Task Book: Biological & Physical Sciences Division and Human Research Program
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Project Title:  Genomics of Human Bedrest and Exercise Reduce
Fiscal Year: FY 2004 
Division: Human Research 
Research Discipline/Element:
Start Date: 07/01/2001  
End Date: 10/31/2005  
Task Last Updated: 03/24/2006 
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Principal Investigator/Affiliation:   Hamilton, Marc  Ph.D. / University of Missouri 
Address:  1600 East Rollins Road, E 102 Veterinary Medical Building 
Columbia , MO 65211 
Phone: 573-882-6527  
Congressional District:
Organization Type: UNIVERSITY 
Organization Name: University of Missouri 
Joint Agency:  
Project Information: Grant/Contract No. NCC 9-58-MA.002.08 
Responsible Center: NSBRI 
Grant Monitor:  
Center Contact:   
Solicitation: NSBRI 
Grant/Contract No.: NCC 9-58-MA.002.08 
Project Type: GROUND 
Flight Program:  
TechPort: No 
No. of Post Docs:
No. of PhD Candidates:
No. of Master's Candidates:
No. of Bachelor's Candidates:
No. of PhD Degrees:  
No. of Master's Degrees:  
No. of Bachelor's Degrees:  
Human Research Program Elements: None
Human Research Program Risks: None
Human Research Program Gaps: None
Task Description: Unloading of skeletal muscle system through space flight or bed rest causes profound deleterious events in the body. Muscle strength, endurance, and risk of injury are compromised. This project will perform an analysis of the expression of most all the genes expressed in skeletal muscle during unloading, and thereby provide a more global and integrated picture of potential underlying transcriptional mechanisms involved. Using microarray methodology and bioinformatics tools for analysis, these studies will characterize the influence of unloading and exercise on the differential expression of over 33,000 human genes, and in a smaller subset in rats for a translational approach to countermeasure development and comparative validation. The contrast between unloaded muscle and different forms of exercise in the same individuals will provide new insights about the key genes orchestrating the responses to altered energy demand and mechanical loading.

Research Impact/Earth Benefits: Physical inactivity has become a pervasive problem in America that has lead to much greater costs, both in terms of individual human suffering from disease and in terms of the public health care costs associated with chronic diseases such as heart disease, diabetes, obesity, and frailty. Our study aims to uncover some of the root causes explaining how inactivity causes diseases so that better treatments become available. Furthermore, our study aims to compare the efficacy of different exercise treatments targeted toward specific biological defects.

Task Progress & Bibliography Information FY2004 
Task Progress: No progress report this period.

Bibliography Type: Description: (Last Updated: 02/27/2004)  Show Cumulative Bibliography Listing
 None in FY 2004