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Project Title:  Effect of Head-Down Tilt +/- CO2 on Human Glymphatic Function Reduce
Images: icon  Fiscal Year: FY 2023 
Division: Human Research 
Research Discipline/Element:
HRP HHC:Human Health Countermeasures
Start Date: 01/06/2023  
End Date: 01/05/2024  
Task Last Updated: 02/20/2023 
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Principal Investigator/Affiliation:   Seidler, Rachael D. Ph.D. / University of Florida 
Address:  Applied Physiology & Kinesiology 
FLG 142, P.O. Box 118205 
Gainesville , FL 32611-8205 
Phone: 352-294-1722  
Congressional District:
Organization Type: UNIVERSITY 
Organization Name: University of Florida 
Joint Agency:  
Comments: NOTE: PI moved to University of Florida in July 2017; previous affiliation was University of Michigan.  
Richmond, Sutton  Ph.D. University of Florida, Gainesville 
Roy, Arkaprava  Ph.D. University of Florida, Gainesville 
Project Information: Grant/Contract No. 80NSSC23K0365 
Responsible Center: NASA JSC 
Grant Monitor: Stenger, Michael  
Center Contact: 281-483-1311 
Unique ID: 15396 
Solicitation / Funding Source: 2020 HERO 80JSC020N0001-FLAGSHIP, OMNIBUS1 Human Research Program: Crew Health Appendix A; Omnibus1-Appendix B 
Grant/Contract No.: 80NSSC23K0365 
Project Type: GROUND 
Flight Program:  
TechPort: No 
No. of Post Docs:  
No. of PhD Candidates:  
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Human Research Program Elements: (1) HHC:Human Health Countermeasures
Human Research Program Risks: None
Human Research Program Gaps: None
Task Description: Spaceflight Associated Neuro-ocular Syndrome (SANS) is a potentially mission-limiting condition for astronauts, yet its underlying pathophysiology is poorly understood. It has been proposed that impairment of the glymphatic system in response to fluid shift or venous congestion could be an underlying cause of SANS. However, there have been no studies to date evaluating human glymphatic function in response to simulated microgravity. While our team is currently evaluating the effect of elevated carbon dioxide (CO2) on human glymphatic function (awards from NASA and the Office of Naval Research), we have yet to evaluate the spaceflight-relevant combination of CO2 and simulated microgravity. (Ed. Note: See related Grant #80NSSC17K0021--PI: Seidler). The latter can be achieved via 6° head-down tilt (HDT), simulating the headward fluid shifts of microgravity. Here, we propose to conduct glymphatic magnetic resonance imaging (MRI) in human subjects over a span of several hours while they are either supine or lying on a 6° foam wedge with head-down tilt. They will also be breathing elevated CO2 to better mimic the conditions on the International Space Station. We will measure the effects of HDT positioning on human glymphatic function (Aim 1) and the combined effects of breathing elevated CO2 and HDT on human glymphatic function (Aim 2). Thus, we will quantify the acute effects HDT with and without elevated CO2.

Research Impact/Earth Benefits:

Task Progress & Bibliography Information FY2023 
Task Progress: New project for FY2023.

Bibliography: Description: (Last Updated: 08/10/2023) 

Show Cumulative Bibliography
 None in FY 2023