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Project Title:  Hybrid Training - A Sensory Stimulation Countermeasure for Long Duration Space Exploration Missions Expand All
Images: icon  Fiscal Year: FY 2019 
Division: Human Research 
Research Discipline/Element:
HFBP:Human Factors & Behavioral Performance (IRP Rev H) 
Start Date: 04/19/2016  
End Date: 03/31/2020  
Task Last Updated: 02/22/2019 
Download report in PDF pdf
Principal Investigator/Affiliation:   Basner, Mathias  M.D., Ph.D. / University of Pennsylvania 
Address:  Dept. of Psychiatry, Div. of Sleep and Chronobiology 
423 Service Dr, 1013 Blockley Hall 
Philadelphia , PA 19104-4209 
Email: basner@mail.med.upenn.edu 
Phone: 215-573-5866  
Congressional District:
Web:  
Organization Type: UNIVERSITY 
Organization Name: University of Pennsylvania 
Comments:  
Key Personnel Changes / Previous PI: N/A
Co-Investigator(s) / Affiliation:  Dinges, David  Ph.D./ University of Pennsylvania  Gur, Ruben  Ph.D./ University of Pennsylvania  Stahn, Alexander  Ph.D./ University of Pennsylvania 
Project Information: Grant/Contract No. NNX16AI53G 
Responsible Center: NASA JSC 
Grant Monitor: Williams, Thomas  
Center Contact: 281-483-8773 
thomas.j.williams-1@nasa.gov 
Solicitation: 2014-15 HERO NNJ14ZSA001N-MIXEDTOPICS. Appendix E: Behavioral Health & Human Health Countermeasures Topics 
Grant/Contract No.: NNX16AI53G 
Project Type: GROUND  
No. of Post Docs:
No. of PhD Candidates:
No. of Master's Candidates:
No. of Bachelor's Candidates:
No. of PhD Degrees:
No. of Master's Degrees:
No. of Bachelor's Degrees:
Human Research Program Elements: (1) HFBP:Human Factors & Behavioral Performance (IRP Rev H)
Human Research Program Risks: (1) Bmed:Risk of Adverse Behavioral Conditions and Psychiatric Disorders
Human Research Program Gaps: (1) BMed01:We need to identify and validate countermeasures that promote individual behavioral health and performance during exploration class missions (IRP Rev F)
Task Description: This proposal addresses the risk of Adverse Behavioral Conditions and Psychiatric Disorders, and the need to identify and validate countermeasures and effective methods for modifying the habitat/vehicle environment that promote individual behavioral health and performance during exploration class missions (BMed1, BMed7). We propose to investigate the efficacy of physical exercise (using a cycle ergometer) combined with an interactive virtual environment, i.e., Hybrid Training, as a countermeasure for augmenting sensory stimulation during long-duration space missions. This countermeasure will combine validated tools and VR (virtual reality) technologies in a new way to reveal the full potential of Hybrid Training, and take into account (a) key needs that fulfill sensory stimulation, (b) “hedonic adaptation”, i.e., a reduced affective response to stimuli with continued or repeated exposure, (c) delivery schedule, and (d) size, mass, and volume requirements. We plan to investigate a crew of N=9 during two 12-14 month Antarctic winter-over missions in Neumayer station (total N=18). We will investigate both immediate and long-term benefits of Hybrid Training. Our primary outcomes are neurostructural and neurofunctional changes assessed with fMRI, and cognitive performance assessed with the Cognition test battery and a virtual maze. We will also assess biochemical markers of stress and neuroplasticity, objective measures of sleep-wake rhythmicity and sleep structure, subjective symptom reports, and group cohesion with unobtrusive proximity measurements as additional outcomes that will provide insights into mechanisms and consequences of the observed structural and functional brain changes, and their reversibility by Hybrid Training. These data will be compared to historic controls from Neumayer station and other Antarctic stations (Concordia, Halley), space analog environments (e.g., Mars500), and the International Space Station (ISS). At the end of the project, we will have a much clearer understanding whether and to what extent the detrimental effects of ICE (isolated, confined, and extreme) environments on neuroplasticity and behavioral health can be mitigated by Hybrid Training.

