Task Progress:
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Sixteen medication kits were designed containing identical sets of 35 medications from various dosage forms and therapeutic classes exposed to flight and ground-control environment paradigms. The flight paradigm involved 4 medication kits flown aboard a Shuttle to the International Space Station (ISS). Three flight kits were stored on the ISS and returned to Earth incrementally; while one kit remained on the Shuttle for immediate return 13 days later. Content-indicating assays produced by Ultra and High Performance Liquid Chromatography and physical stability assessments for each medication were performed using methods and testing procedures obtained from the most current version available of the United States Pharmacopoeia or scientific literature. Simultaneous analysis was performed on flight and ground-control kit medications. After 28 month of space exposure, 17 percent of flight kit and 5 percent of ground-control kit medications had changes in appearance; which included discoloration, and phase separation for semi-solid formulations. Nine medications in the flight kits met content acceptance criteria following 28 months of space exposure; which included one aqueous formulation, ciprofloxacin ophthalmic solution, a semi-solid, triamcinolone ointment, and seven solids, acyclovir tablet, atorvastatin tablet, azithromycin tablet, cefadroxil capsule, ibuprofen tablet, imipenem / cilastatin injection powder, and metronidazole tablet. After 28 months of spaceflight, there were medications that failed content requirement in flight, but met it in the control kits; which suggests altered physiochemical stability due to the spaceflight environment.
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Abstracts for Journals and Proceedings
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Du B, Daniels V, Crady C, Boyd J, Putcha L. "Pharmaceutical stability in Space - content analysis." Presented at the Annual meeting and Exposition of the AAPS, Sept. 8-12, 2009. AAPS Journal 2009(S2). , Nov-2009
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Abstracts for Journals and Proceedings
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Chuong MC, Prasad D, LeDuc B, Du B, Putcha L. "Pharmaceutical Stability of Vitamin B Complex in the Outer Space Bioenvironments Retrieved Multivitamin and Multimineral Supplements." Presented at the Annual Meeting and Exposition of the AAPS, November 8-12, 2009. AAPS Journal 2009;11(S2): abstract #1021. http://www.aapsj.org/abstracts/AM_2009/AAPS2009-001021.PDF , Nov-2009
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Articles in Peer-reviewed Journals
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Du B, Daniels VR, Vaksman Z, Boyd JL, Crady C, Putcha L. "Evaluation of physical and chemical changes in pharmaceuticals flown on space missions." AAPS J. 2011 Jun;13(2):299-308. Epub 2011 Apr 9. PMID: 21479701
, Jun-2011
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Articles in Peer-reviewed Journals
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Chuong MC, Prasad D, Leduc B, Du B, Putcha L. "Stability of vitamin B complex in multivitamin and multimineral supplement tablets after space flight." J Pharm Biomed Anal. 2011 Jul 15;55(5):1197-200. Epub 2011 Mar 29. PubMed PMID: 21515013 , Jul-2011
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Articles in Peer-reviewed Journals
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Geimer S, Niemczak CE, Howard PT, Basner M, Buckey JC. "The psychomotor vigilance task for assessing the effects of motion sickness and its treatment." Front Space Technol. 2025 Jun 13;6:1591817. https://doi.org/10.3389/frspt.2025.1591817 , Jun-2025
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