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Project Title:  Validation of Multisystem Countermeasures Protocol for Spaceflight during Antarctica Winter-over at Palmer Station Reduce
Images: icon  Fiscal Year: FY 2021 
Division: Human Research 
Research Discipline/Element:
HRP HHC:Human Health Countermeasures
Start Date: 03/03/2021  
End Date: 03/02/2026  
Task Last Updated: 03/25/2022 
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Principal Investigator/Affiliation:   Crucian, Brian  Ph.D. / NASA Johnson Space Center 
Address:  Immunology, SK4 
2101 NASA Pkwy 
Houston , TX 77058-3607 
Email: brian.crucian-1@nasa.gov 
Phone: 281-483-7061  
Congressional District: 36 
Web:  
Organization Type: NASA CENTER 
Organization Name: NASA Johnson Space Center 
Joint Agency:  
Comments:  
Co-Investigator(s)
Affiliation: 
Makedonas, George  Ph.D. NASA Johnson Space Center 
Krieger, Stephanie  M.S. KBR/NASA Johnson Space Center 
Nelman-Gonzalez, Mayra  B.A. NASA Johnson Space Center 
Mehta, Satish  Ph.D. KBR/NASA Johnson Space Center 
Smith, Scott  Ph.D. NASA Johnson Space Center 
Zwart, Sara  Ph.D. NASA Johnson Space Center 
Chouker, Alexander  Ph.D. University of Munich, Germany 
Ponomarev, Sergey  M.D., Ph.D. Institute of Biomedical Problems (IBMP), Moscow, Russia 
Simpson, Richard  Ph.D. University of Arizona 
Stowe, Raymond  Ph.D. Microgen Laboratories 
Wallace, Sara  Ph.D. NASA Johnson Space Center 
Mercaldo, Nathaniel  Ph.D. NASA Johnson Space Center 
Douglas, Grace  Ph.D. NASA Johnson Space Center 
Downs, Meghan  Ph.D. NASA Johnson Space Center 
Loisel, Dagan  Ph.D. St. Michael's College 
VanderKaay Tomasulo, Melissa  Ph.D. St. Michael's College 
Aunon-Chancellor, Serena  MD NASA Johnson Space Center 
Marshall, Gailen  M.D., Ph.D. University of Mississippi 
Orange, Jordan  M.D., Ph.D. Columbia University 
Gershon, Anne  M.D. Columbia University 
Project Information: Grant/Contract No. Directed Research 
Responsible Center: NASA JSC 
Grant Monitor: Stenger, Michael  
Center Contact: 281-483-1311 
michael.b.stenger@nasa.gov 
Solicitation / Funding Source: Directed Research 
Grant/Contract No.: Directed Research 
Project Type: GROUND 
Flight Program:  
TechPort: No 
No. of Post Docs:  
No. of PhD Candidates:  
No. of Master's Candidates:  
No. of Bachelor's Candidates:  
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Human Research Program Elements: (1) HHC:Human Health Countermeasures
Human Research Program Risks: (1) Immune:Risk of Adverse Health Event Due to Altered Immune Response (IRP Rev F)
Human Research Program Gaps: (1) IM-105:Identify immune biomarkers that correlate with known spaceflight-related immune dysfunction and immune outcomes, as a first step in designing in-flight monitoring paradigms (IRP Rev L)
(2) IM-201:Based on immune dysfunction biomarkers identified in Scientific Objective 1, identify, develop, and implement in-flight immune function monitoring tools for support of research during Gateway, Lunar, and Mars missions (IRP Rev L)
(3) IM-301: Identify appropriate ground-based analogs to spaceflight-induced immune dysfunction to enable ground validation of preventive/mitigative countermeasures and derive mechanistic insights (IRP Rev L)
(4) IM-401:Test, optimize and validate nutrition-based preventive/mitigative countermeasures (IRP Rev L)
(5) IM-403:Test, optimize and validate stress reduction techniques as preventive and mitigative immune dysfunction countermeasures (IRP Rev L)
(6) IM-501:Test the finalized, integrated, multi-component immune countermeasure in flight (IRP Rev L)
Task Description: Low-Earth orbital spaceflight perturbs the human immune system persistently, characterized by reductions in T and NK cell function, altered cytokine profiles, and the reactivation of latent herpesviruses. While these alterations have not caused widespread clinical issues, some crewmembers experience immune-related adverse events, including manifestations of herpes virus reactivation, other infectious diseases, and atopic dermatitis. Because future deep-space exploration missions will be of unprecedented duration, it is reasonable to hypothesize that the immune perturbations observed aboard the International Space Station (ISS) will intensify during longer missions in deep space, thereby placing crewmembers at elevated clinical risk. Thus, it is imperative to preserve the immunocompetence of astronauts by developing a countermeasure strategy operationally compatible (mass, power, crew time, etc.) with implementation during deep space missions of exploration.