 

Flight Assignment/Project Notes: NOTE: End date updated to 3/31/2020 per NSSC information (Ed., 11/12/19)

NOTE: End date updated to 10/31/2019 per NSSC information (Ed., 5/8/19)

NOTE: End date updated to 4/30/2019 per NSSC information (Ed., 1/23/19)

NOTE: Element change to Human Factors & Behavioral Performance; previously Behavioral Health & Performance (Ed., 1/17/17)

 

Research Impact/Earth Benefits: With the proposed work we will relevantly contribute to the goal of the Human Research Program (HRP) to provide human health and performance countermeasures, knowledge, technologies, and tools to enable safe, reliable, and productive human space exploration. More specifically, our findings, based on state-of-the-art neuroimaging technologies and on innovative, non-invasive, low burden, yet methodologically sound measurement technologies for cognitive, physiological, and crew cohesion outcomes, will relevantly contribute to the development of technologies to provide mission planners and system developers with strategies for monitoring and mitigating crew health and performance risks. These methodologies will also be useful for assessing subjects living in isolated, confined, and extreme environments on Earth.

 

Task Progress & Bibliography Information FY2019 
Task Progress: In the third year of the study (this reporting period), we accomplished the following:

1) Finalized data acquisition in Antarctica in the 2018 winter-over crew (N=9),

2) Performed post-mission data acquisition (including neuroimaging) at Charité Berlin in the 2018 winter-over crew in March 2019.

Data acquisition in Antarctica was finalized for both the 2017 and the 2018 winter-over crew according to plan. Adherence to the Hybrid Training protocol was satisfactory after the introduction of a compensation. Adherence to the other components of the protocol were high for an operational environment like Neumayer. Data analysis is underway, but we expect that we need a no-cost extension of the project to allow us enough time to thoroughly analyze the large amount of data collected before, during, and after the two winter-overs.

 

Bibliography Type: Description: (Last Updated: 10/09/2019)  Show Cumulative Bibliography Listing
 
Articles in Peer-reviewed Journals Boland EM, Rao H, Dinges DF, Smith RV, Goel N, Detre JA, Basner M, Sheline YI, Thase ME, Gehrman PR. "Meta-analysis of the antidepressant effects of acute sleep deprivation." J Clin Psychiatry. 2017 Sep/Oct;78(8):e1020-e1034. https://doi.org/10.4088/JCP.16r11332 ; PubMed PMID: 28937707 , Sep-2017
Project Title:  Hybrid Training - A Sensory Stimulation Countermeasure for Long Duration Space Exploration Missions Expand All
Images: icon  Fiscal Year: FY 2018 
Division: Human Research 
Research Discipline/Element:
HFBP:Human Factors & Behavioral Performance (IRP Rev H) 
Start Date: 04/19/2016  
End Date: 04/30/2019  
Task Last Updated: 02/16/2018 
Download report in PDF pdf
Principal Investigator/Affiliation:   Basner, Mathias  M.D., Ph.D. / University of Pennsylvania 
Address:  Dept. of Psychiatry, Div. of Sleep and Chronobiology 
423 Service Dr, 1013 Blockley Hall 
Philadelphia , PA 19104-4209 
Email: basner@mail.med.upenn.edu 
Phone: 215-573-5866  
Congressional District:
Web:  
Organization Type: UNIVERSITY 
Organization Name: University of Pennsylvania 
Comments:  
Key Personnel Changes / Previous PI: N/A
Co-Investigator(s) / Affiliation:  Dinges, David  Ph.D./ University of Pennsylvania  Gur, Ruben  Ph.D./ University of Pennsylvania  Stahn, Alexander  Ph.D./ University of Pennsylvania 
Project Information: Grant/Contract No. NNX16AI53G 
Responsible Center: NASA JSC 
Grant Monitor: Williams, Thomas  
Center Contact: 281-483-8773 
thomas.j.williams-1@nasa.gov 
Solicitation: 2014-15 HERO NNJ14ZSA001N-MIXEDTOPICS. Appendix E: Behavioral Health & Human Health Countermeasures Topics 
Grant/Contract No.: NNX16AI53G 
Project Type: GROUND  
No. of Post Docs:
No. of PhD Candidates:
No. of Master's Candidates:
No. of Bachelor's Candidates:
No. of PhD Degrees:
No. of Master's Degrees:
No. of Bachelor's Degrees:
Human Research Program Elements: (1) HFBP:Human Factors & Behavioral Performance (IRP Rev H)
Human Research Program Risks: (1) Bmed:Risk of Adverse Behavioral Conditions and Psychiatric Disorders
Human Research Program Gaps: (1) BMed01:We need to identify and validate countermeasures that promote individual behavioral health and performance during exploration class missions (IRP Rev F)
Task Description: This proposal addresses the risk of Adverse Behavioral Conditions and Psychiatric Disorders, and the need to identify and validate countermeasures and effective methods for modifying the habitat/vehicle environment that promote individual behavioral health and performance during exploration class missions (BMed1, BMed7). We propose to investigate the efficacy of physical exercise (using a cycle ergometer) combined with an interactive virtual environment, i.e., Hybrid Training, as a countermeasure for augmenting sensory stimulation during long-duration space missions. This countermeasure will combine validated tools and VR (virtual reality) technologies in a new way to reveal the full potential of Hybrid Training, and take into account (a) key needs that fulfill sensory stimulation, (b) “hedonic adaptation”, i.e., a reduced affective response to stimuli with continued or repeated exposure, (c) delivery schedule, and (d) size, mass, and volume requirements. We plan to investigate a crew of N=9 during two 12-14 month Antarctic winter-over missions in Neumayer station (total N=18). We will investigate both immediate and long-term benefits of Hybrid Training. Our primary outcomes are neurostructural and neurofunctional changes assessed with fMRI, and cognitive performance assessed with the Cognition test battery and a virtual maze. We will also assess biochemical markers of stress and neuroplasticity, objective measures of sleep-wake rhythmicity and sleep structure, subjective symptom reports, and group cohesion with unobtrusive proximity measurements as additional outcomes that will provide insights into mechanisms and consequences of the observed structural and functional brain changes, and their reversibility by Hybrid Training. These data will be compared to historic controls from Neumayer station and other Antarctic stations (Concordia, Halley), space analog environments (e.g., Mars500), and the International Space Station (ISS). At the end of the project, we will have a much clearer understanding whether and to what extent the detrimental effects of ICE (isolated, confined, and extreme) environments on neuroplasticity and behavioral health can be mitigated by Hybrid Training.

