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Project Title:  Modulation of Muscle Function by Lower Limb Loading during Space Flight Reduce
Fiscal Year: FY 2013 
Division: Human Research 
Research Discipline/Element:
HRP HHC:Human Health Countermeasures
Start Date: 02/01/2012  
End Date: 01/31/2013  
Task Last Updated: 03/11/2013 
Download report in PDF pdf
Principal Investigator/Affiliation:   Paloski, William H Ph.D. / University of Houston 
Address:  Health & Human Performance 
3855 Holman St, Garrison 104 
Houston , TX 77204-6015 
Email: whpaloski@uh.edu 
Phone: (713) 743-9272   
Congressional District: 18 
Web:  
Organization Type: UNIVERSITY 
Organization Name: University of Houston 
Joint Agency:  
Comments: PI moved to University of Houston in September 2008, from NASA JSC.  
Co-Investigator(s)
Affiliation: 
Clarke, Mark  University of Houston 
Layne, Chuck  University of Houston 
O'Connor, Dan  University of Houston 
Thrasher, Timothy  University of Houston 
Key Personnel Changes / Previous PI: NOTE: PI change to Dr. Mitzi Laughlin in February 2013, result of PI Paloski's assignment to Human Research Program at JSC (Ed., 3/11/2013)
Project Information: Grant/Contract No. NNX12AF04G 
Responsible Center: NASA JSC 
Grant Monitor: Loerch, Linda  
Center Contact:  
linda.loerch-1@nasa.gov 
Solicitation / Funding Source: 2010 Crew Health NNJ10ZSA003N 
Grant/Contract No.: NNX12AF04G 
Project Type: FLIGHT 
Flight Program: ISS 
TechPort: No 
No. of Post Docs:  
No. of PhD Candidates:  
No. of Master's Candidates:  
No. of Bachelor's Candidates:  
No. of PhD Degrees:  
No. of Master's Degrees:  
No. of Bachelor's Degrees:  
Human Research Program Elements: (1) HHC:Human Health Countermeasures
Human Research Program Risks: (1) Muscle:Risk of Impaired Performance Due to Reduced Muscle Mass, Strength and Endurance
Human Research Program Gaps: (1) M02:Characterize in-flight and post-flight muscle performance (IRP Rev F)
(2) M24:Characterize the time course of changes in muscle protein turnover, muscle mass, and function during long duration space flight (IRP Rev F)
Flight Assignment/Project Notes: ISS

Task Description: Muscle size, structure, and coordination changes during spaceflight are likely triggered by absent or reduced loading of receptors in the soles of the feet and the muscles and joints of the lower limbs. To better understand the physiological bases of these adaptive responses, we propose to examine, in-flight, the relationships between lower limb loading and muscle activation, and control. The proposed experiments will study astronaut volunteers before flight and on multiple occasions during flight using the MARES device to provide loading to the feet and legs as well as device that can apply pressure to the soles of the feet. The effects on muscle activation and performance associated with foot pressure alone or foot pressure plus lower limb loading will be investigated. If successful this investigation will provide new insight into the role of lower extremity load receptors in modulating muscle function and new evidence regarding the potential for a passive loading countermeasure to attenuate the undesirable side effects of space flight on muscle function.

Research Impact/Earth Benefits: 0

Task Progress & Bibliography Information FY2013 
Task Progress: NOTE: Change in PI to Dr. Mitzi Laughlin in February 2013, result of PI Paloski's assignment to Human Research Program at JSC. See Laughlin for subsequent reporting (Ed., 3/11/2013)

Bibliography Type: Description: (Last Updated: 02/09/2021) 

Show Cumulative Bibliography Listing
 
 None in FY 2013
Project Title:  Modulation of Muscle Function by Lower Limb Loading during Space Flight Reduce
Fiscal Year: FY 2012 
Division: Human Research 
Research Discipline/Element:
HRP HHC:Human Health Countermeasures
Start Date: 02/01/2012  
End Date: 01/31/2013  
Task Last Updated: 03/27/2012 
Download report in PDF pdf
Principal Investigator/Affiliation:   Paloski, William H Ph.D. / University of Houston 
Address:  Health & Human Performance 
3855 Holman St, Garrison 104 
Houston , TX 77204-6015 
Email: whpaloski@uh.edu 
Phone: (713) 743-9272   
Congressional District: 18 
Web:  
Organization Type: UNIVERSITY 
Organization Name: University of Houston 
Joint Agency:  
Comments: PI moved to University of Houston in September 2008, from NASA JSC.  
Co-Investigator(s)
Affiliation: 
Clarke, Mark  University of Houston 
Layne, Chuck  University of Houston 
O'Connor, Dan  University of Houston 
Thrasher, Timothy  University of Houston 
Project Information: Grant/Contract No. NNX12AF04G 
Responsible Center: NASA JSC 
Grant Monitor: Norsk, Peter  
Center Contact:  
Peter.norsk@nasa.gov 
Solicitation / Funding Source: 2010 Crew Health NNJ10ZSA003N 
Grant/Contract No.: NNX12AF04G 
Project Type: FLIGHT 
Flight Program: ISS 
TechPort: No 
No. of Post Docs:  
No. of PhD Candidates:  
No. of Master's Candidates:  
No. of Bachelor's Candidates:  
No. of PhD Degrees:  
No. of Master's Degrees:  
No. of Bachelor's Degrees:  
Human Research Program Elements: (1) HHC:Human Health Countermeasures
Human Research Program Risks: (1) Muscle:Risk of Impaired Performance Due to Reduced Muscle Mass, Strength and Endurance
Human Research Program Gaps: (1) M02:Characterize in-flight and post-flight muscle performance (IRP Rev F)
(2) M24:Characterize the time course of changes in muscle protein turnover, muscle mass, and function during long duration space flight (IRP Rev F)
Flight Assignment/Project Notes: ISS

Task Description: Muscle size, structure, and coordination changes during spaceflight are likely triggered by absent or reduced loading of receptors in the soles of the feet and the muscles and joints of the lower limbs. To better understand the physiological bases of these adaptive responses, we propose to examine, in-flight, the relationships between lower limb loading and muscle activation, and control. The proposed experiments will study astronaut volunteers before flight and on multiple occasions during flight using the MARES device to provide loading to the feet and legs as well as device that can apply pressure to the soles of the feet. The effects on muscle activation and performance associated with foot pressure alone or foot pressure plus lower limb loading will be investigated. If successful this investigation will provide new insight into the role of lower extremity load receptors in modulating muscle function and new evidence regarding the potential for a passive loading countermeasure to attenuate the undesirable side effects of space flight on muscle function.

Research Impact/Earth Benefits: 0

Task Progress & Bibliography Information FY2012 
Task Progress: New project for FY2012.

Bibliography Type: Description: (Last Updated: 02/09/2021) 

Show Cumulative Bibliography Listing
 
 None in FY 2012