate custom-fitted, commercial compression garments as countermeasures to post-flight orthostatic intolerance during stand tests performed before and after spaceflight.

2. Determine if these garments, which provide a continuous, graded compression from the foot to the hip, with a static compression over the lower abdomen, provide superior fit and comfort as well as being easier to don.

Research Impact/Earth Benefits:

Task Progress & Bibliography Information FY2012 
Task Progress: Results from this study indicate that the gradient compression garments prevented the tachycardia and stroke volume reduction normally associated with a 3.5 min stand test after spaceflight. The garments show promise as a countermeasure against post-spaceflight orthostatic intolerance, can be easily donned, and are relatively comfortable to wear. The efficacy of the garments should be validated after and during recovery from long-duration spaceflight.

[Ed. note 9/12/13: information from PI's Task Book Initial Entry Form, provided September 2013]

Bibliography Type: Description: (Last Updated: 03/01/2018)  Show Cumulative Bibliography Listing
 
Articles in Peer-reviewed Journals Stenger MB, Lee SM, Westby CM, Ribeiro LC, Phillips TR, Martin DS, Platts SH. "Abdomen-high elastic gradient compression garments during post-spaceflight stand tests." Aviat Space Environ Med. 2013 May;84(5):459-66. PMID: 23713210 , May-2013
Project Title:  Evaluation of Commercial Compression Garments as a Countermeasure to Post-Spaceflight Orthostatic Intolerance (OIG DSO641) Reduce
Fiscal Year: FY 2010 
Division: Human Research 
Research Discipline/Element:
HRP HHC:Human Health Countermeasures
Start Date: 02/17/2010  
End Date: 04/30/2012  
Task Last Updated: 09/12/2013 
Download report in PDF pdf
Principal Investigator/Affiliation:   Platts, Steven H. Ph.D. / NASA Johnson Space Center 
Address:  Cardiovascular Laboratory 
Biomedical Research and Environmental Sciences Division 
Houston , TX 77058 
Email: steven.platts-1@nasa.gov 
Phone: 281-483-8177  
Congressional District: 36 
Web:  
Organization Type: NASA CENTER 
Organization Name: NASA Johnson Space Center 
Joint Agency:  
Comments:  
Co-Investigator(s)
Affiliation: 
Locke, James  Ph.D. NASA Johnson Space Center 
Stenger, Michael  Ph.D. Wyle Laboratories, Inc./NASA Johnson Space Center 
Lee, Stuart  M.S. Wyle Laboratories, Inc./NASA Johnson Space Center 
Westby, Christian  Ph.D. Universities Space Research Association 
Project Information: Grant/Contract No. Directed Research 
Responsible Center: NASA JSC 
Grant Monitor: Villarreal, Jennifer  
Center Contact: 281-483-7306 
jennifer.v311larreal@nasa.gov 
Solicitation / Funding Source: Directed Research 
Grant/Contract No.: Directed Research 
Project Type: FLIGHT 
Flight Program: Shuttle 
TechPort: Yes 
No. of Post Docs:  
No. of PhD Candidates:  
No. of Master's Candidates:  
No. of Bachelor's Candidates:  
No. of PhD Degrees:  
No. of Master's Degrees:  
No. of Bachelor's Degrees:  
Human Research Program Elements: (1) HHC:Human Health Countermeasures
Human Research Program Risks: (1) OI:Risk of Orthostatic Intolerance during Re-Exposure to Gravity
Human Research Program Gaps: (1) CV03:Is orthostatic intolerance a potential hazard?
Task Description: One of the most important physiological changes that may negatively impact crew safety is post-flight orthostatic intolerance. Astronauts who have orthostatic intolerance are unable to maintain a normal systolic blood pressure during head-up tilt, have elevated heart rates, and may experience presyncope or syncope with upright posture. This problem affects about 20-30% of astronauts who fly short-duration missions (4–18 days) and 60-80% of astronauts who fly long-duration missions. This condition creates a potential hazard for crew members during re-entry and after landing, especially for emergency egress contingencies.

Two countermeasures are currently employed to ameliorate post-flight orthostatic intolerance: fluid loading and an anti-gravity suit. Unfortunately, neither of these is completely effective for all phases of landing and egress; thus, continued countermeasure development is important. Preliminary evidence has shown that commercial graded compression garments that include abdominal compression can significantly improve orthostatic tolerance.

The specific aims of this study were:

1. Evaluate custom-fitted, commercial compression garments as countermeasures to post-flight orthostatic intolerance during stand tests performed before and after spaceflight.

2. Determine if these garments, which provide a continuous, graded compression from the foot to the hip, with a static compression over the lower abdomen, provide superior fit and comfort as well as being easier to don.

Research Impact/Earth Benefits: 0

Task Progress & Bibliography Information FY2010 
Task Progress: New project for FY2010.

[Ed. note 9/12/2013: added to Task Book when received information from HRP]

Bibliography Type: Description: (Last Updated: 03/01/2018)  Show Cumulative Bibliography Listing
 
 None in FY 2010