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Project Title:  Efficacy of Orion Flywheel Exercise Training in Ambulatory Subjects Reduce
Images: icon  Fiscal Year: FY 2024 
Division: Human Research 
Research Discipline/Element:
HRP HHC:Human Health Countermeasures
Start Date: 01/01/2024  
End Date: 09/30/2026  
Task Last Updated: 07/16/2024 
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Principal Investigator/Affiliation:   Prejean, Brian J. Ph.D. / NASA Johnson Space Center 
Address:  2101 Nasa Pkwy 
B21, 1219J 
Houston , TX 77058-3607 
Email: brian.j.prejean@nasa.gov 
Phone: 281-483-0632  
Congressional District: 36 
Web:  
Organization Type: NASA CENTER 
Organization Name: NASA Johnson Space Center 
Joint Agency:  
Comments:  
Co-Investigator(s)
Affiliation: 
Amonette, William  Ph.D. University of Houston 
Chappell, Lori  M.S. KBR/NASA Johnson Space Center  
Marshall-Goebel, Karina  Ph.D. NASA Johnson Space Center 
Strock, Nicole  Ph.D. KBR/NASA Johnson Space Center 
Varanoske, Alyssa  Ph.D. KBR/NASA Johnson Space Center 
Project Information: Grant/Contract No. Internal Project 
Responsible Center: NASA JSC 
Grant Monitor:  
Center Contact:   
Unique ID: 16056 
Solicitation / Funding Source: Directed Research 
Grant/Contract No.: Internal Project 
Project Type: Ground 
Flight Program:  
TechPort: No 
No. of Post Docs:  
No. of PhD Candidates:  
No. of Master's Candidates:  
No. of Bachelor's Candidates:  
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No. of Bachelor's Degrees:  
Human Research Program Elements: (1) HHC:Human Health Countermeasures
Human Research Program Risks: (1) Aerobic:Risk of Reduced Physical Performance Capabilities Due to Reduced Aerobic Capacity
(2) Muscle:Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance
Human Research Program Gaps: None
Task Description: The Orion Flywheel (OFW) exercise device was selected to provide both resistance and aerobic (rowing ergometry) exercise for early Artemis missions to the Moon, lasting up to 21 days – which did not entail lunar surface extravehicular activities (EVAs). However, planned missions that will rely on the OFW as the sole exercise device have been extended to beyond 30 days in duration and will include lunar surface EVAs, which increase the performance demands on the crewmembers, and therefore the importance of the exercise device to protect against spaceflight-related deconditioning. The OFW provides speed-dependent exercise loads (known as isoinertial resistance) that are distinct from exercise loads provided by any other device that has been used in or developed for spaceflight, and only allows for a small number of resistance exercises. Other spaceflight exercise devices are designed to provide exercise loads that are comparable to well-studied, conventional gym-based exercise equipment (i.e., free weights, commercial cycles, rowing ergometers, and treadmills) and allow for a comprehensive range of resistance exercises. Additionally, the volume of OFW exercise that will be required of crewmembers on long-duration Artemis missions (30-60 minutes/day, 6 days/week) will exceed that used in previous ground-based flywheel studies. Therefore, understanding the efficacy of the novel OFW exercise device to be used as a comprehensive, stand-alone system will inform upcoming missing risk assessments and define future spaceflight exercise system designs.

NASA exercise scientists will collaborate with researchers from the University of Houston-Clear Lake to execute a controlled exercise intervention in free-living subjects to compare the OFW to conventional exercise equipment as well as to a "no-exercise". Subjects will be split into 3 exercise groups using 1of the three following exercise systems: the OFW only, free weights and a commercial rowing ergometer, or free weights plus a cycle and a treadmill. These exercise groups will follow an 8-week intervention, based on mission-like prescription concepts. A no-exercise control group will be included as a standard reference for adaptations to the exercise intervention across all exercise groups. Adaptations in functional performance, aerobic fitness, muscle strength and endurance, body composition, as well as metabolic and inflammatory responses, will be assessed between all study groups pre-intervention – and at the end of weeks 4 and 8 of the 8-week intervention – to discern any differences in these health and performance metrics across the study. Investigators hypothesize that limitations to the OFW as a comprehensive exercise system will be observed as decrements in upper body strength and functional task performance, and increases in inflammatory responses and subjective ratings of muscle soreness or discomfort in subjects using only the OFW for 8 weeks, compared to those using free weights and commercial aerobic exercise hardware. All subjects are expected to show improvements in outcome measures relative to the no-exercise control subjects.

In summary, understanding the adaptive response to exercise on this unique system will inform NASA human system risk recommendations for Lunar Design Reference Missions (DRMs), as well as exercise capability needs for future missions and vehicles. Near-term answers on OFW efficacy are critical, due to the expanding reliance of exploration programs on this custom device and the approach of crewed Artemis missions.

Rationale for HRP Directed Research: Highly constrained. Implementation of this training study will leverage planned or existing human-in-the-loop testing of the Orion flywheel device at University of Houston-Clear Lake to minimize impact on resources and budget. This study requires close coordination with internal NASA stakeholders and Flywheel project engineers. Thus, it is highly constrained and not well suited for acquisition via the normal solicitation processes.

Research Impact/Earth Benefits: The Orion Flywheel is currently the sole exercise countermeasure system that is planned to be available on early Artemis missions. Testing the efficacy of the Orion Flywheel for protecting physical performance is necessary to ensure that the device provides adequate aerobic and muscular stimulus over an extended use period.

Understanding the adaptive response to exercise on this novel system will inform risk assessments for early Artemis missions, as well as exercise capability needs for future missions and vehicles. Near-term answers on Orion Flywheel efficacy are critical, due to the expanding duration of use/reliance of exploration programs on this custom device and the approach of crewed Artemis missions.

Task Progress & Bibliography Information FY2024 
Task Progress: New Project for FY2024

Bibliography: Description: (Last Updated: ) 

Show Cumulative Bibliography
 
 None in FY 2024