Menu

 

The NASA Task Book
Advanced Search     

Project Title:  Integrated Medical Model (IMM) Reduce
Fiscal Year: FY 2011 
Division: Human Research 
Research Discipline/Element:
HRP ExMC:Exploration Medical Capabilities
Start Date: 10/01/2005  
End Date: 01/31/2011  
Task Last Updated: 01/06/2012 
Download report in PDF pdf
Principal Investigator/Affiliation:   Butler, Douglas  M.B.A. / Wyle Integrated Science and Engineering 
Address:  1290 Hercules Drive 
 
Houston , TX 77058 
Email: dbutler@wylehou.com 
Phone: 281-212-1380  
Congressional District: 22 
Web:  
Organization Type: NASA CENTER 
Organization Name: Wyle Integrated Science and Engineering 
Joint Agency:  
Comments:  
Co-Investigator(s)
Affiliation: 
Freire de Carvalho, Mary  Ph.D. Wyle Integrated Science and Engineering 
Kerstman, Eric  M.D. University of Texas Medical Branch - Galveston 
Minard, Charles  Ph.D. Wyle Integrated Science and Engineering 
Myers, Jerry  Ph.D. NASA - Glenn Research Center 
Walton, Marlei  Ph.D. Wyle Integrated Science and Engineering 
Strauss, Sam  M.D. Wyle Integrated Science and Engineering 
Saile, Lynn  M.S. Wyle Integrated Science and Engineering 
Lopez, Vilma  M.S. Wyle Integrated Science and Engineering 
Iyengar, Madurai  Sriram Ph.D. University of Texas 
Bickham, Grandin  M.S. Wyle Integrated Science and Engineering 
Project Information: Grant/Contract No. Directed Research 
Responsible Center: NASA JSC 
Grant Monitor: Watkins, Sharmi1a  
Center Contact: 281.483.0395 
sharmila.watkins@nasa.gov 
Solicitation / Funding Source: Directed Research 
Grant/Contract No.: Directed Research 
Project Type: GROUND 
Flight Program:  
TechPort: Yes 
No. of Post Docs:  
No. of PhD Candidates:  
No. of Master's Candidates:  
No. of Bachelor's Candidates:  
No. of PhD Degrees:
No. of Master's Degrees:
No. of Bachelor's Degrees:
Human Research Program Elements: (1) ExMC:Exploration Medical Capabilities
Human Research Program Risks: (1) ExMC:Risk of Unacceptable Health and Mission Outcomes Due to Limitations of In-flight Medical Capabilities (IRP Rev E)
Human Research Program Gaps: (1) ExMC 2.01:We do not know the quantified health and mission outcomes due to medical events during exploration missions (IRP Rev E) (Encompassed by Gap Med08 per IRP Rev I)
Flight Assignment/Project Notes: NOTE: Received extension to 1/31/2011, per PI; original end date was 9/30/2010 (Ed., Jan 2011)

Task Description: Since illnesses and injury during space flight pose risks both to crew health and to mission objectives during Space Exploration, these risks must be minimized in multiple ways (e.g., selection criteria, preventative measures, flying appropriate hardware, and procedures). Under this task, the principal investigator produced a software-based decision support tool using an evidence-based approach to delineate clinical strategies for minimizing risks to crew health during space missions.

The Integrated Medical Model (IMM) is designed to identify and quantify crew health risks during flight and to evaluate the effectiveness of in-flight mitigation strategies. The IMM integrates terrestrial and space flight evidence bases to quantify the probability and the consequences of in-flight medical risks using Monte Carlo simulations. Utilizing well accepted scenario driven techniques, such as probabilistic risk analysis, as a guide, IMM generates a set of quantitative measures, such as mission time lost, probability of crew evacuation, and probability of loss of crew life, to enable decision makers to make objective assessment of crew health and mission outcomes with respect to our current level of knowledge.

The current IMM can be used to optimize in-flight medical system capabilities, manage science and technology development portfolios, prioritize crew medical training, and support a variety of “what if” scenarios posed by mission planners. The latest version of the model, IMM 3.0, includes a SQL database and Reference Manager central library, which quantify and document all the clinical evidence used by the IMM.

