Phycoremediation leverages microalgae to remove harmful components from substrates and has been used to treat contaminated soils and wastewater, to include the removal of heavy metals. These microorganisms are powered by photosynthesis, consuming carbon dioxide and generating oxygen in the process, with few other resources required. We hypothesize that heavy metal stress is a primary inhibitor of plant growth in regolith and that this stress can be mitigated by bioremediation with photosynthetic microorganisms. We are proposing a study to assess whether the cyanobacterium Arthrospira platensis (A. platensis; common name: spirulina) can process lunar regolith into a soil suitable for crop production. We intend to combine photosynthetic metabolic modeling to optimize cyanobacterial growth on regolith, assess the ability of A. platensis to capture heavy metals, and evaluate plant growth in the remediated regolith. Our proposed work to render lunar regolith more conducive to in situ agriculture supports NASA’s Moon to Mars objectives and NASA’s Space Biology Science Plan.