Responsible Center: NASA JSC
Grant Monitor: Stenger, Michael
Center Contact: 281-483-1311 michael.b.stenger@nasa.gov
Unique ID: 12198
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Solicitation / Funding Source: 2017-2018 HERO 80JSC017N0001-BPBA Topics in Biological, Physiological, and Behavioral Adaptations to Spaceflight. Appendix C
Grant/Contract No.: Internal Project
Project Type: FLIGHT
Flight Program:
TechPort: No |
No. of Post Docs: 0
No. of PhD Candidates: 0
No. of Master's Candidates: 0
No. of Bachelor's Candidates: 0
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No. of PhD Degrees: 0
No. of Master's Degrees: 0
No. of Bachelor's Degrees: 0
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Human Research Program Elements: |
(1) HHC:Human Health Countermeasures
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Human Research Program Risks: |
(1) Aerobic:Risk of Reduced Physical Performance Capabilities Due to Reduced Aerobic Capacity (2) Muscle:Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance
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Human Research Program Gaps: |
(1) CV2:What is VO2max in-flight and immediately post-flight? (2) M2:Characterize in-flight and post-flight muscle performance. (3) M23:Determine if factors other than unloading contribute to muscle atrophy during space flight.
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Flight Assignment/Project Notes: |
NOTE: End date changed to 6/6/2021 per change in PI per HHC/HRP (Ed., 9/20/21) |
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Task Description: |
Quantification of astronauts' changes in cardiorespiratory fitness and muscle performance and size in parallel with monitoring of pre and in-flight lifestyle habits (i.e., exercise training, nutritional intake, and sleep patterns) is needed to develop countermeasures and technologies for monitoring and mitigating crew health and performance risks during exploration class missions. The research proposed herein will temporally profile changes in astronauts' cardiorespiratory fitness and muscle mass, strength, and endurance over the course of spaceflight missions ranging from 2 months, 6 months, and up to 1 year in duration. Additionally, a statistical based extrapolation will provide predictions for changes associated with exploration missions 2-3 years in duration. To accomplish these objectives, lower and upper body muscle strength, power, and endurance will be measured using a well validated test battery consisting of leg extension, leg press, isokinetic, bench press tests, and isometric mid-thigh pull test. Muscle size will be assessed pre, in, and post-flight using well validated magnetic resonance imaging (MRI) and ultrasound imaging techniques. Cardiorespiratory fitness and related parameters will be tested pre, in, and post-flight using traditional VO2peak test and critical power test protocols paired with non-invasive assessments of oxygen consumption, cerebral and muscle oxygenation and perfusion. Ambulatory and in-flight exercise, nutrition, and sleep will be monitored using a variety of commercial technologies and in-flight assessment tools. This proposal specifically addresses the temporal effects of spaceflight on changes in cardiorespiratory fitness and muscle function, both critical parameters in maintaining the ability to perform mission critical tasks and enabling safe human space exploration beyond low Earth orbit. Integration of data collected during the pre and in-flight periods will lead to a better understanding of how to optimize exercise and non-exercise countermeasures to maintain crew health, safety, and performance during the exploration era.
NOTE: Project ended June 2021 and continues with new Principal Investigator, Dr. Eric Rivas. |
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Research Impact/Earth Benefits: |
It is well established exercise has many health benefits. This research will improve our understanding about the variability fitness improvements and how they change over time. Understanding this will improve exercise prescriptions for athletic and clinical populations on Earth. |