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Project Title:  Imaging and Serum Biomarkers to Predict and Identify Early Cardiac Injury from Radiation Exposure Reduce
Images: icon  Fiscal Year: FY 2018 
Division: Human Research 
Research Discipline/Element:
SR:Space Radiation 
Start Date: 08/23/2018  
End Date: 08/22/2021  
Task Last Updated: 11/13/2018 
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Principal Investigator/Affiliation:   Chung, Caroline  M.D. / University of Texas MD Anderson Cancer Center 
Address:  1515 Holcombe Blvd. 
Radiation Oncology and Diagnostic Imaging 
Houston , TX 77030 
Email: CChung3@mdanderson.org 
Phone: 713-745-5422  
Congressional District:
Web:  
Organization Type: UNIVERSITY 
Organization Name: University of Texas MD Anderson Cancer Center 
Joint Agency:  
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Co-Investigator(s)
Affiliation: 
Dabaja, Bouthaina  M.D. Co-PI: University of Texas MD Anderson Cancer Center 
Lopez-Mattei, Juan  M.D. University of Texas MD Anderson Cancer Center 
Swamique, Yusuf  M.D. University of Texas MD Anderson Cancer Center 
Gladish, Gregory  M.D. University of Texas MD Anderson Cancer Center 
Lin, Steven  M.D., Ph.D. Co-PI: University of Texas MD Anderson Cancer Center 
Gandhi, Saumil  M.D., Ph.D. University of Texas MD Anderson Cancer Center 
Layman, Rick  Ph.D. University of Texas MD Anderson Cancer Center 
Project Information: Grant/Contract No. 80NSSC18K1639 
Responsible Center: NASA JSC 
Grant Monitor:  
Center Contact:   
Solicitation: Directed Research 
Grant/Contract No.: 80NSSC18K1639 
Project Type: GROUND 
Flight Program:  
TechPort: No 
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Human Research Program Elements: (1) SR:Space Radiation
Human Research Program Risks: (1) Degen:Risk Of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure (IRP Rev F)
Human Research Program Gaps: (1) Degen02:What are the adverse outcome pathways associated with degenerative tissues changes in the cardiovascular, cerebrovascular, lens, immune, digestive, endocrine, and other tissue systems? What are the key events or hallmarks, their time sequence, and their associated biomarkers? (IRP Rev J)
 (2) Degen03:What are the progression rates and latency periods for radiation-induced degenerative diseases, and how do progression rates depend on age, sex, radiation type, or other physiological or environmental factors? (IRP Rev F)
 (3) Degen05:What quantitative procedures or theoretical models are needed to extrapolate molecular, cellular, or animal results to predict degenerative tissue risks in astronauts? How can human epidemiology data best support these procedures or models?
Flight Assignment/Project Notes: NOTE: Period of performance is now 8/23/2018-8/22/2021 per NSSC information since now goes through NSSC (Ed., 5/29/19)

Task Description: [ED. NOTE November 2018: Principal investigator (PI) changed to Dr. Caroline Chung, from Dr. Sarah Milgrom, due to Dr. Milgrom's change in institution. Period of performance also revised due to PI change; original period of performance was 7/18/2018-9/30/2021.]

Within the “Risk of Cardiovascular Disease and Other Degenerative Tissue Effects from Radiation Exposure and Secondary Spaceflight Stressors,” the gaps Degen-2 and -3 involve identification of adverse outcome pathways, progression rates and latency periods, and early surrogate markers for radiation-induced cardiovascular disease. To date, no tasks have included human radiotherapy cohorts to assess those parameters and identify biomarkers. The proposed work will acquire data on cardiovascular impairments and associated biomarkers observed in patients undergoing cardiac exposure to ionizing radiation with emphasis on non-invasive imaging modalities to quantify predictive changes linked to late impairment. Prompt identification of damage may enable interventions to prevent progression to cardiac dysfunction. Furthermore, study of cardiac changes that occur during and soon after radiotherapy would grant insight into the pathophysiology, which may lead to novel therapeutic interventions. The results may then be correlated with other studies performed in animals or in human cohorts with different types of radiation exposure such as astronauts. Research deliverables from this work will help close gaps Degen-2 and -3 as well as feed into countermeasure development and validation in animal studies with space radiation exposures. Results will also drive predictive model development (Degen-5). Specific Aims for the work include: 1) Assess for cardiac toxicity in patients treated with radiotherapy to the chest. 2) Assess for an association between 3D imaging findings suggestive of cardiac injury and radiation dosimetry. 3) Explore the association of radiation exposure with serum biomarker levels.

Research Deliverables

1. Evaluation of MRI as noninvasive imaging modality for detection of early indicators of cardiotoxicity following radiotherapy, compared with electrocardiograms.

2. Evaluation of serum markers and other cardiovascular parameters for detection of early indicators of cardiotoxicity following radiotherapy.

Rationale for HRP Directed Research: There is insufficient time for competitive solicitation through an NRA (NASA Research Announcement) due to Degen Risk accelerated schedule and milestone delivery. This work is also highly constrained research involving a pilot study with human radiotherapy cohorts and the advanced imaging expertise available at MD Anderson. The findings from this pilot study are expected to inform future solicited animal studies. Retrospective studies are not possible because the biomarkers are newly identified and are not yet fully validated, which this study will help to do.

Research Impact/Earth Benefits:

Task Progress & Bibliography Information FY2018 
Task Progress: New project for FY2018.

Bibliography Type: Description: (Last Updated: )  Show Cumulative Bibliography Listing
 
 None in FY 2018