Task Progress:
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(Ed. note: updated 8/8/2013; original report 1/4/2011).
The data collection for this project was completed with 12 subjects (8 men, 4 women) participating in exercise testing in both the normovolemic and hypovolemic conditions. In summary, IV furosemide resulted in plasma volume losses in these subjects which were comparable to those observed following long-duration space flight. However, the decrease in aerobic capacity (peak oxygen consumption) was only one half to one third of that observed after space flight. Therefore, space flight-induced decrease in plasma volume contributes to but does not fully explain post-flight reductions in exercise capacity. Because previous reports have suggested that inflight exercise countermeasures can mitigate these losses, other factors related to space flight-induced deconditioning likely contribute to the remaining portion of the post-flight decrease in exercise capacity. A report of these findings was delivered to the Exercise Physiology and Countermeasures Project, and a manuscript is in preparation for potential publication in a peer-reviewed scientific journal.
The pharmacological countermeasures portion of this project was canceled before data collection for that arm of the study was initiated. Therefore, there are no exercise tolerance data related to effects of pharmacological interventions for orthostatic intolerance.
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Abstracts for Journals and Proceedings
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Lee SMC, Everett ME, Ribeiro LC, Martin DS, Westby CM, Stenger MB, Soller BR, Platts SH. "Pharmacologically-induced hypovolemia as a model of post-space flight aerobic capacity." 18th International Academy of Astronautics Humans in Space Symposium, Houston, TX, April 11-15, 2011. 18th IAA Humans in Space Symposium, Houston, TX, April 11-15, 2011. , Apr-2011
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Abstracts for Journals and Proceedings
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Lee SMC, Everett ME, Crowell JB, Westby CM, Soller BR. "NIRS-derived tissue oxygen saturation and hydrogen ion concentration following bed rest." 58th Annual Meeting of the American College of Sports Medicine, Denver, CO, May 31-June 4, 2011. Medicine & Science in Sports & Exercise 2011 May;43(5 Suppl):823. http://dx.doi.org/10.1249/01.MSS.0000402293.26570.88
, May-2011
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Abstracts for Journals and Proceedings
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Soller BR, Lee SMC, Zou F, Scott P, Ellerby GEC, Everett ME, Crowell JB. "Evaluation of skeletal muscle oxygenation during exercise after bed rest and reconditioning." 18th International Academy of Astronautics Humans in Space Symposium, Houston, TX, April 11-15, 2011. 18th IAA Humans in Space Symposium, Houston, TX, April 11-15, 2011. , Apr-2011
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