Task Progress:
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This section on task progress deals with the technical aspects of the program. The reader is referred to the Main findings section for Scientific Progress (See Task Description section above).
Flight Scheduling Progress
Leading up to year 4 of this project, the project had been hamstrung by the problems directly stemming from changes in the NASA policy for accessing the reduced gravity aircraft. In brief, we attempted to fly multiple times with NASA without success. We instituted an attempt to fly the experiment on the European A300, securing European Space Agency (ESA) approval for those flights. After considerable effort this was abandoned in Feb 2011. At the time of the last progress report (April 2011) we articulated our contingency plans for ensuring scientific return from this project in the face of flight difficulties. Our preferred approach (Plan A) was a week of flights in July 2011 and a second week (date TBD). Our second approach (Plan B) was to buy the plane for a single week of flights. This approach had the advantage of flight certainty, but the significant disadvantage of reducing us to a single flight week (based on cost). When the July 2011 flight opportunity offered as part of the FAST program disappeared we opted for Plan B. In order to accomplish this we joined forces with a NASA investigator (Dr. Mark Shelhammer, Johns Hopkins) who was facing similar difficulties in terms of scheduling flights. Between us, we were able to commit a sufficient amount of flight money to guarantee a 3-day flight week (our absolute minimum requirement). Once we committed to this, other customers wanting fewer flight resources came on board because there was certainty the flights would occur. The effect of this was to increase the money pool to a level sufficient to allow a 4-flight week. In the week of August 29 to September 2, 2011 we finally succeeded in flying the experiment using the 4-micron particle size droplets. We subsequently learned of a further pathway to flight via the NASA Flight Opportunities (FO) program. We positioned ourselves for this opportunity, but when the FO program solicitation was released in April 2012, parabolic flight support was (to our great surprise, given previous discussions) explicitly excluded, making this pathway unavailable to us. We have on several occasions explored further routine flight opportunities through NASA Life Sciences (the standard path) with nothing forthcoming. In summary, we have succeeded in completing a 4-flight week of activities in August-Sept 2011. Further attempts to fly have been unsuccessful.
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Bibliography Type:
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Description: (Last Updated: 03/11/2021)
Show Cumulative Bibliography Listing
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Abstracts for Journals and Proceedings
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Darquenne C, Zeman KL, Sa RC, Cooper TK, Fine JM, Bennett WD, Prisk GK. "Removal of sedimentation decreases deposition of coarse particles in the lung periphery, reducing retention." 2013 NASA Human Research Program Investigators’ Workshop, Galveston, TX, February 12-14, 2013. 2013 NASA Human Research Program Investigators’ Workshop, Galveston, TX, February 12-14, 2013. , Feb-2013
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Articles in Peer-reviewed Journals
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Darquenne C. "Aerosol deposition in the human lung in reduced gravity." J Aerosol Med Pulm Drug Deliv. 2014 Jun;27(3):170-7. Review. http://dx.doi.org/10.1089/jamp.2013.1079 ; PubMed PMID: 24870702; PubMed Central PMCID: PMC4088354 , Jun-2014
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Articles in Peer-reviewed Journals
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Lejeune L, Caiani EG, Prisk GK, Migeotte PF. "Evaluation of ensemble averaging methods in 3D ballistocardiography.
" Conf Proc IEEE Eng Med Biol Soc. 2014 Aug;2014:5176-9. https://doi.org/10.1109/EMBC.2014.6944791 ; PubMed PMID: 25571159 , Aug-2014
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Articles in Peer-reviewed Journals
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Prisk GK. "Microgravity and the respiratory system." Eur Respir J. 2014 May;43(5):1459-71. Epub 2014 Mar 6. Review. https://doi.org/10.1183/09031936.00001414 ; PubMed PMID: 24603820 , May-2014
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Articles in Peer-reviewed Journals
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Migeotte PF, Lejeune L, Delière Q, Caiani E, Casellato C, Tank J, Funtova I, Baevsky R, Prisk GK, van de Borne P. "Three dimensional Ballistocardiogram and Seismocardiogram: what do they have in common?" Conf Proc IEEE Eng Med Biol Soc. 2014;2014:6085-8. https://doi.org/10.1109/EMBC.2014.6945017 ; PMID: 25571385 , Aug-2014
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Articles in Peer-reviewed Journals
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Lejeune L, Prisk GK, Nonclercq A, Migeotte PF. "MRI-based aortic blood flow model in 3D ballistocardiography." Conf Proc IEEE Eng Med Biol Soc. 2015 Aug;2015:7171-4. https://doi.org/10.1109/EMBC.2015.7320046 ; PMID: 26737946
, Aug-2015
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Articles in Peer-reviewed Journals
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Sá RC, Zeman KL, Bennett WD, Prisk GK, Darquenne C. "Effect of posture on regional deposition of coarse particles in the healthy human lung." J Aerosol Med Pulm Drug Deliv. 2015 Dec;28(6):423-31. Epub 2015 Mar 31. https://doi.org/10.1089/jamp.2014.1189 ; PMID: 25826480 , Dec-2015
