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Project Title:  Sex-Specific Physiological and Transcriptomic CNS Responses to Combined Effects of Spaceflight Stressors in Drosophila melanogaster Reduce
Images: icon  Fiscal Year: FY 2023 
Division: Space Biology 
Research Discipline/Element:
Space Biology: Cell & Molecular Biology   | Animal Biology: Invertebrate  
Start Date: 05/01/2023  
End Date: 04/30/2024  
Task Last Updated: 10/03/2023 
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Principal Investigator/Affiliation:   Iyer, Janani  Ph.D. / NASA Ames Research Center 
Address:  Universities Space Research Association 
Building N288, Room 202A 
Moffett Field , CA 94035 
Email: iyerjan@gmail.com 
Phone: 425-301-9112  
Congressional District: 16 
Web:  
Organization Type: NASA CENTER 
Organization Name: NASA Ames Research Center 
Joint Agency:  
Comments:  
Co-Investigator(s)
Affiliation: 
Ronca, April  Ph.D. NASA Ames Research Center 
Mhatre, Siddhita  Ph.D. NASA Ames Research Center 
Project Information: Grant/Contract No. Internal Project 
Responsible Center: NASA ARC 
Grant Monitor: Griko, Yuri  
Center Contact: 650-604-0519 
Yuri.V.Griko@nasa.gov 
Unique ID: 15651 
Solicitation / Funding Source: 2021 Space Biology NNH21ZDA001N-SBAS E.11: Animal Studies 
Grant/Contract No.: Internal Project 
Project Type: GROUND 
Flight Program:  
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Space Biology Element: (1) Cell & Molecular Biology
(2) Animal Biology: Invertebrate
Space Biology Cross-Element Discipline: (1) Neurobiology
Space Biology Special Category: None
Task Description: During space exploration, damage to the central nervous system (CNS) due to altered gravity is a significant risk, along with the constant exposure to elevated CO2 levels. The combination of these stressors can negatively impact the CNS health that may lead to decrements in astronaut performance, posing a risk to the crew and the mission. Thus, there is an unmet need to unravel the mechanisms and pathways affected by these combined spaceflight stressors. In this proposal, we aim to address sex-specific and long-term responses to spaceflight stressors (mimicking the longitudinal post-flight evaluations in astronauts). We will perform behavioral, brain morphological, and biochemical assays, along with cell-specific transcriptomic profiling in Drosophila melanogaster to investigate the underlying mechanistic responses to single and combined exposures of altered gravity and elevated CO2. While this solicitation is limited in time and scope, we anticipate that our findings from this study will inform future investigations in vertebrate models and contribute to new research that will address the biomedical outcomes of deep space stressors.

Research Impact/Earth Benefits:

Task Progress & Bibliography Information FY2023 
Task Progress: New project for FY2023.

Bibliography: Description: (Last Updated: ) 

Show Cumulative Bibliography
 
 None in FY 2023