 

Flight Assignment/Project Notes: NOTE: End date updated to 4/30/2019 per NSSC information (Ed., 1/23/19)

NOTE: Element change to Human Factors & Behavioral Performance; previously Behavioral Health & Performance (Ed., 1/17/17)

 

Research Impact/Earth Benefits: With the proposed work we will relevantly contribute to the goal of the Human Research Program (HRP) to provide human health and performance countermeasures, knowledge, technologies, and tools to enable safe, reliable, and productive human space exploration. More specifically, our findings, based on state-of-the-art neuroimaging technologies and on innovative, non-invasive, low burden, yet methodologically sound measurement technologies for cognitive, physiological, and crew cohesion outcomes, will relevantly contribute to the development of technologies to provide mission planners and system developers with strategies for monitoring and mitigating crew health and performance risks. These methodologies will also be useful for assessing subjects living in isolated, confined, and extreme environments on Earth.

 

Task Progress & Bibliography Information FY2018 
Task Progress: In the past 12 months, we accomplished the following project milestones:

1) briefed N=9 subjects, obtained informed consent, and performed baseline data acquisition (including neuroimaging) at Charité Berlin for the 2018 winter-over crew,

2) finalized data acquisition in Antarctica in the 2017 winter-over crew,

3) performed post-mission data acquisition (including neuroimaging) at Charité Berlin in the 2017 winter-over crew in March 2018.

Overall, data acquisition rates and data quality were high for the 2017 winter-over crew.

 

Bibliography Type: Description: (Last Updated: 10/09/2019)  Show Cumulative Bibliography Listing
 