An international team of interdisciplinary scientists has developed a candidate multisystem immune countermeasure protocol ready to test for efficacy, consisting of diet modification, nutritional supplementation, prescribed aerobic and resistive exercise, and a set of stress-relieving exercises implemented using a virtual reality headset. The isolation, extreme environment, prolonged duration, and various mission-associated stressors suggest the best Earth analog for spaceflight-induced immune dysregulation is likely to be Antarctica winter-over. Amongst the various Antarctic stations, one with small (ISS-like) crew size and normoxic (coastal) conditions would be superior to evaluate the NASA countermeasure. The United States maintains three primary stations on Antarctica: Amundsen-Scott South Pole Station, McMurdo Station, and Palmer Station, of which only Palmer possesses and induces the desired characteristics that are most similar to the ISS. In this study, we will implement the countermeasure protocol to a cohort of subjects for three consecutive Antarctica winter-over sessions (2 countermeasure, 1 control session) at Palmer.

Hypothesis: Implementation of a ‘suite’ of interdisciplinary biomedical countermeasures will positively rectify any immune dysregulation induced by the Palmer Antarctica spaceflight analog. This study will therefore validate the countermeasures suite prior to a potential flight validation aboard the ISS, and utilization during upcoming deep space missions.

Aims:

(1) To determine if the complete immune countermeasure protocol developed for spaceflight ameliorates the detrimental effect of coastal Antarctica winter-over, as a relevant ground analog for deep space missions, on a variety of physiological biomarkers. The primary aim involves the quantification of the association between immunologic/virologic biomarkers and usage of the countermeasure protocol.

(2) To analyze the specific components of the protocol (e.g., nutrition, innate immunity, stress, etc.) and other biomarkers of interest. The experimental assays will consist of the previously validated measures that define immune dysregulation in astronauts.

Rationale for HRP Directed Research: This research is directed because it contains highly constrained research.

1) Time to Implementation: Winter-over missions on Antarctica are yearlong deployments, which means opportunities to implement science there occur once a year. Initiating this project, concurrent with the planned NASA Johnson Space Center (JSC) Research and Clinical Advisory Panel/Technical Interchange Meeting (RCAP/TIM), will expedite our ability to meet the Production Readiness Review (PRR) schedule for upcoming ground and flight validation of immune countermeasures. External solicitations would introduce unnecessary cost and delay study implementation, potentially by two years.

2) Technical homology: The same measurements that have been used to define immune dysregulation during long-duration spaceflight will be used in this study to assess the efficacy of the countermeasure protocol. Furthermore, this constant set of parameters will be a valuable dataset against which to compare additional, cutting-edge means of immune surveillance. Without the consistency across studies, the result will be independent datasets, from which it will be impossible to formulate conclusions about the biological mechanisms at play. Many of the immune assays and endpoints included here have been validated during previous flight studies. To solicit for assays externally would invite technical differences from the flight studies that have defined immune dysregulation among astronauts in space, and produce a negative effect on data correlation.

3) Validated sample processing protocols: The research teams listed in this proposal have already optimized and validated the protocols to ensure proper biological sample collection, stability, and storage under the operational constraints of fieldwork in Antarctica.

4) Established collaborations: The NASA JSC investigators have a documented work relationship with the American and international partner immunologists listed in the protocol, which will expedite the execution of the study and ensure rapid and open communication between the teams.

5) Implementation Aspects: For a complicated medical study with unique sampling constraints, it is advantageous to have an in-house investigator lead the study to success. Examples of this notion include central coordination of sample storage and sharing; facilitation of data collection, storage, analyses, and sharing; and physical proximity of interdisciplinary laboratories (Nutrition, Food, Exercise, and Microbiology), which promotes communication.

Research Impact/Earth Benefits:

Task Progress & Bibliography Information FY2021 
Task Progress: New project for FY2021.

Bibliography Type: Description: (Last Updated: 09/15/2020) 

Show Cumulative Bibliography Listing
 
 None in FY 2021