Human exploration of the deep solar system will necessitate plant growth for food production, which requires understanding plant growth in various gravity levels. The objectives of this project are predicting biomass production in different ventilation settings and defining the lowest adequate ventilation for optimal plant growth, by performing local studies of leaf gas exchanges. It will expand on results obtained in the past in parabolic flight and International Space Station (ISS) experiments, which have shown the effects of low ventilation and low gravity on gas exchanges at the leaf surface and photosynthesis. The methodology combines the development and validation of a mechanistic model of plant growth, computational fluid dynamics simulations, and experiments in different time frames. Expected results are to obtain a physically and biologically structured model of plant growth in reduced gravity environments, at least validated in Earth’s conditions.