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Project Title:  Space Flight Associated Changes in Astronauts' Plasma Derived miRNA Expression: Biomarker Identification Reduce
Fiscal Year: FY 2018 
Division: Human Research 
Research Discipline/Element:
TRISH--TRISH 
Start Date: 05/01/2018  
End Date: 07/31/2021  
Task Last Updated: 09/12/2018 
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Principal Investigator/Affiliation:   Goukassian, David A M.D., Ph.D. / Icahn School of Medicine at Mount Sinai 
Address:  Zena & Michael A. Weiner Cardiovascular Institute 
One Gustave L. Levy Place, Box 1030 
New York , NY 10029 
Email: david.goukassian@mssm.edu 
Phone: 617-480-3890  
Congressional District: 12 
Web:  
Organization Type: UNIVERSITY 
Organization Name: Icahn School of Medicine at Mount Sinai 
Joint Agency:  
Comments: NOTE: PI moved to Icahn School of Medicine at Mount Sinai from Temple University in October 2018.  
Co-Investigator(s)
Affiliation: 
Kishore, Raj  Ph.D. Temple University 
Coleman, Matthew  Ph.D. Institute for Advanced Study 
Project Information: Grant/Contract No. NNX16AO69A-FIP0005 
Responsible Center: TRISH 
Grant Monitor:  
Center Contact:   
Solicitation / Funding Source: TRISH--Focused Investigations 
Grant/Contract No.: NNX16AO69A-FIP0005 
Project Type: FLIGHT,GROUND 
Flight Program: Pre/Post Flight 
TechPort: No 
No. of Post Docs:  
No. of PhD Candidates:  
No. of Master's Candidates:  
No. of Bachelor's Candidates:  
No. of PhD Degrees:  
No. of Master's Degrees:  
No. of Bachelor's Degrees:  
Human Research Program Elements: None
Human Research Program Risks: None
Human Research Program Gaps: None
Flight Assignment/Project Notes: Shuttle specimen work

NOTE: End date changed to 7/31/2021 per E. Urquieta/TRISH (Ed., 4/28/21)

NOTE: End date changed to 10/31/2019 per E. Urquieta/TRISH (Ed., 5/23/19)

Task Description: Focused Investigation Project

This project aims to evaluate the potential impact of the space flight environment on the regulation of molecular pathways mediating cellular stress responses. We performed a first-of-its-kind pilot feasibility study to assess space flight-associated changes in exosomes derived from peripheral blood (PB) plasma collected 10 days before the launch (L -10) and the day of landing (R 0) from two astronauts who participated in STS-100 and STS-104 missions. Our preliminary pilot experiment results suggest that spaceflights may induce remarkable changes in the cargo of circulating plasma exosomes that may reflect alterations in multiple gene and protein pathways in various tissues and cells. This work represents a pilot/feasibility study to identify plasma exosomal miRNA as a source of blood derived epigenetic biomarker identification.

Research Impact/Earth Benefits:

Task Progress & Bibliography Information FY2018 
Task Progress: New project for FY2018.

Bibliography Type: Description: (Last Updated: 04/06/2021)  Show Cumulative Bibliography Listing
 
 None in FY 2018