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Project Title:  Acute and Long-Term Effects of Combined Radiation and Partial Unloading on Neurological and Musculoskeletal Systems in Male and Female Rats Reduce
Images: icon  Fiscal Year: FY 2024 
Division: Space Biology 
Research Discipline/Element:
Space Biology: Animal Biology: Vertebrate  
Start Date: 06/01/2023  
End Date: 05/31/2026  
Task Last Updated: 04/05/2024 
Download report in PDF pdf
Principal Investigator/Affiliation:   Rutkove, Seward  M.D. / Beth Israel Deaconess Medical Center, Inc./Harvard Medical School 
Address:  330 Brookline Ave TCC-810  
 
Boston , MA 02215-5400 
Email: srutkove@bidmc.harvard.edu 
Phone: 617-667-8130  
Congressional District:
Web:  
Organization Type: UNIVERSITY 
Organization Name: Beth Israel Deaconess Medical Center, Inc./Harvard Medical School 
Joint Agency:  
Comments:  
Co-Investigator(s)
Affiliation: 
Bouxsein, Mary  Ph.D. Beth Israel Deaconess Medical Center, Inc. 
Mortreux, Marie  Ph.D. Beth Israel Deaconess Medical Center, Inc. 
Lemere, Cynthia  Ph.D. Brigham And Women's Hospital, Inc. 
Key Personnel Changes / Previous PI: There are no changes.
Project Information: Grant/Contract No. 80NSSC23K0774 
Responsible Center: NASA ARC 
Grant Monitor: Griko, Yuri  
Center Contact: 650-604-0519 
Yuri.V.Griko@nasa.gov 
Unique ID: 15529 
Solicitation / Funding Source: 2021 Space Biology NNH21ZDA001N-SBAS E.11: Animal Studies 
Grant/Contract No.: 80NSSC23K0774 
Project Type: GROUND 
Flight Program:  
No. of Post Docs:
No. of PhD Candidates:
No. of Master's Candidates:
No. of Bachelor's Candidates:
No. of PhD Degrees:
No. of Master's Degrees:
No. of Bachelor's Degrees:
Space Biology Element: (1) Animal Biology: Vertebrate
Space Biology Cross-Element Discipline: (1) Musculoskeletal Biology
(2) Neurobiology
Space Biology Special Category: None
Task Description: In this proposed work, we will evaluate the separate and combined effects of simulated space radiation and lunar gravity on the muscular, skeletal, and central nervous systems over the short- and longer-term. Moreover, we will assess whether these effects differ by biological sex. This work will be accomplished by studying male and female rats of an age (in rat years) comparable to that of the astronaut corps and exposing them simultaneously to simulated galactic cosmic rays (Galactic Cosmic Rays simulation: GCRsim) at Brookhaven National Laboratory and extended 20% partial weight-bearing to mimic lunar gravity. Animals will be assessed after completing 28 days of partial weight-bearing to assess short-term effects of these exposures and several months later to assess longer-term effects with recovery. This will include a variety of functional, molecular, and histological assessments assessing bone, muscle, and brain.

This project is aligned with recommendations listed in the Decadal Survey, specifically: AH2) Preservation and reversibility of bone structure and strength; AH5) understanding underlying mechanisms regulating net skeletal muscle protein balance and protein turnover during states of unloading and recovery; and AH9) Investigate the effects of prolonged reduced gravity on task completion; B2) Conduct integrated translational research in which long-duration missions are simulated specifically for the purpose of studying the interrelationships among individual functioning and cognitive performance.

Deliverables: This proposal will provide new data on the sex-specific effects of combined lunar gravity and galactic cosmic ray exposure on Central Nervous System (CNS) and musculoskeletal health to help us prepare more effectively for future extended lunar missions.

Research Impact/Earth Benefits: This project will provide valuable insights the impact of reduced muscle loading (as would occur here on Earth when using crutches or a walker) on longer term motor function, including muscle, skeletal, and brain health and cognition. It will also evaluate the effects of radiation exposure on muscle, skeletal, and brain health and cognition, which could have relevance to patients being treated with radiotherapy for various cancers or being inadvertently exposed to radiation (in an industrial exposure or accident). Moreover, it will evaluate the effect of these two stressors together, which is certainly not an uncommon situation in patients who are debilitated while receiving radiotherapy for neoplastic disease.

Task Progress & Bibliography Information FY2024 
Task Progress: In this first year of funding, we have put in place all our plans for a Spring 2024 campaign at Brookhaven National Laboratory to begin in mid-April, 2024.