 None in FY 2018
Project Title:  Hybrid Training - A Sensory Stimulation Countermeasure for Long Duration Space Exploration Missions Expand All
Images: icon  Fiscal Year: FY 2017 
Division: Human Research 
Research Discipline/Element:
HFBP:Human Factors & Behavioral Performance (IRP Rev H) 
Start Date: 04/19/2016  
End Date: 04/18/2019  
Task Last Updated: 02/13/2017 
Download report in PDF pdf
Principal Investigator/Affiliation:   Basner, Mathias  M.D., Ph.D. / University of Pennsylvania 
Address:  Dept. of Psychiatry, Div. of Sleep and Chronobiology 
423 Service Dr, 1013 Blockley Hall 
Philadelphia , PA 19104-4209 
Email: basner@mail.med.upenn.edu 
Phone: 215-573-5866  
Congressional District:
Web:  
Organization Type: UNIVERSITY 
Organization Name: University of Pennsylvania 
Comments:  
Key Personnel Changes / Previous PI: N/A
Co-Investigator(s) / Affiliation:  Dinges, David  Ph.D./ University of Pennsylvania  Gur, Ruben  Ph.D./ University of Pennsylvania  MGuire, Sarah  Ph.D./ University of Pennsylvania  Stahn, Alexander  Ph.D./ University of Pennsylvania 
Project Information: Grant/Contract No. NNX16AI53G 
Responsible Center: NASA JSC 
Grant Monitor: Williams, Thomas  
Center Contact: 281-483-8773 
thomas.j.williams-1@nasa.gov 
Solicitation: 2014-15 HERO NNJ14ZSA001N-MIXEDTOPICS. Appendix E: Behavioral Health & Human Health Countermeasures Topics 
Grant/Contract No.: NNX16AI53G 
Project Type: GROUND  
No. of Post Docs:
No. of PhD Candidates:
No. of Master's Candidates:
No. of Bachelor's Candidates:
No. of PhD Degrees:
No. of Master's Degrees:
No. of Bachelor's Degrees:
Human Research Program Elements: (1) HFBP:Human Factors & Behavioral Performance (IRP Rev H)
Human Research Program Risks: (1) Bmed:Risk of Adverse Behavioral Conditions and Psychiatric Disorders
Human Research Program Gaps: (1) BMed01:We need to identify and validate countermeasures that promote individual behavioral health and performance during exploration class missions (IRP Rev F)
Task Description: This proposal addresses the risk of Adverse Behavioral Conditions and Psychiatric Disorders, and the need to identify and validate countermeasures and effective methods for modifying the habitat/vehicle environment that promote individual behavioral health and performance during exploration class missions (BMed1, BMed7). We propose to investigate the efficacy of physical exercise (using a cycle ergometer) combined with an interactive virtual environment, i.e., Hybrid Training, as a countermeasure for augmenting sensory stimulation during long-duration space missions. This countermeasure will combine validated tools and VR (virtual reality) technologies in a new way to reveal the full potential of Hybrid Training, and take into account (a) key needs that fulfill sensory stimulation, (b) “hedonic adaptation”, i.e., a reduced affective response to stimuli with continued or repeated exposure, (c) delivery schedule, and (d) size, mass, and volume requirements. We plan to investigate a crew of N=9 during two 12-14 month Antarctic winter-over missions in Neumayer station (total N=18). We will investigate both immediate and long-term benefits of Hybrid Training. Our primary outcomes are neurostructural and neurofunctional changes assessed with fMRI, and cognitive performance assessed with the Cognition test battery and a virtual maze. We will also assess biochemical markers of stress and neuroplasticity, objective measures of sleep-wake rhythmicity and sleep structure, subjective symptom reports, and group cohesion with unobtrusive proximity measurements as additional outcomes that will provide insights into mechanisms and consequences of the observed structural and functional brain changes, and their reversibility by Hybrid Training. These data will be compared to historic controls from Neumayer station and other Antarctic stations (Concordia, Halley), space analog environments (e.g., Mars500), and the International Space Station (ISS). At the end of the project, we will have a much clearer understanding whether and to what extent the detrimental effects of ICE (isolated, confined, and extreme) environments on neuroplasticity and behavioral health can be mitigated by Hybrid Training.

 

Flight Assignment/Project Notes: NOTE: Element change to Human Factors & Behavioral Performance; previously Behavioral Health & Performance (Ed., 1/17/17)

 

Research Impact/Earth Benefits: With the proposed work we will relevantly contribute to the goal of the Human Research Program (HRP) to provide human health and performance countermeasures, knowledge, technologies, and tools to enable safe, reliable, and productive human space exploration. More specifically, our findings, based on state-of-the-art neuroimaging technologies and on innovative, non-invasive, low burden, yet methodologically sound measurement technologies for cognitive, physiological, and crew cohesion outcomes, will relevantly contribute to the development of technologies to provide mission planners and system developers with strategies for monitoring and mitigating crew health and performance risks. These methodologies will also be useful for assessing subjects living in isolated, confined, and extreme environments on Earth.

 

Task Progress & Bibliography Information FY2017 
Task Progress: In the past 12 months, we accomplished the following project milestones:

1) received IRB (institutional review board) approval from all relevant institutions (NASA, University of Pennsylvania, Charité Berlin),

2) tested and selected the Hybrid Training equipment (Expresso HD Upright Bike),

3) purchased and prepared measurement equipment, shipped it, and installed it at Charité Berlin (for pre- and post-mission measurements) and at the Antarctic Neumayer station,

4) generated procedures for research subjects and wrote software for data harvesting,

5) briefed subjects, obtained informed consent, and performed baseline data acquisition (including neuroimaging) at Charité Berlin,

6) started data acquisition at Neumayer station in N=7 subjects that consented to take part in the study.

