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Task Book: Biological & Physical Sciences Division and Human Research Program
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Project Title:  Cardiovascular Responses to Simulated Spaceflight: Molecular Signatures and Surrogate Outputs to Measure CVD Risk Reduce
Fiscal Year: FY 2021 
Division: Human Research 
Research Discipline/Element:
HRP SR:Space Radiation
Start Date: 01/28/2021  
End Date: 01/27/2023  
Task Last Updated: 03/08/2021 
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Principal Investigator/Affiliation:   Tahimic, Candice Ginn Ph.D. / University of North Florida 
Address:  Department of Biology 
1 UNF Drive 
Jacksonville , FL 32224 
Email: c.tahimic@unf.edu 
Phone: 650-604-1743  
Congressional District:
Web:  
Organization Type: UNIVERSITY 
Organization Name: University of North Florida 
Joint Agency:  
Comments: PI moved to University of North Florida in fall 2020; previously at NASA Ames Research Center 
Co-Investigator(s)
Affiliation: 
Goukassian, David  M.D., Ph.D. ICAHN School of Medicine at Mount Sinai 
Ronca, April  Ph.D. NASA Ames Research Center 
Project Information: Grant/Contract No. 80NSSC21K0548 
Responsible Center: NASA JSC 
Grant Monitor: Elgart, Robin  
Center Contact: 281-244-0596 (o)/832-221-4576 (m) 
shona.elgart@nasa.gov 
Solicitation / Funding Source: 2019 HERO 80JSC019N0001-FLAGSHIP & OMNIBUS: Human Research Program Crew Health. Appendix A&B 
Grant/Contract No.: 80NSSC21K0548 
Project Type: GROUND 
Flight Program:  
TechPort: No 
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Human Research Program Elements: (1) SR:Space Radiation
Human Research Program Risks: (1) CVD:Risk of Spaceflight Induced Cardiovascular Disease (IRP Rev L)
(2) Immune:Risk of Adverse Health Event Due to Altered Immune Response (IRP Rev F)
Human Research Program Gaps: (1) CVD-102:Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease (IRP Rev L)
(2) CVD-103:To determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease (IRP Rev L)
(3) IM-101:Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness (IRP Rev L)
Task Description: In this ground-based rodent study, we aim to systematically define molecular signatures of cardiovascular performance across doses of acute simulated galactic cosmic radiation (Five-ion GCR) at early and late timepoints post-exposure. We also will determine the contribution of biological sex and the combined effects of GCR and microgravity on clinically relevant and emerging measures of cardiovascular health. We hypothesize that exposure to space radiation alone or in combination with microgravity results in early and late changes in the structure, transcriptome, redox signaling, and cytokine milieu of cardiovascular tissue, some of which have known links to decreased performance, aging, and increased cardiovascular disease (CVD) risk. We further posit that other less invasive clinically relevant measures of immune, behavior, and neuromotor function will be informative towards extrapolating the effects of deep space missions on human cardiovascular health. To achieve the project goals and test the hypothesis, we will take advantage of a rare tissue sharing opportunity from a recently funded Human Research Program (HRP) study. The experiment design of this funded investigation includes a GCR dosing study on crew age-matched female and male mice (6 months old) as well as combined exposure study with simulated microgravity. A comprehensive panel of outcomes will be assessed in the funded study and includes measures of immune health, brain molecular and structural changes, behavior, anxiety, cognition, and neuromotor function. Our proposed approach is to measure clinically relevant indicators of cardiovascular performance and perform transcriptomic profiling by RNAseq to determine dose and time-dependency of cardiovascular responses. To further facilitate extrapolation of results to humans, rodent RNAseq data will be compared to publicly available human RNAseq datasets from aging and CVD progression studies. The results from analysis of rodent cardiovascular tissue also will be compared to corresponding blood data to link immune and cardiovascular changes. Further, cardiovascular findings will be interpreted in light of behavioral testing results to gain insight on any relationships between cardiovascular outcomes and changes in neuromotor, anxiety levels, and cognitive performance. The significance/impact of this study is that it contributes to increased understanding on the mechanisms of degenerative changes in cardiovascular tissue and the clinical endpoints they suggest. This study also is expected to provide insight on the latency period for radiation-induced cardiovascular changes and any sex differences in these outcomes. Lastly, our findings are expected to generate testable hypotheses for the development of countermeasures and less invasive surrogate biomarkers to monitor cardiovascular health in-flight and after return.

Research Impact/Earth Benefits:

Task Progress & Bibliography Information FY2021 
Task Progress: New project for FY2021.

Bibliography Type: Description: (Last Updated: )  Show Cumulative Bibliography Listing
 
 None in FY 2021