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Task Book: Biological & Physical Sciences Division and Human Research Program
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Project Title: Human Multi-Tissue Platform to Study Effects of Space Radiation and Countermeasures
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Principal Investigator/Affiliation: Vunjak-Novakovic, Gordana Ph.D. / Columbia University
Department of Biomedical Engineering and Medicine
622 West 168th Street, VC12-234
New York , NY 10032
Amundson, Sally Ph.D.
Brenner, David Ph.D.
Garty, Guy Ph.D.
Hibshoosh, Hanina Ph.D.
Shuryak, Igor Ph.D.
Leong, Kam Ph.D.
Solicitation / Funding Source:
2020 TRISH Space Radiation Solicitation TSRAD-2020. Translational Research Institute for Space Health (TRISH) Human-Based Models to Study Effects of Space Radiation and Countermeasures
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NOTE: End date changed per E. Urquieta/TRISH (Ed., 8/19/21)
The exact effects of space radiation, a potentially serious risk encountered during prolonged missions to Moon and Mars (“red risk”), are still uncertain. There is a compelling need to better understand the safety thresholds and mechanisms of various types of tissue/cell/DNA damage, and to develop safe and effective radiation countermeasures for extended space travel. This proposal is to implement an already established multi-tissue platform to study the effects and mechanisms of space radiation and develop effective countermeasures for long missions. Over the last 8 years, we have bioengineered multiple human tissues starting from induced pluripotent stem cells (iPSCs) (heart, liver, bone, bone marrow, skin, sensory neurons, motor neurons, skeletal muscle, and midbrain). These tissues are matured and physiologically connected into an “organs on a chip” platform by vascular perfusion containing immune cells. With the addition of strong expertise in radiation biology, we collected preliminary data for the effects of photon and neutron radiation on sensory neurons, heart muscle, vascular endothelium, and bone marrow. Notably, the use of iPSCs allows individualized studies (e.g., for a specific astronaut). We now propose a radiation research platform consisting of four tissues: bone marrow (acute damage target), heart muscle (delayed damage target), liver (depo of granulocyte colony-stimulating factor (G-CSF)), and vascular perfusion with circulating cells. We further propose to evaluate an advanced nanoparticle-based modality for sustained delivery of G-CSF (a hematopoiesis stimulating factor) with oral delivery, or transactivation of the endogenous G-CSF gene for prolonged protection. These countermeasures will be tested against acute and fractionated high-linear energy transfer (LET) neutrons, simulated galactic cosmic rays, and photons (controls). We will validate the platform using iPSCs from healthy males and females and benchmark the collected data against known whole organism outcomes. The project will be milestone-driven and is expected to deliver a radically new approach enabling studies of space radiation damage and countermeasures.
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Task Progress & Bibliography Information FY2021
New project for FY2021.
Description: (Last Updated: )
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None in FY 2021
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