We have spent the past 10 months preparing for this first campaign, including organizing the complexities of animal studies, deliveries, equipment and supplies, and housing. We are now ready to begin the work and look forward to completing the experiments as outlined in the proposal for the first set of animals (female). This work will include the short-term and long-term animals, the latter being the ones that will be returned to our home institution (Beth Israel Deaconess Medical Center, Boston, MA) and followed for 3 additional months before terminal measurements are made. We anticipate that following this work (in Fall 2024 and Winter 2025) we will complete all histological and additional analyses on this first cohort and will be ready to proceed with the second planned cohort in the Spring 2025 Brookhaven National Laboratory experimental session.

Bibliography: Description: (Last Updated: 03/05/2024) 

Show Cumulative Bibliography
 
 None in FY 2024
Project Title:  Acute and Long-Term Effects of Combined Radiation and Partial Unloading on Neurological and Musculoskeletal Systems in Male and Female Rats Reduce
Images: icon  Fiscal Year: FY 2023 
Division: Space Biology 
Research Discipline/Element:
Space Biology: Animal Biology: Vertebrate  
Start Date: 06/01/2023  
End Date: 05/31/2026  
Task Last Updated: 06/13/2023 
Download report in PDF pdf
Principal Investigator/Affiliation:   Rutkove, Seward  M.D. / Beth Israel Deaconess Medical Center, Inc./Harvard Medical School 
Address:  330 Brookline Ave TCC-810  
 
Boston , MA 02215-5400 
Email: srutkove@bidmc.harvard.edu 
Phone: 617-667-8130  
Congressional District:
Web:  
Organization Type: UNIVERSITY 
Organization Name: Beth Israel Deaconess Medical Center, Inc./Harvard Medical School 
Joint Agency:  
Comments:  
Co-Investigator(s)
Affiliation: 
Bouxsein, Mary  Ph.D. Beth Israel Deaconess Medical Center, Inc. 
Mortreux, Marie  Ph.D. Beth Israel Deaconess Medical Center, Inc. 
Lemere, Cynthia  Ph.D. Brigham And Women's Hospital, Inc. 
Project Information: Grant/Contract No. 80NSSC23K0774 
Responsible Center: NASA ARC 
Grant Monitor: Griko, Yuri  
Center Contact: 650-604-0519 
Yuri.V.Griko@nasa.gov 
Unique ID: 15529 
Solicitation / Funding Source: 2021 Space Biology NNH21ZDA001N-SBAS E.11: Animal Studies 
Grant/Contract No.: 80NSSC23K0774 
Project Type: GROUND 
Flight Program:  
No. of Post Docs:  
No. of PhD Candidates:  
No. of Master's Candidates:  
No. of Bachelor's Candidates:  
No. of PhD Degrees:  
No. of Master's Degrees:  
No. of Bachelor's Degrees:  
Space Biology Element: (1) Animal Biology: Vertebrate
Space Biology Cross-Element Discipline: (1) Musculoskeletal Biology
(2) Neurobiology
Space Biology Special Category: None
Task Description: In this proposed work, we will evaluate the separate and combined effects of simulated space radiation and lunar gravity on the muscular, skeletal, and central nervous systems over the short- and longer-term. Moreover, we will assess whether these effects differ by biological sex. This work will be accomplished by studying male and female rats of an age (in rat years) comparable to that of the astronaut corps and exposing them simultaneously to simulated galactic cosmic rays (Galactic Cosmic Rays simulation: GCRsim) at Brookhaven National Laboratory and extended 20% partial weight-bearing to mimic lunar gravity. Animals will be assessed after completing 28 days of partial weight-bearing to assess short-term effects of these exposures and several months later to assess longer-term effects with recovery. This will include a variety of functional, molecular, and histological assessments assessing bone, muscle, and brain.

This project is aligned with recommendations listed in the Decadal Survey, specifically: AH2) Preservation and reversibility of bone structure and strength; AH5) understanding underlying mechanisms regulating net skeletal muscle protein balance and protein turnover during states of unloading and recovery; and AH9) Investigate the effects of prolonged reduced gravity on task completion; B2) Conduct integrated translational research in which long-duration missions are simulated specifically for the purpose of studying the interrelationships among individual functioning and cognitive performance.

Deliverables: This proposal will provide new data on the sex-specific effects of combined lunar gravity and galactic cosmic ray exposure on Central Nervous System (CNS) and musculoskeletal health to help us prepare more effectively for future extended lunar missions.

Research Impact/Earth Benefits: This project is aligned with recommendations listed in the Decadal Survey, specifically: AH2) Preservation and reversibility of bone structure and strength; AH5) understanding underlying mechanisms regulating net skeletal muscle protein balance and protein turnover during states of unloading and recovery; and AH9) Investigate the effects of prolonged reduced gravity on task completion; B2) Conduct integrated translational research in which long-duration missions are simulated specifically for the purpose of studying the interrelationships among individual functioning and cognitive performance.

Task Progress & Bibliography Information FY2023 
Task Progress: New project for FY2023.

Bibliography: Description: (Last Updated: 03/05/2024) 

Show Cumulative Bibliography
 
 None in FY 2023