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Project Title:  Development of Injury Assessment Reference Values for the Neck Applicable to Spaceflight Use Cases Reduce
Images: icon  Fiscal Year: FY 2025 
Division: Human Research 
Research Discipline/Element:
HRP HFBP:Human Factors & Behavioral Performance (IRP Rev H)
Start Date: 07/01/2024  
End Date: 05/31/2026  
Task Last Updated: 04/30/2025 
Download Task Book report in PDF pdf
Principal Investigator/Affiliation:   Weaver, Ashley  Ph.D. / Wake Forest University 
Address:  Biomedical Engineering/ Health Sciences 
575 N Patterson Ave. 
Winston-Salem , NC 27101-4101 
Email: asweaver@wakehealth.edu 
Phone: 336-716-0944  
Congressional District: 12 
Web:  
Organization Type: UNIVERSITY 
Organization Name: Wake Forest University 
Joint Agency:  
Comments:  
Co-Investigator(s)
Affiliation: 
Gayzik, Francis  Ph.D. Wake Forest University 
Hsu, Fang-Chi  Ph.D. Wake Forest University 
Stitzel, Joel  Ph.D. Wake Forest University 
Devane, Karan  Ph.D. Wake Forest University 
Key Personnel Changes / Previous PI: N/A
Project Information: Grant/Contract No. 80NSSC24K1298 
Responsible Center: NASA JSC 
Grant Monitor: Whitmire, Alexandra  
Center Contact:  
alexandra.m.whitmire@nasa.gov 
Unique ID: 16085 
Solicitation / Funding Source: Directed Research 
Grant/Contract No.: 80NSSC24K1298 
Project Type: Ground 
Flight Program:  
TechPort: No 
No. of Post Docs:
No. of PhD Candidates:
No. of Master's Candidates:
No. of Bachelor's Candidates:
No. of PhD Degrees:
No. of Master's Degrees:
No. of Bachelor's Degrees:
Human Research Program Elements: (1) HFBP:Human Factors & Behavioral Performance (IRP Rev H)
Human Research Program Risks: (1) Dynamic Loads:Risk of In-Mission Injury and Performance Decrements and Long-term Health Effects due to Dynamic Loads
Human Research Program Gaps: (1) DL-101:We do not understand the risk of injury associated with crewed vehicle landings and how this risk relates to the desired acceptable risk.
(2) DL-201:We do not know how load dynamics and sex differences affect injury risk in spaceflight conditions and do not have adequate injury assessment reference values (IARVs) to mitigate the increased risk of injury to the crew.
(3) DL-301:We do not have an identified, validated and standardized approach for vehicle instrumentation and biodynamic data collection, and predictive analytic biodynamic modeling that would allow for specific risk injury prediction by mission-phase, crew functionality post-landing, and vehicle design.
Task Description: Injury prediction and prevention in domains analogous to spaceflight dynamic events commonly rely on the use of anthropomorphic test devices (ATD), also known as crash test dummies. While ATDs have been effective in reducing injury in several domains, their use is limited in spaceflight as the dynamic events often involve the use of a seat or spacesuit that may not be compatible with the ATDs, and the dynamic events themselves may not be reproducible in a laboratory setting. Finite element human body models, on the other hand, can be outfitted with a spacesuit and fit into any seat design that may be used. These models can then predict the loads, accelerations, etc., of the body during the dynamic phases of flight. However, the acceptable level of injury risk in spaceflight is much lower than in analogous domains such as the automotive industry. There are currently no established thresholds for which loads on these human body models correspond to these lower levels of injury probability. This task seeks to identify these thresholds, also known as injury assessment reference values (IARVs), for the neck. This process starts by first identifying spaceflight relevant datasets of injurious and noninjurious loading to the neck. Next, the loading conditions from these datasets will be reconstructed with the human body models, and various outputs such as forces, bending moments, and/or stresses will be extracted. These outputs, also known as injury metrics, will then be correlated with the injury data to create injury risk curves. Finally, IARVs will be established, corresponding to the NASA definition of acceptable risk. This will enable more precise prediction of neck injury in a wider range of loading than is currently possible. This is a vital step in reducing injury risk during spaceflight.

