Data collection is ongoing. We have currently enrolled/obtained consent for 6 subjects. In FY16, 4 subjects completed inflight data collection and 2 subjects completed ground data collection (1 subject has completed both ground and flight data collection). Data collection is still ongoing, with 2 subjects currently completing flight data collection and 3 subjects completing ground data collection. Thus far, we have collected more over 224 weeks of medication usage data (128 weeks inflight, 96 weeks on the ground); this includes over 5800 recorded medication entries (3049 inflight, 2717 ground), for an average of 961 entries per subject (453 inflight, 508 ground).
As data collection is still ongoing, we are unable to discuss detailed results. However, the medication usage data captured by Dose Tracker has already surpassed previous medication logging methods used for crewmembers, as measured by number of reports of medication use (Wotring, 2015). Although still early in the data collection phase, the inflight average of 453 medication entries per subject is over 38 times greater than the 12 medication entries per subject reported in crew medication records (Wotring, 2015). Additionally, Dose Tracker has collected 49 reports of no medication use (in a given week of data collection), providing positive confirmation that a crewmember is not using medications, instead of relying on the (possibly incorrect) assumption that no data equals no medication usage.
In FY16, we developed, tested, and released updated versions of both ground and flight Dose Tracker software, correcting several software bugs and renewing the iOS provisioning profile. Another provisioning profile update is planned for FY17. We met with JSC software developers and ExMC (Exploration Medical Capabilities) element staff to discuss future updates/changes to Dose Tracker, including improvements to the app’s usability and the potential transition to a web application.
Dose Tracker has currently paused recruiting new subjects at ExMC Element Scientists’s decision, in order to conduct a usability review of the software with crewmembers. We are currently conducting a review of the Dose Tracker application and exploring ways to improve the app’s usability, working with Kerry Maguire of ExMC. We plan to leverage this software update by also preparing a web application version of Dose Tracker, thus enabling use of any computer, rather than being restricted to iPad hardware. As a result of the pause in recruitment, 3 subjects who previously consented and had planned to started ground data collection in FY16 have now dropped the study.
At the request of a subject, we have started data sharing with their JSC flight surgeon, providing detailed weekly medication usage to the subject’s flight doctor within 5 days of data delivery to us.
In FY2016 we added new study staff at the Center for Space Medicine, BCM. Kyla Cook joined the Center for Space Medicine and will serve as project manager and data analyst for the Dose Tracker project.
Other Information & Materials:
• 1 abstract & presentation at HRP IWS 2016:
o V Wotring, K Cook, L Smith. Dose Tracker Application for Monitoring Crew Medication Usage, Symptoms, and Adverse Effects During Missions. NASA 2016 Human Research Program Investigators’ Workshop. February 8-11, 2016. Galveston, TX, USA.
o There have been no published articles in FY2016.
Wotring, V. E. (2015). Medication use by U.S. crewmembers on the International Space Station. Faseb j, 29(11), 4417-4423. http://dx.doi.org/10.1096/fj.14-264838