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Articles in Peer-reviewed Journals
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Sá RC, Zeman KL, Bennett WD, Prisk GK, Darquenne C. "Regional ventilation is the main determinant of alveolar deposition of coarse particles in the supine healthy human lung during tidal breathing." J Aerosol Med Pulm Drug Deliv. 2017 Oct;30(5):322-31. Epub 2017 Mar 9. https://doi.org/10.1089/jamp.2016.1336 ; PMID: 28277885; PMCID: PMC5650708 , Oct-2017
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Articles in Peer-reviewed Journals
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Asadi AK, Sá RC, Arai TJ, Theilmann RJ, Hopkins SR, Buxton RB, Prisk GK. "Regional pulmonary perfusion patterns in humans are not significantly altered by inspiratory hypercapnia." J Appl Physiol (1985). 2019 Aug 1;127(2):365-75. https://doi.org/10.1152/japplphysiol.00254.2018 ; PMID: 31169470; PMCID: PMC6732437 , Aug-2019
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Articles in Peer-reviewed Journals
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Prisk GK. "Pulmonary challenges of prolonged journeys to space: taking your lungs to the moon." Med J Aust. 2019 Sep;211(6):271-6. https://doi.org/10.5694/mja2.50312 ; PMID: 31420881; PMCID: PMC6745695 , Sep-2019
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Articles in Peer-reviewed Journals
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Inan OT, Migeotte PF, Park KS, Etemadi M, Tavakolian K, Casanella R, Zanetti J, Tank J, Funtova I, Prisk GK, Di Rienzo M. "Ballistocardiography and seismocardiography: a review of recent advances." IEEE J Biomed Health Inform. 2015 Jul;19(4):1414-27. Epub 2014 Oct 7. https://doi.org/10.1109/JBHI.2014.2361732 ; PMID: 25312966 , Jul-2015
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Articles in Peer-reviewed Journals
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Darquenne C, Prisk GK. "Particulate deposition in the human lung under lunar habitat conditions." Aviat Space Environ Med. 2013 Mar;84(3):190-5. PubMed PMID: 23513279 , Mar-2013
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Articles in Peer-reviewed Journals
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Prisk GK, Sa RC, Darquenne C. "Cardiogenic mixing increases aerosol deposition in the human lung in the absence of gravity." Acta Astronautica. In Press, Corrected Proof. Available online 12 June 2012. http://dx.doi.org/10.1016/j.actaastro.2012.05.022
, Jun-2012
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Articles in Peer-reviewed Journals
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Henderson AC, Sa RC, Barash IA, Holverda S, Buxton RB, Hopkins SR, Prisk GK. "Rapid intravenous infusion of 20 mL/kg saline alters the distribution of perfusion in healthy supine humans." Respir Physiol Neurobiol. 2012 Mar 15;180(2-3):331-41. Epub 2011 Dec 31. http://dx.doi.org/10.1016/j.resp.2011.12.013 ; PubMed PMID: 22227320 , Mar-2012
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Articles in Peer-reviewed Journals
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Linnarsson D, Carpenter J, Fubini B, Gerde P, Karlsson LL, Loftus DJ, Prisk GK, Staufer U, Tranfield EM, van Westrenen W. "Toxicity of lunar dust." Planetary and Space Science. 2012 Dec;74(1):57-71.
http://dx.doi.org/10.1016/j.pss.2012.05.023
, Jul-2012
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Articles in Peer-reviewed Journals
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Migeotte PF, De Ridder S, Tank J, Pattyn N, Funtova I, Baevsky R, Neyt X, Prisk GK. "Three dimensional ballisto- and seismo-cardiography: HIJ wave amplitudes are poorly correlated to maximal systolic force vector." Conf Proc IEEE Eng Med Biol Soc. 2012;2012:5046-9. http://dx.doi.org/10.1109/EMBC.2012.6347127 ; PubMed PMID: 23367062 (EMBC 2012. 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, San Diego, CA, Aug. 28-Sept. 1 2012.) , Oct-2012
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Articles in Peer-reviewed Journals
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Migeotte PF, Tank J, Pattyn N, Funtova I, Baevsky R, Neyt X, Prisk GK. "Three dimensional ballistocardiography: methodology and results from microgravity and dry immersion." Conf Proc IEEE Eng Med Biol Soc. 2011;2011:4271-4. http://dx.doi.org/10.1109/IEMBS.2011.6091060 ; PubMed PMID: 22255283 (EMBC 2011. 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Boston, MA, Aug. 30 2011-Sept. 3 2011.) , Aug-2011
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Articles in Peer-reviewed Journals
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De Ridder S, Migeotte PF, Neyt X, Pattyn N, Prisk GK. "Three-dimensional ballistocardiography in microgravity: a review of past research." Conf Proc IEEE Eng Med Biol Soc. 2011;2011:4267-70. http://dx.doi.org/10.1109/IEMBS.2011.6091059 ; PubMed PMID: 22255282 (EMBC 2011. 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Boston, MA, Aug. 30-Sept. 3 2011.)
, Aug-2011
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Articles in Peer-reviewed Journals
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Asadi AK, Cronin MV, Sá RC, Theilmann RJ, Holverda S, Hopkins SR, Buxton RB, Prisk GK. "Spatial-temporal dynamics of pulmonary blood flow in the healthy human lung in response to altered FI(O2)." J Appl Physiol. 2013 Jan 1;114(1):107-18. Epub 2012 Oct 25.
http://dx.doi.org/10.1152/japplphysiol.00433.2012 ; PubMed PMID: 23104691 , Jan-2013
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Awards
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Prisk GK. "ARTP Lifetime achievement award for services to respiratory science, January 2012." Jan-2012
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