The NASA Task Book

Responsible Center: TRISH Grant Monitor: Center Contact: Unique ID: 12372	Solicitation / Funding Source: TRISH--Focused Investigations Grant/Contract No.: NNX16AO69A-FIP0016 Project Type: GROUND Flight Program: TechPort: Yes	No. of Post Docs: 0 No. of PhD Candidates: 2 No. of Master's Candidates: 0 No. of Bachelor's Candidates: 0	No. of PhD Degrees: 0 No. of Master's Degrees: 0 No. of Bachelor's Degrees: 0

Human Research Program Elements:	None

Human Research Program Risks:	None

Human Research Program Gaps:	None

Task Description:	Focused Investigation Project The primary goal of this project is to characterize the impact of acute ionizing radiation (at levels that mimic deep space exploration) on the health and function of a human bone marrow using a microphysiological system model of human marrow (“bone marrow-on-a-chip” or BMoaC). The high significance of this project is derived from the unique and potentially dangerous levels of ionizing radiation exposure for astronauts on deep space missions, and the highly radio-sensitive features of human bone marrow, in particular the hematopoietic stem cell. Recent reports in simple monolayer culture systems suggest that both the hematopoietic stem cells (HSCs) and the supporting stromal cells (e.g., mesenchymal stem cell, MSC) are acutely effected by ionizing radiation which not only disrupts hematopoiesis, but also increases the incidence of leukemias. Specific Aim: Determine a dose-response curve between ionizing radiation (proton) and normal biological function of human bone marrow (leukocyte production) using a microphysiological system model of human bone marrow.

Research Impact/Earth Benefits:	The potential impact of the research lies in the use of a human bone marrow model, and the demonstration that the production and release of CD15+ (neutrophils) cells may be quite sensitive to doses that exceed 1 Gy. This is relevant as 1 Gy is the anticipated dose to astronauts on a mission to Mars and back.

Task Progress & Bibliography Information FY2020

Task Progress:

The primary goal of this project is to characterize the impact of acute ionizing radiation (at levels that mimic deep space exploration) on the health and function of a human bone marrow using a microphysiological system model of human marrow (bone marrow-on-a-chip or BMoaC). The high significance of this project is derived from the unique and potentially dangerous levels of ionizing radiation exposure for astronauts on deep space missions, and the highly radio-sensitive features of human bone marrow, in particular the hematopoietic stem cell. Recent reports in simple monolayer culture systems suggest that both the hematopoietic stem cells (HSC) and the supporting stromal cells (e.g., mesenchymal stem cell, MSC) are acutely effected by ionizing radiation which not only disrupts hematopoiesis, but also increases the incidence of leukemias.

Specific Aim: Determine a dose-response curve between ionizing radiation (proton) and normal biological function of human bone marrow (leukocyte production) using a microphysiological system model of human bone marrow.

Key Finding: We were able to demonstrate a dose-dependent decrease in CD45 and CD15 cells in the bone marrow over a dose range of 0.1 - 10 Gy. In addition, we observed a step change (decrease) in the release of CD15+ cells from the device for radiation doses exceeding 1.0 Gy.

Bibliography:

Description: (Last Updated: )

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None in FY 2020

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Project Title: Impact of Radiation Exposure on a 3D In Vitro Model of Human Bone Marrow

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Fiscal Year: FY 2019
Division: Human Research
Research Discipline/Element:
TRISH--TRISH

Start Date: 06/01/2019
End Date: 05/31/2020
Task Last Updated: 06/10/2019

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Principal Investigator/Affiliation: George, Steven Ph.D. / University of California, Davis

Address:

1 Shields Ave, Biomedical Engineering

Davis , CA 95616

Email: scgeorge@ucdavis.edu
Phone: 530-752-9978
Congressional District: 3
Web:

Organization Type: UNIVERSITY
Organization Name: University of California, Davis
Joint Agency:
Comments:

Project Information: Grant/Contract No. NNX16AO69A-FIP0016

Responsible Center: TRISH Grant Monitor: Center Contact: Unique ID: 12372	Solicitation / Funding Source: TRISH--Focused Investigations Grant/Contract No.: NNX16AO69A-FIP0016 Project Type: GROUND Flight Program: TechPort: Yes	No. of Post Docs: No. of PhD Candidates: No. of Master's Candidates: No. of Bachelor's Candidates:	No. of PhD Degrees: No. of Master's Degrees: No. of Bachelor's Degrees:

Human Research Program Elements:	None

Human Research Program Risks:	None

Human Research Program Gaps:	None

Task Description:	Focused Investigation Project The primary goal of this project is to characterize the impact of acute ionizing radiation (at levels that mimic deep space exploration) on the health and function of a human bone marrow using a microphysiological system model of human marrow (“bone marrow-on-a-chip” or BMoaC). The high significance of this project is derived from the unique and potentially dangerous levels of ionizing radiation exposure for astronauts on deep space missions, and the highly radio-sensitive features of human bone marrow, in particular the hematopoietic stem cell. Recent reports in simple monolayer culture systems suggest that both the hematopoietic stem cells (HSCs) and the supporting stromal cells (e.g., mesenchymal stem cell, MSC) are acutely effected by ionizing radiation which not only disrupts hematopoiesis, but also increases the incidence of leukemias. Specific Aim: Determine a dose-response curve between ionizing radiation (proton) and normal biological function of human bone marrow (leukocyte production) using a microphysiological system model of human bone marrow.

Research Impact/Earth Benefits:

Task Progress & Bibliography Information FY2019

Task Progress:

New project for FY2019.

Bibliography:

Description: (Last Updated: )

Show Cumulative Bibliography

None in FY 2019

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