 

Bibliography Type: Description: (Last Updated: 10/09/2019)  Show Cumulative Bibliography Listing
 
 None in FY 2017
Project Title:  Hybrid Training - A Sensory Stimulation Countermeasure for Long Duration Space Exploration Missions Expand All
Images: icon  Fiscal Year: FY 2016 
Division: Human Research 
Research Discipline/Element:
HFBP:Human Factors & Behavioral Performance (IRP Rev H) 
Start Date: 04/19/2016  
End Date: 04/18/2019  
Task Last Updated: 05/17/2016 
Download report in PDF pdf
Principal Investigator/Affiliation:   Basner, Mathias  M.D., Ph.D. / University of Pennsylvania 
Address:  Dept. of Psychiatry, Div. of Sleep and Chronobiology 
423 Service Dr, 1013 Blockley Hall 
Philadelphia , PA 19104-4209 
Email: basner@mail.med.upenn.edu 
Phone: 215-573-5866  
Congressional District:
Web:  
Organization Type: UNIVERSITY 
Organization Name: University of Pennsylvania 
Comments:  
Co-Investigator(s) / Affiliation:  Dinges, David  Ph.D./ University of Pennsylvania  Gur, Ruben  Ph.D./ University of Pennsylvania  MGuire, Sarah  Ph.D./ University of Pennsylvania  Stahn, Alexander  Ph.D./ University of Pennsylvania 
Project Information: Grant/Contract No. NNX16AI53G 
Responsible Center: NASA JSC 
Grant Monitor:  
Center Contact:   
Solicitation: 2014-15 HERO NNJ14ZSA001N-MIXEDTOPICS. Appendix E: Behavioral Health & Human Health Countermeasures Topics 
Grant/Contract No.: NNX16AI53G 
Project Type: GROUND  
No. of Post Docs:  
No. of PhD Candidates:  
No. of Master's Candidates:  
No. of Bachelor's Candidates:  
No. of PhD Degrees:  
No. of Master's Degrees:  
No. of Bachelor's Degrees:  
Human Research Program Elements: (1) HFBP:Human Factors & Behavioral Performance (IRP Rev H)
Human Research Program Risks: (1) Bmed:Risk of Adverse Behavioral Conditions and Psychiatric Disorders
Human Research Program Gaps: (1) BMed01:We need to identify and validate countermeasures that promote individual behavioral health and performance during exploration class missions (IRP Rev F)
Task Description: This proposal addresses the risk of Adverse Behavioral Conditions and Psychiatric Disorders, and the need to identify and validate countermeasures and effective methods for modifying the habitat/vehicle environment that promote individual behavioral health and performance during exploration class missions (BMed1, BMed7). We propose to investigate the efficacy of physical exercise (using a cycle ergometer) combined with an interactive virtual environment, i.e., Hybrid Training, as a countermeasure for augmenting sensory stimulation during long-duration space missions. This countermeasure will combine validated tools and VR (virtual reality) technologies in a new way to reveal the full potential of Hybrid Training, and take into account (a) key needs that fulfill sensory stimulation, (b) “hedonic adaptation”, i.e., a reduced affective response to stimuli with continued or repeated exposure, (c) delivery schedule, and (d) size, mass, and volume requirements. We plan to investigate a crew of N=9 during two 12-14 month Antarctic winter-over missions in Neumayer station (total N=18). We will investigate both immediate and long-term benefits of Hybrid Training. Our primary outcomes are neurostructural and neurofunctional changes assessed with fMRI, and cognitive performance assessed with the Cognition test battery and a virtual maze. We will also assess biochemical markers of stress and neuroplasticity, objective measures of sleep-wake rhythmicity and sleep structure, subjective symptom reports, and group cohesion with unobtrusive proximity measurements as additional outcomes that will provide insights into mechanisms and consequences of the observed structural and functional brain changes, and their reversibility by Hybrid Training. These data will be compared to historic controls from Neumayer station and other Antarctic stations (Concordia, Halley), space analog environments (e.g., Mars500) and the International Space Station (ISS). At the end of the project, we will have a much clearer understanding whether and to what extent the detrimental effects of ICE environments on neuroplasticity and behavioral health can be mitigated by Hybrid Training.

 

Flight Assignment/Project Notes: NOTE: Element change to Human Factors & Behavioral Performance; previously Behavioral Health & Performance (Ed., 1/17/17)

 

Research Impact/Earth Benefits:

 

Task Progress & Bibliography Information FY2016 
Task Progress: New project for FY2016.

 

Bibliography Type: Description: (Last Updated: 10/09/2019)  Show Cumulative Bibliography Listing
 
 None in FY 2016