This interdisciplinary research effort included the establishment of a conceptual framework, the development of an extensive input dataset and SQL database, the development of external models, the creation of simulation and optimization model software, and the design and implementation of novel verification, validation, and configuration management processes.

OBJECTIVES

The IMM Project was tasked to develop an evidence-based, probabilistic decision support tool and integrate the tool in the decision making processes of customers within the Space Life Sciences Directorate (SLSD). The five key objectives of the IMM Project support these overarching goals: 1) develop a software-based, stochastic decision support tool useful to clinical stakeholders and medical mission planners; 2) develop a knowledge management tool for the clinical evidence used by the model; 3) update the medical risk estimates of the Probabalistic Risk Assessment model used by the International Space Station (ISS) Program; 4) develop the ability to optimize the mass and volume for an in-flight medical system and specified level of risk; and 5) help close the communication gaps among science, clinical operations, and engineering communities.

Research Impact/Earth Benefits: The IMM, a product of six years of research, development, and testing, provides NASA a flexible decision support tool for managing human performance and health risks in the harsh, resource-constrained environment of space. The IMM may also find applications in the emerging commercial space flight industry, military missions, maritime and aviation industries, or other remote operations where resources are limited and definitive medical care is not readily available.

The ability to categorize health threats according to crew physiology, crew activities, mission tempo, and mission environment enables prioritized training, space flight systems development, and procedures that result in positive health and mission impacts. IMM can provide a defensible position for making cost-effective decisions regarding crew health, and will help achieve mission success by focusing limited funds on the most relevant health care policies, protocols, and technologies.

Task Progress & Bibliography Information FY2011 
Task Progress: The IMM project was funded from 1 October 2005 to 31 January 2011, at which point the IMM transitioned to an operational tool used by the International Space Station Program to update evacuation and loss of life risk estimates due crew medical events. During the course of development, validation, and transition to operations, both the model data inputs and outputs have aided a broad set of users address in-flight mission and crew health risks, science portfolio allocations, emergency return scenarios, crew training, and in-flight medical system capabilities.

Three key tools created by the IMM Project increase SLSD knowledge management, research, and operational capabilities: 1) IMM Central Library - The IMM Central Library houses all citations and references used to form the clinical basis for each medical condition represented in the IMM. This central library creates the foundation for the SLSD Enterprise-wide Library Solution; 2) IMM Database - The IMM Database is accessible by the SLSD science and clinical operations community. Custom-designed reports can be tailored for each user while automatic notifications will ensure they are aware of the latest additions or alternations; and 3) IMM - The evidence-based, analytic representation of in-flight crew health risk -- in the context of a specific mission and crew profile -- provides an unprecedented capability to communicate clinical risk in engineering-centric programs. The IMM also provides an objective foundation for mission planning dialogue based on evidence and all available relevant data sources.

Bibliography Type: Description: (Last Updated: 04/10/2019) 

Show Cumulative Bibliography Listing
 
Articles in Peer-reviewed Journals Minard CG, de Carvalho MF, Iyengar MS. "Optimizing medical resources for spaceflight using the Integrated Medical Model." Aviat Space Environ Med. 2011 Sep;82(9):890-4. http://dx.doi.org/10.3357/ASEM.3028.2011 ; PubMed PMID: 21888273 , Sep-2011
Awards Butler DJ, Kerstman E, Saile L, Freire de Carvalho M, Minard CG, Lopez V, Bickham G, Walton M. "NASA Johnson Space Center Exceptional Software Award, July 2011." Jul-2011
NASA Technical Documents Fitts MA, Kerstman E, Butler DJ, Walton ME, Minard CG, Saile LG, Toy S, Myers J "The Integrated Medical Model: Statistical Forecasting of Risks to Crew Health and Mission Success." NASA Technical Document, 4 Feb 2008. Internet Archive. Document ID 20080010658. https://ntrs.nasa.gov/archive/nasa/casi.ntrs.nasa.gov/20080010658.pdf , Feb-2008
Papers from Meeting Proceedings Fitts M, Myers J, Kerstman E, Minard CG, Walton M, Butler D, Risin D, Iyengar MS, Johnson-Throop K. "Assessment of Medical Risks and Optimization of Their Management Using the Integrated Medical Model." 59th International Astronautical Congress 2008, Glasgow, Scotland, September 29-October 3, 2008.

