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Task Book: Biological & Physical Sciences Division and Human Research Program
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Project Title:  Efficacy of Jobst Compression Garments to Prevent Orthostatic Intolerance for up to Three Days following 14 Days of Bed Rest Reduce
Fiscal Year: FY 2013 
Division: Human Research 
Research Discipline/Element:
HRP HHC:Human Health Countermeasures
Start Date: 10/01/2010  
End Date: 10/31/2012  
Task Last Updated: 08/14/2013 
Download report in PDF pdf
Principal Investigator/Affiliation:   Stenger, Michael  Ph.D. / NASA Johnson Space Center 
Address:  SK3/Biomedical Research and Environmental Sciences Division 
 
Houston , TX 77058 
Email: michael.b.stenger@nasa.gov 
Phone: 281-483-1311  
Congressional District: 22 
Web:  
Organization Type: NASA CENTER 
Organization Name: NASA Johnson Space Center 
Joint Agency:  
Comments: NOTE Aug 2018: Previously with KBRwyle at Johnson Space Center  
Project Information: Grant/Contract No. Directed Research 
Responsible Center: NASA JSC 
Grant Monitor: Norsk, Peter  
Center Contact:  
Peter.norsk@nasa.gov 
Solicitation / Funding Source: Directed Research 
Grant/Contract No.: Directed Research 
Project Type: GROUND 
Flight Program:  
TechPort: Yes 
No. of Post Docs:
No. of PhD Candidates:
No. of Master's Candidates:
No. of Bachelor's Candidates:
No. of PhD Degrees:
No. of Master's Degrees:
No. of Bachelor's Degrees:
Human Research Program Elements: (1) HHC:Human Health Countermeasures
Human Research Program Risks: (1) OI:Risk of Orthostatic Intolerance during Re-Exposure to Gravity
Human Research Program Gaps: (1) CV03:Is orthostatic intolerance a potential hazard?
Task Description: Aims:

1. To determine whether subjects wearing breast-high, graded compression garments become orthostatically intolerant after 14 days of head-down tilt bed rest (Groups 1 and 2). Measures of efficacy will be presyncope-free survival to 80° head-up tilt testing and responses in blood pressure, heart rate, stroke volume, and cardiac output.

2. To determine the time course of cardiovascular readaptation during the first three days of post-bed rest (BR) recovery after using compression garments for a short period of time on BR+0 (Group 1). The brief usage of high compression garments on BR+0 models the use of the anti-G suit (AGS) among Space Shuttle crewmembers. Readaptation will be measured by responses of blood pressure, heart rate, stroke volume, cardiac output, and presyncope-free survival time to 15-minute head-up tilt tests on BR+1 and BR+3 as well as measures of plasma volume each day of recovery.

3. To determine the effect of wearing graded compression garments on the time course of cardiovascular readaptation during the first three days of post-bed rest recovery (Group 2). Readaptation will be measured by responses of blood pressure, heart rate, stroke volume, cardiac output, and presyncope-free survival time to 15-minute head-up tilt tests on BR+1 and BR+3 as well as measures of plasma volume each day of recovery.

Rationale for HRP Directed Research: This research is directed because it contains highly constrained research, which requires focused and constrained data gathering and analysis that is more appropriately obtained through a non-competitive proposal.

Research Impact/Earth Benefits: Findings from this study have the potential to impact treatment of patients who are hypotensive and/or suffer from episodes of orthostatic intolerance. Commercially-available knee-high and thigh-high compression garments, while easy to don and convenient to wear, have limited effectiveness as previously tested in our laboratory. The commercially-available breast-high garment, while an effective protection against orthostatic intolerance, can be difficult to don, uncomfortable, and/or inconvenient to remove to urinate or defecate. In contrast, the three-piece garment developed for this project provides the same amount of coverage as the commercially-available breast-high garment but provides greater levels of compression than the commercially-available breast-high garment, is an effective countermeasure to orthostatic intolerance, is easy to don and doff, and can be more easily adjusted for comfort. The improvements to the wear and comfort realized in the development of the three-piece garments should enhance compliance with long-term wearing of compression garments, reduce hypotensive episodes, and improve the lifestyle of patients with orthostatic intolerance. A cardiologist who treats these types of patients has complimented the investigator team on the design of the test garment, and the manufacturer of the modified garment has applied for a US patent.

Task Progress & Bibliography Information FY2013 
Task Progress: This project was completed with a total of 16 volunteers, 8 control subjects (Group 1), and 8 treatment subjects (Group 2). Data analysis was completed, and a manuscript has been submitted for consideration of publication in a peer-reviewed scientific journal.

