Responsible Center: NASA JSC
Grant Monitor: Stenger, Michael
Center Contact: 281-483-1311 michael.b.stenger@nasa.gov
Unique ID: 10966
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Solicitation / Funding Source: 2013-14 HERO NNJ13ZSA002N-ILSRA. International Life Sciences Research Announcement
Grant/Contract No.: 80NSSC19K1666 ; Internal Project ; NNX16AH78G
Project Type: FLIGHT
Flight Program: ISS
TechPort: No |
No. of Post Docs: 0
No. of PhD Candidates: 0
No. of Master's Candidates: 0
No. of Bachelor's Candidates: 0
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No. of PhD Degrees: 0
No. of Master's Degrees: 0
No. of Bachelor's Degrees: 0
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Human Research Program Elements: |
(1) HHC:Human Health Countermeasures
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Human Research Program Risks: |
(1) SANS:Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
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Human Research Program Gaps: |
(1) SANS-101:Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight. (2) SANS-102:Determine the relationship between the fluid shifts-induced ocular changes and fluid shifts in the CNS, including whether elevated intracranial pressure or brain edema play a role.
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Flight Assignment/Project Notes: |
NOTE: End date changed to 7/5/2021 per R. Schulte/HRP HHC element, due to PI move to KBR/NASA JSC management (Ed., 12/15/21)
NOTE: End date changed to 9/02/2025 per NSSC and R. Schulte/HRP (Ed., 7/14/2020)
NOTE: End date changed to 1/1/2026; note also with PI move to imec USA-Florida, PI's 3 projects were combined into one grant, 80NSSC19K1666 ; however, reporting will be required individually, per HRP (Ed., 11/4/19)
NOTE: End date changed to 9/30/2025 per HRP (Ed., 11/19/18) |
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Task Description: |
There is a clear need to investigate whether there is an association between intracranial pressure (ICP) increase and the Visual Impairment and Intracranial Pressure (VIIP) syndrome [Ed. note July 2020: now referred to as Spaceflight Associated Neuro-ocular Syndrome (SANS)]. The Non-Invasive ICP Framework (NICF) is a general approach for inferring ICP using noninvasive signals that are related to ICP. Leveraging multimodal noninvasive data from crew members to be collected in planned longitudinal experiments in flight will significantly improve the accuracy of this noninvasive ICP measurement tool. In addition, we will evaluate biomarkers in blood and urine of crew members, with the aim of investigating the molecular bases and genetic predisposition of developing VIIP syndrome. Overall, this study proposes the use of noninvasive measures plus biomarker discovery and validation as input to build a predictive model that will inform the likelihood of a given crew member of developing vision/neurological complications post flight. |
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Research Impact/Earth Benefits: |
Investigating the propensity and molecular mechanisms associated with ICP increase in microgravity will yield valuable information applicable to similar conditions on Earth, contributing to the knowledge of why conditions such as idiopathic intracranial hypertension develop, and how to manage elevated ICP. Moreover, the improvement of the non-invasive algorithm for ICP estimation will be of utmost importance for the diagnosis and management of neurologic conditions with high ICP and traumatic brain injury. |