Rationale for HRP Directed Research: This task is NASA-directed due to research activities that are time sensitive, and these activities are highly constrained in that they involve working directly with multiple internal NASA programs, including the Human Landing System (HLS) and Orion. The research focuses on defining how the loads a crewmember may experience during unique events such as a lunar landing or surface operations correspond to a certain risk of injury, and it is expected to involve the discussion of proprietary information related to provider vehicles. The Human Physiology, Performance, Protection, and Operations Laboratory (H-3PO) at Johnson Space Center (JSC) has performed research in this area and has working relationships with subject matter experts at Wake Forest, which will make the effort more feasible and acceptable, and as cost-efficient as possible.

Research Impact/Earth Benefits: Protecting the cervical spines of astronauts is critical for mission success. NASA has a very high standard of safety to prevent even minor injuries to the neck. Due to the limited access to medical care in spaceflight missions, injury prevention is highly determined by the ability to predict the risk of injury to the neck in spaceflight conditions. To develop neck injury risk assessments for spaceflight, evaluating lower energy collisions on Earth is essential, as it closely replicates launch and landing conditions. Similarly, neck injuries to vehicle occupants in collisions may be debilitating, especially for those without access to timely medical intervention.

Task Progress & Bibliography Information FY2025 
Task Progress: Phase 1: Literature review (Complete) - Datasets from studies with low-energy impacts on post-mortem human subjects (PMHS), human volunteers, and terrestrial analogs such as sports injuries or automotive impacts were collected and reviewed. The collected data was itemized by injury/non-injury and included injury severity on the abbreviated injury scale (AIS), location, anatomical structure, and mechanism of injury. Boundary conditions and validation data from these experimental studies have been documented to be used in finite element model recreations. A total of 52 cervical spine minor and moderate injuries were counted. The most common cervical spine anatomical structures to be injured in these conditions were facets (n=19), ligaments (n=16), and body fractures (n=11).

Phase 2: Finite Element Reconstruction (Ongoing) – Experimental conditions from studies identified in Phase 1 have been fully recreated for 5 studies, and 1 study is currently in the process of being reconstructed. The Global Human Body Models Consortium (GHBMC) average male simplified occupant model with a deformable spine (M50-OS+DeformSpine) finite element human body model has been adapted and validated for low-level loading conditions relevant to NASA’s risk thresholds. Simulated instrumentation targeting commonly injured cervical anatomy and injury mechanisms has been created. A total of 52 new cervical spine virtual instruments have been added to the GHBMC model bringing the total number to 83 validated instruments. New cervical instruments targeted intervertebral disc, spinous process, and facet cross-sectional forces and motion.

CORrelation and Analysis (CORA) is the main technique for objective evaluation of the performance of the modeling reconstructions, including validation of cervical spine kinetics and kinematics. CORA scores incorporate two main methods of evaluation, cross-correlation rating, and corridor rating. The first method, cross-correlation, is an average of the comparison of magnitude, shape, and phase shift between the experimental data and simulated outputs. The second method, corridor rating, is an objective measure of how well a simulated trace falls between the corridors created by one and two standard deviations in experimental data.

Bibliography: Description: (Last Updated: 05/14/2025) 

Show Cumulative Bibliography
 
Abstracts for Journals and Proceedings Blade S, Mumtaz M, Gayzik FS, Stitzel J, Weaver AA, Devane K. "Development of injury assessment reference values for the neck applicable to spaceflight use cases." 2025 NASA Human Research Program Investigators' Workshop, Galveston, Texas, January 28-31, 2025.

Abstracts. 2025 NASA Human Research Program Investigators' Workshop, Galveston, Texas, January 28-31, 2025. , Jan-2025

Abstracts for Journals and Proceedings Blade S, Mumtaz M, Edwards C, Gayzik FS, Stitzel J, Weaver AA, Devane K. "Development of injury assessment reference values for the neck applicable to spaceflight use cases." 2025 Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences Graduate Research Symposium, Blacksburg, Virginia, April 28, 2025.

Abstracts. 2025 Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences Graduate Research Symposium, Blacksburg, Virginia, April 28, 2025. , Apr-2025