Results from this work indicate that wearing the abdomen-high compression garments during an 80-degree head-up tilt test (Groups 1 and 2) prevented the orthostatic intolerance that is normally present after BR. Thigh-high garments (Group 2) provided some protection after BR, and wearing these garments did not impair recovery as measured by a tilt test three days after bed rest.

(Ed. note: updated report provided by PI August 2013.)

Bibliography Type: Description: (Last Updated: 08/30/2021)  Show Cumulative Bibliography Listing
 
Abstracts for Journals and Proceedings Stenger MB, Lee SMC, Ribeiro LC, Brown AK, Westby CM, Platts SH. "Alternative compression garments." 2012 NASA Human Research Program Investigators’ Workshop, Houston, TX, February 14-16, 2012.

2012 NASA Human Research Program Investigators’ Workshop, Houston, TX, February 14-16, 2012. , Feb-2012

Articles in Peer-reviewed Journals Stenger MB, Lee SM, Ribeiro LC, Phillips TR, Ploutz-Snyder RJ, Willig MC, Westby CM, Platts SH. "Gradient compression garments protect against orthostatic intolerance during recovery from bed rest." European Journal of Applied Physiology. 2014 Mar;114(3):597-608. Epub 2013 Dec 14. http://dx.doi.org/10.1007/s00421-013-2787-4 ; PubMed PMID: 24337701 (originally reported as Submitted July 2013.) , Mar-2014
Project Title:  Efficacy of Jobst Compression Garments to Prevent Orthostatic Intolerance for up to Three Days following 14 Days of Bed Rest Reduce
Fiscal Year: FY 2011 
Division: Human Research 
Research Discipline/Element:
HRP HHC:Human Health Countermeasures
Start Date: 10/01/2010  
End Date: 10/31/2012  
Task Last Updated: 09/14/2012 
Download report in PDF pdf
Principal Investigator/Affiliation:   Stenger, Michael  Ph.D. / NASA Johnson Space Center 
Address:  SK3/Biomedical Research and Environmental Sciences Division 
 
Houston , TX 77058 
Email: michael.b.stenger@nasa.gov 
Phone: 281-483-1311  
Congressional District: 22 
Web:  
Organization Type: NASA CENTER 
Organization Name: NASA Johnson Space Center 
Joint Agency:  
Comments: NOTE Aug 2018: Previously with KBRwyle at Johnson Space Center  
Project Information: Grant/Contract No. Directed Research 
Responsible Center: NASA JSC 
Grant Monitor: Norsk, Peter  
Center Contact:  
Peter.norsk@nasa.gov 
Solicitation / Funding Source: Directed Research 
Grant/Contract No.: Directed Research 
Project Type: GROUND 
Flight Program:  
TechPort: Yes 
No. of Post Docs:  
No. of PhD Candidates:  
No. of Master's Candidates:  
No. of Bachelor's Candidates:  
No. of PhD Degrees:  
No. of Master's Degrees:  
No. of Bachelor's Degrees:  
Human Research Program Elements: (1) HHC:Human Health Countermeasures
Human Research Program Risks: (1) OI:Risk of Orthostatic Intolerance during Re-Exposure to Gravity
Human Research Program Gaps: (1) CV03:Is orthostatic intolerance a potential hazard?
Task Description: Aims:

1. To determine whether subjects wearing breast-high, graded compression garments become orthostatically intolerant after 14 days of head-down tilt bed rest (Groups 1 and 2). Measures of efficacy will be presyncope-free survival to 80° head-up tilt testing and responses in blood pressure, heart rate, stroke volume, and cardiac output.

2. To determine the time course of cardiovascular readaptation during the first three days of post-bed rest recovery after using compression garments for a short period of time on BR+0 (Group 1). The brief usage of high compression garments on BR+0 models the use of the AGS among Space Shuttle crewmembers. Readaptation will be measured by responses of blood pressure, heart rate, stroke volume, cardiac output and presyncope-free survival time to 15-minute head-up tilt tests on BR+1 and BR+3 as well as measures of plasma volume each day of recovery.

3. To determine the effect of wearing graded compression garments on the time course of cardiovascular readaptation during the first three days of post-bed rest recovery (Group 2). Readaptation will be measured by responses of blood pressure, heart rate, stroke volume, cardiac output and presyncope-free survival time to 15-minute head-up tilt tests on BR+1 and BR+3 as well as measures of plasma volume each day of recovery.

Rationale for HRP Directed Research: This research is directed because it contains highly constrained research, which requires focused and constrained data gathering and analysis that is more appropriately obtained through a non-competitive proposal.

Research Impact/Earth Benefits: 0

Task Progress & Bibliography Information FY2011 
Task Progress: New project for FY2011.

[Editor's note: added to Task Book in September 2012 when received information]

Bibliography Type: Description: (Last Updated: 08/30/2021)  Show Cumulative Bibliography Listing
 
 None in FY 2011