The NASA Task Book

Responsible Center: TRISH Grant Monitor: Center Contact: Unique ID: 11869	Solicitation / Funding Source: TRISH--Synergy Grant/Contract No.: NNX16AO69A-SYN0003 Project Type: GROUND Flight Program: TechPort: No	No. of Post Docs: No. of PhD Candidates: No. of Master's Candidates: No. of Bachelor's Candidates:	No. of PhD Degrees: No. of Master's Degrees: No. of Bachelor's Degrees:

Human Research Program Elements:	None

Human Research Program Risks:	None

Human Research Program Gaps:	None

Task Description:	Synergy Project This project will design and characterize a novel Vertical Flow Paper-based Platform (VFP) built within a miniaturized “syringe-like” cartridge that will perform multiplexed detection of bio-agents and up to hundreds of biomarkers in small or large volumes of bodily fluids suitable for diagnosis in long space travel condition. This project will study bacterial agents (e.g., gut bacteria or other environmental exposure on the International Space Station-ISS), and also nucleic acid detection in order to develop a hybrid platform able to multiplex different types of biomarkers for enabling the diagnosis of multiple conditions. This is a synergy project with TRISH-funded Wake Forest University's project ("Novel Microfluidic Biomarker Detection Platforms to Monitor In Vivo Effects of Solar Particle Events and Galactic Cosmic Rays Radiation, Using Mice with Human Hematopoietic Systems ") by Principal Investigator (PI) Christopher Porada, Ph.D.

Research Impact/Earth Benefits:

Task Progress & Bibliography Information FY2019

Task Progress:

This project developed a platform able to measure the expression level of several genes at the same time. Interestingly, this platform, using vertical flow-based technology, provides new insights towards the development of a new point-of care technology to measure, simultaneously, expression of multiple biomarkers using an automated portable device integrating sample preparation, detection, and data analysis. Because of the miniaturization and potential automation, the platform will be suitable for the space environment: it limits weight and size into the space vehicle and provides a user-friendly interface for the crew without requiring any time-consuming training. With the exception of the use of small membranes, this platform does not contain solid single-use consumables and will be fully reusable in order to minimize supplies and waste in space. Our detection platform will use very small volumes of whole blood, but could also be ultimately used to quantify biomarkers in any types of biofluids such as urine, saliva, or sweat.

Bibliography:

Description: (Last Updated: 04/10/2024)

Show Cumulative Bibliography


Awards	Zenhausern F. "Special Prize Recipient, Funds Carlo of the Philanthropia Foundation, Geneva (Switzerland), for work on development of in vitro methods." Dec-2018

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Project Title: Development of a Vertical Flow Paper-based Platform (VFP) for Monitoring Health Outcomes in Inflight Condition

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Fiscal Year: FY 2018
Division: Human Research
Research Discipline/Element:
TRISH--TRISH

Start Date: 05/01/2018
End Date: 04/30/2019
Task Last Updated: 06/18/2018

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Principal Investigator/Affiliation: Zenhausern, Frederic Ph.D. / University of Arizona College of Medicine

Address:

Center for Applied NanoBioscience and Medicine
475 N 5th Street
Phoeniz , AZ 85004

Email: fzenhaus@email.arizona.edu
Phone:
Congressional District: 7
Web:

Organization Type: UNIVERSITY
Organization Name: University of Arizona College of Medicine
Joint Agency:
Comments:

Co-Investigator(s)
Affiliation:

Porada, Christopher Ph.D.

Wake Forest University School of Medicine

Project Information: Grant/Contract No. NNX16AO69A-SYN0003

Responsible Center: TRISH Grant Monitor: Center Contact: Unique ID: 11869	Solicitation / Funding Source: TRISH--Synergy Grant/Contract No.: NNX16AO69A-SYN0003 Project Type: GROUND Flight Program: TechPort: No	No. of Post Docs: No. of PhD Candidates: No. of Master's Candidates: No. of Bachelor's Candidates:	No. of PhD Degrees: No. of Master's Degrees: No. of Bachelor's Degrees:

Human Research Program Elements:	None

Human Research Program Risks:	None

Human Research Program Gaps:	None

Task Description:	Synergy Project This project will design and characterize a novel Vertical Flow Paper-based Platform (VFP) built within a miniaturized “syringe-like” cartridge that will perform multiplexed detection of bio-agents and up to hundreds of biomarkers in small or large volumes of bodily fluids suitable for diagnosis in long space travel condition. This project will study bacterial agents (e.g., gut bacteria or other environmental exposure on the International Space Station-ISS), and also nucleic acid detection in order to develop a hybrid platform able to multiplex different types of biomarkers for enabling the diagnosis of multiple conditions. This is a synergy project with TRISH-funded Wake Forest University's project ("Novel Microfluidic Biomarker Detection Platforms to Monitor In Vivo Effects of Solar Particle Events and Galactic Cosmic Rays Radiation, Using Mice with Human Hematopoietic Systems ") by Principal Investigator (PI) Christopher Porada, Ph.D.

Research Impact/Earth Benefits:

Task Progress & Bibliography Information FY2018

Task Progress:

New project for FY2018.

Bibliography:

Description: (Last Updated: 04/10/2024)

Show Cumulative Bibliography

None in FY 2018

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