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Project Title:  Ultra-Compact Urinary Calcium Measurement Device: Refinement and Application Reduce
Images: icon  Fiscal Year: FY 2022 
Division: Human Research 
Research Discipline/Element:
HRP ExMC:Exploration Medical Capabilities
Start Date: 03/28/2022  
End Date: 03/27/2023  
Task Last Updated: 06/15/2022 
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Principal Investigator/Affiliation:   Lan, Li-i   / Dartmouth College 
Address:  Thayer School of Engineering 
HB 7000 Hinman 
Hanover , NH 03755 
Phone: 949-798-9247  
Congressional District:
Organization Type: UNIVERSITY 
Organization Name: Dartmouth College 
Joint Agency:  
Buckey, Jay  M.D. Dartmouth College 
Devoy, Clive  Creare LLC 
Phillips, Scott  Ph.D. Creare LLC 
Knaus, Darin  Ph.D. Creare LLC 
Project Information: Grant/Contract No. 80NSSC22K0847 
Responsible Center: NASA JSC 
Grant Monitor: Lehnhardt, Kris  
Center Contact: 281.244.0524 
Unique ID: 15019 
Solicitation / Funding Source: 2020 HERO 80JSC020N0001-FLAGSHIP, OMNIBUS1 Human Research Program: Crew Health Appendix A; Omnibus1-Appendix B 
Grant/Contract No.: 80NSSC22K0847 
Project Type: GROUND 
Flight Program:  
TechPort: No 
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Human Research Program Elements: (1) ExMC:Exploration Medical Capabilities
Human Research Program Risks: (1) Bone Fracture:Risk of Bone Fracture due to Spaceflight-induced Changes to Bone (IRP Rev M)
(2) Renal:Risk of Renal Stone Formation
Human Research Program Gaps: (1) B08:Do pharmaceuticals work effectively in spaceflight to prevent renal stones?
(2) Osteo05:We need an inflight capability to monitor bone turnover and bone mass changes during spaceflight (IRP Rev E)
Task Description: Slowing bone loss and preventing kidney stone formation are critical for successful spaceflight. The capability to track bone loss and kidney stone risk while in space would allow these risks to be monitored directly and would enable individualized countermeasure programs. At present, post-flight measurements are used to establish the effectiveness of the in-flight bone loss/kidney stone prevention program. A preventive approach would offer much greater operational flexibility, where ongoing in-flight measurements of countermeasure effectiveness would allow for adjustments in the countermeasure program during the flight. This approach could also be used during times when countermeasure equipment is broken, or when scheduling impacts the countermeasure program, to assess how this is affecting bone loss and kidney stone risk. In a previous NASA Omnibus project, we developed a prototype compact, low-power system to make urinary calcium measurements in space. This approach has proven to be feasible, but further development is needed to advance toward flight use.

The objective of the current project is to improve this ultra-compact, robust, urinary calcium measurement system. This study will further a technology that may offer a personalized, preventive approach to bone loss and kidney stone prevention in space.

Research Impact/Earth Benefits:

Task Progress & Bibliography Information FY2022 
Task Progress: New project for FY2022.

Bibliography Type: Description: (Last Updated: ) 

Show Cumulative Bibliography Listing
 None in FY 2022