Project Title:  Development of Injury Assessment Reference Values for the Neck Applicable to Spaceflight Use Cases Reduce
Images: icon  Fiscal Year: FY 2024 
Division: Human Research 
Research Discipline/Element:
HRP HFBP:Human Factors & Behavioral Performance (IRP Rev H)
Start Date: 07/01/2024  
End Date: 05/31/2026  
Task Last Updated: 08/08/2024 
Download Task Book report in PDF pdf
Principal Investigator/Affiliation:   Weaver, Ashley  Ph.D. / Wake Forest University 
Address:  Biomedical Engineering/ Health Sciences 
575 N Patterson Ave. 
Winston-Salem , NC 27101-4101 
Email: asweaver@wakehealth.edu 
Phone: 336-716-0944  
Congressional District: 12 
Web:  
Organization Type: UNIVERSITY 
Organization Name: Wake Forest University 
Joint Agency:  
Comments:  
Co-Investigator(s)
Affiliation: 
Gayzik, Francis  Ph.D. Wake Forest University 
Hsu, Fang-Chi  Ph.D. Wake Forest University 
Stitzel, Joel  Ph.D. Wake Forest University 
Devane, Karan  Ph.D. Wake Forest University 
Project Information: Grant/Contract No. 80NSSC24K1298 
Responsible Center: NASA JSC 
Grant Monitor: Whitmire, Alexandra  
Center Contact:  
alexandra.m.whitmire@nasa.gov 
Unique ID: 16085 
Solicitation / Funding Source: Directed Research 
Grant/Contract No.: 80NSSC24K1298 
Project Type: Ground 
Flight Program:  
TechPort: No 
No. of Post Docs:  
No. of PhD Candidates:
No. of Master's Candidates:  
No. of Bachelor's Candidates:  
No. of PhD Degrees:  
No. of Master's Degrees:  
No. of Bachelor's Degrees:  
Human Research Program Elements: (1) HFBP:Human Factors & Behavioral Performance (IRP Rev H)
Human Research Program Risks: (1) Dynamic Loads:Risk of In-Mission Injury and Performance Decrements and Long-term Health Effects due to Dynamic Loads
Human Research Program Gaps: (1) DL-101:We do not understand the risk of injury associated with crewed vehicle landings and how this risk relates to the desired acceptable risk.
(2) DL-201:We do not know how load dynamics and sex differences affect injury risk in spaceflight conditions and do not have adequate injury assessment reference values (IARVs) to mitigate the increased risk of injury to the crew.
(3) DL-301:We do not have an identified, validated and standardized approach for vehicle instrumentation and biodynamic data collection, and predictive analytic biodynamic modeling that would allow for specific risk injury prediction by mission-phase, crew functionality post-landing, and vehicle design.
Task Description: Injury prediction and prevention in domains analogous to spaceflight dynamic events commonly rely on the use of anthropomorphic test devices (ATD), also known as crash test dummies. While ATDs have been effective in reducing injury in several domains, their use is limited in spaceflight as the dynamic events often involve the use of a seat or spacesuit that may not be compatible with the ATDs, and the dynamic events themselves may not be reproducible in a laboratory setting. Finite element human body models, on the other hand, can be outfitted with a spacesuit and fit into any seat design that may be used. These models can then predict the loads, accelerations, etc., of the body during the dynamic phases of flight. However, the acceptable level of injury risk in spaceflight is much lower than in analogous domains such as the automotive industry. There are currently no established thresholds for which loads on these human body models correspond to these lower levels of injury probability. This task seeks to identify these thresholds, also known as injury assessment reference values (IARVs), for the neck. This process starts by first identifying spaceflight relevant datasets of injurious and noninjurious loading to the neck. Next, the loading conditions from these datasets will be reconstructed with the human body models, and various outputs such as forces, bending moments, and/or stresses will be extracted. These outputs, also known as injury metrics, will then be correlated with the injury data to create injury risk curves. Finally, IARVs will be established, corresponding to the NASA definition of acceptable risk. This will enable more precise prediction of neck injury in a wider range of loading than is currently possible. This is a vital step in reducing injury risk during spaceflight.

Rationale for HRP Directed Research: This task is NASA-directed due to research activities that are time sensitive, and these activities are highly constrained in that they involve working directly with multiple internal NASA programs, including the Human Landing System (HLS) and Orion. The research focuses on defining how the loads a crewmember may experience during unique events such as a lunar landing or surface operations correspond to a certain risk of injury, and it is expected to involve the discussion of proprietary information related to provider vehicles. The Human Physiology, Performance, Protection, and Operations Laboratory (H-3PO) at Johnson Space Center (JSC) has performed research in this area and has working relationships with subject matter experts at Wake Forest, which will make the effort more feasible and acceptable, and as cost-efficient as possible.

Research Impact/Earth Benefits:

Task Progress & Bibliography Information FY2024 
Task Progress: New Project FY2024

Bibliography: Description: (Last Updated: 05/14/2025) 

Show Cumulative Bibliography
 
 None in FY 2024