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Project Title:  Mitigating Headward Fluid Shifts with Veno-Constrictive Thigh Cuffs During Spaceflight Reduce
Images: icon  Fiscal Year: FY 2021 
Division: Human Research 
Research Discipline/Element:
HRP HHC:Human Health Countermeasures
Start Date: 05/15/2021  
End Date: 05/14/2026  
Task Last Updated: 06/30/2021 
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Principal Investigator/Affiliation:   Macias, Brandon  Ph.D. / NASA Johnson Space Center 
Address:  Johnson Space Center Cardiovascular and Vision Laboratory 
2101 NASA Parkway, HAC/B21N-1207 
Houston , TX 77058 
Email: brandon.r.macias@nasa.gov 
Phone: 281-483-2026  
Congressional District: 36 
Web:  
Organization Type: NASA CENTER 
Organization Name: NASA Johnson Space Center 
Joint Agency:  
Comments: NOTE: Became civil servant fall 2020; previously KBR/NASA Johnson Space Center. Prior to that until 2016, was at the University of California, San Diego. 
Co-Investigator(s)
Affiliation: 
Laurie, Steven  Ph.D. KBR/NASA Johnson Space Center 
Marshall-Goebel, Karina  Ph.D. KBR/NASA Johnson Space Center 
Lee, Stuart  Ph.D. KBR/NASA Johnson Space Center 
Jasien, Jessica  Ph.D. JES/NASA Johnson Space Center 
Cole, Chris  Ph.D. Clemson University 
Foulk, Jonn  Ph.D. Clemson University 
Project Information: Grant/Contract No. Directed Research 
Responsible Center: NASA JSC 
Grant Monitor: Stenger, Michael  
Center Contact: 281-483-1311 
michael.b.stenger@nasa.gov 
Solicitation / Funding Source: Directed Research 
Grant/Contract No.: Directed Research 
Project Type: FLIGHT,GROUND 
Flight Program: ISS 
TechPort: No 
No. of Post Docs:  
No. of PhD Candidates:  
No. of Master's Candidates:  
No. of Bachelor's Candidates:  
No. of PhD Degrees:  
No. of Master's Degrees:  
No. of Bachelor's Degrees:  
Human Research Program Elements: (1) HHC:Human Health Countermeasures
Human Research Program Risks: (1) SANS:Risk of Spaceflight Associated Neuro-ocular Syndrome (IRP Rev I)
Human Research Program Gaps: (1) SANS-101:Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight (IRP Rev M)
Task Description: Veno-constrictive thigh cuffs (VTC) are a mechanical countermeasure capable of reducing headward fluid shifts in both ground-based and spaceflight studies, and thus, may be a countermeasure against development of the spaceflight associated neuro-ocular syndrome (SANS). In addition, VTC are at a high technical readiness level (TRL) and are compact and lightweight, making them compatible with the spaceflight operations environment. Here, we propose to investigate the effectiveness of VTC for mitigating spaceflight-induced headward fluid shifts in crewmembers before and during spaceflight missions to the International Space Station (ISS) using advanced imaging and physiological assessments. VTC will be used continuously, up to six hours with intermittent measures during this session, allowing us to characterize the temporal profile of this candidate countermeasure.

Specific Aim: Determine the efficacy of veno-constrictive thigh cuff application to mitigate a spaceflight-induced headward fluid shift. We hypothesize that a VTC countermeasure will temporarily reverse or attenuate spaceflight-induced ocular and cardiovascular changes. In addition, use of VTC for a longer duration than was used with the Chibis lower body negative pressure (LBNP) device during the Fluid Shifts study will allow us to investigate what role the duration of exposure has on our outcome variables.

Rationale for HRP Directed Research: This research is directed because it contains highly constrained research. This study will determine the ability of veno-constrictive thigh cuffs (VTC) application for varying durations to mitigate the weightlessness-induced headward fluid shift during spaceflight for the purpose of evaluating this device as a countermeasure for Spaceflight Associated Neuro-ocular Syndrome (SANS). The effects of varying durations of continuous VTC usage (30 minutes, 3 hours, and 6 hours) on ocular and cardiovascular variables will be investigated. This proposed study will help determine the potential efficacy of VTC to mitigate the cephalad fluid shift that is hypothesized to be the primary initiating factor to SANS. The VTC countermeasure technique is low-mass, portable, simple to use and may be used for extended durations while working in an operational spaceflight environment. The investigator team has the required expertise to conduct this research and has experience from a ground study led by this team in 33 subjects who wore these VTC for up to ~2 hours while supine at rest. An updated VTC and microfiber sleeve have been developed and tested in these ground-based studies.

Research Impact/Earth Benefits:

Task Progress & Bibliography Information FY2021 
Task Progress: New project for FY2021.

Bibliography Type: Description: (Last Updated: 12/13/2021)  Show Cumulative Bibliography Listing
 
 None in FY 2021