IAC paper 2008-2370, September 2008. , Sep-2008

Project Title:  Integrated Medical Model (IMM) Reduce
Fiscal Year: FY 2006 
Division: Human Research 
Research Discipline/Element:
HRP ExMC:Exploration Medical Capabilities
Start Date: 10/01/2005  
End Date: 01/31/2011  
Task Last Updated: 11/24/2009 
Download report in PDF pdf
Principal Investigator/Affiliation:   Butler, Douglas  M.B.A. / Wyle Integrated Science and Engineering 
Address:  1290 Hercules Drive 
 
Houston , TX 77058 
Email: dbutler@wylehou.com 
Phone: 281-212-1380  
Congressional District: 22 
Web:  
Organization Type: NASA CENTER 
Organization Name: Wyle Integrated Science and Engineering 
Joint Agency:  
Comments:  
Project Information: Grant/Contract No. Directed Research 
Responsible Center: NASA JSC 
Grant Monitor: Watkins, Sharmi1a  
Center Contact: 281.483.0395 
sharmila.watkins@nasa.gov 
Solicitation / Funding Source: Directed Research 
Grant/Contract No.: Directed Research 
Project Type: GROUND 
Flight Program:  
TechPort: Yes 
No. of Post Docs:  
No. of PhD Candidates:  
No. of Master's Candidates:  
No. of Bachelor's Candidates:  
No. of PhD Degrees:  
No. of Master's Degrees:  
No. of Bachelor's Degrees:  
Human Research Program Elements: (1) ExMC:Exploration Medical Capabilities
Human Research Program Risks: (1) ExMC:Risk of Unacceptable Health and Mission Outcomes Due to Limitations of In-flight Medical Capabilities (IRP Rev E)
Human Research Program Gaps: (1) ExMC 2.01:We do not know the quantified health and mission outcomes due to medical events during exploration missions (IRP Rev E) (Encompassed by Gap Med08 per IRP Rev I)
Flight Assignment/Project Notes: NOTE: Received extension to 1/31/2011, per PI; original end date was 9/30/2010 (Jan 2011)

Task Description: Introduction

The Integrated Medical Model (IMM) is a decision support tool useful to mission planners and medical system designers in assessing risk and designing medical systems for specified space flight missions. The IMM provides an evidence–based approach to optimize medical resources and minimize risk within space flight operational constraints.

Methods

The mathematical relationships among mission and crew profiles, medical condition incidence data, in-flight medical resources, potential crew functional impairments, and clinical end-states are established to determine probable mission outcomes. Stochastic computational methods are used to forecast probability distributions of crew health and medical resource utilization, as well as estimates of medical evacuation and loss of crew life. The IMM has been used in support of the International Space Station (ISS) medical kit re-design, the medical component of the ISS Probabilistic Risk Assessment, and the development of the Constellation Medical Conditions List. The IMM will also be used to refine medical requirements for the Constellation program.

Discussion

The IMM outputs for ISS and Constellation Design Reference Missions will be presented to demonstrate the potential of the IMM in risk assessment, mission planning and medical system design. The implementation of the IMM verification and validation plan will be reviewed. Additional planned capabilities of the IMM, including optimization techniques and the inclusion of a mission timeline will be discussed.

Conclusions

Given the space flight constraints of mass, volume, and crew medical training, the IMM is a valuable risk assessment and decision support tool for medical system design and mission planning.

Research Impact/Earth Benefits: 0

Task Progress & Bibliography Information FY2006 
Task Progress: New project for FY2006.

[Note: project added to Task Book 11/2009 when received project information]

Bibliography Type: Description: (Last Updated: 04/10/2019) 

Show Cumulative Bibliography Listing
 
 None in FY 2006