Task Progress:
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During the 2 years of NSBRI First Award support, Dr. Lee made substantial progress in addressing the specific aims. Data was collected using Near-Infrared Spectroscopy (NIRS) on a 32-day National Institutes of Health (NIH) chronic sleep restriction (CSR) study and 8-day NSBRI acute sleep deprivation (ASD) study. We collected NIRS recordings from over 1000 cognitive performance testing sessions (from 9 participants) during the 32-day CSR study and over 150 testing sessions from 13 participants during an 8-day ASD protocol. We modified analysis software developed by Dr. Strangman for use in our experimental conditions. Assessment of the hemodynamic response to individual psychomotor vigilance task (PVT) trial presentation reveals after ~2.5 seconds, an increase in oxygenated hemoglobin, followed by return to baseline, while deoxygenated hemoglobin shows an inverse response. This pattern of hemodynamic response has been described in the visual cortex in previous studies using visual stimuli and demonstrates the operational success of the data collection.
For Specific Aim 1, NIRS data relative to melatonin phase (a circadian marker) were used to quantify the circadian rhythmicity in the hemodynamic response in the prefrontal cortex (PFC) in response to PVT presentation. We found a significant effect of circadian phase and length of time awake on PFC activation.
For Specific Aim 2, comparisons of hemodynamic responses to PVT from the beginning of the CSR protocol compared to responses at the end of the CSR protocol and between CSR and control participants were used to quantify the impact of CSR on brain activation in the PFC. We did not find a significant effect of CSR on PFC activation.
For Specific Aim 3, the PFC response and PVT lapses were analyzed between baseline and non-baseline days to identify a relationship between PFC activation and PVT performance. When PFC activation was lower than baseline, we found a significantly higher relative risk of PVT lapses in the same session.
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Abstracts for Journals and Proceedings
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Lee ML, Howard ME, Horrey WJ, Liang Y, Anderson C, Shreeve M, O’Brien C, Czeisler CA. "Drowsiness, impaired driving performance and critical driving events among shift workers driving an actual motor vehicle after night shift work." SLEEP 2013—27th Associated Professional Sleep Societies LLC (APSS) Annual Meeting, Baltimore, MD, June 1-5, 2013. Sleep. 2013;36(Abstract Suppl):A63. Abstract 0167. http://www.journalsleep.org/Resources/Documents/2013AbstractSupplement.pdf , Jun-2013
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Abstracts for Journals and Proceedings
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Lee ML, Strangman GE, Hull JT, Kamath T, Rahman SA, Lockley SW, Lockhandwala J, Zhang Q, Czeisler C, Klerman EB. "Assessing the Impact of Chronic Sleep Restriction and Acute Sleep Deprivation on Performance-Associated Regional Brain Activation using Near Infrared Spectroscopy." SRBR 2014. 14th Biennial Meeting, Society for Research on Biological Rhythms (SRBR), Big Sky, Montana, June 14-18, 2014. Program and Abstracts. SRBR 2014. 14th Biennial Meeting, Society for Research on Biological Rhythms (SRBR), Big Sky, Montana, June 14-18, 2014. Abstract P10, p. 122. http://srbr.org/wp-content/uploads/2015/02/SRBR2014ShortProgramv4.pdf ; accessed 4/8/15. , Jun-2014
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Abstracts for Journals and Proceedings
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Lee ML, Strangman GE, Hull JT, Kamath T, Wang W, Rahman SA, Lockley SW, Ivkovic V, Zhang Q, Klerman EB. "Assessing the Impact of Chronic Sleep Restriction on Sleep and Performance-Associated Regional Brain Activation Using Near Infrared Spectroscopy." 2014 NASA Human Research Program Investigators’ Workshop, Galveston, TX, February 12-13, 2014. 2014 NASA Human Research Program Investigators’ Workshop, Galveston, TX, February 12-13, 2014. http://www.hou.usra.edu/meetings/hrp2014/pdf/3284.pdf ; accessed 5/21/15. , Feb-2014
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Abstracts for Journals and Proceedings
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Lee ML, Strangman GE, Hull JT, Rahman SA, Lockley SW, Ivkovic V, Zhang Q, Klerman EB. "Assessing the Impact of Chronic Sleep Restriction and Acute Sleep Deprivation on Performance-Associated Regional Brain Activation Using Near Infrared Spectroscopy." SLEEP 2014, 28th Annual Meeting of the Associated Professional Sleep Societies, Minneapolis MN, May 31-June 4, 2014. Sleep. 2014;37(Abstract Suppl):A82-A33. Abstract 0228. http://www.journalsleep.org/Resources/Documents/2014AbstractSupplement.pdf ; accessed 5/21/15. , Jun-2014
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Abstracts for Journals and Proceedings
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Lee ML, Zhang Q, Strangman GE, Klerman EB. "Assessing the Impact of Chronic Sleep Restriction on Sleep and Performance-Associated Regional Brain Activation Using Near Infrared Spectroscopy." 2013 NASA Human Research Program Investigators’ Workshop, Galveston, TX, February 12-14, 2013. 2013 NASA Human Research Program Investigators’ Workshop, Galveston, TX, February 12-14, 2013. , Feb-2013
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Articles in Peer-reviewed Journals
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Lee ML, Howard ME, Horrey WJ, Liang Y, Anderson C, Shreeve M, O’Brien C, Czeisler CA. "High risk of near-crash driving events following night-shift work." Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):176-81. https://doi.org/10.1073/pnas.1510383112 ; PMID: 26699470; PMCID: PMC4711869
[note reported previously in May 2015 as "Submitted"]
, Jan-2016
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Articles in Peer-reviewed Journals
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Liang Y, Horrey WJ, Howard ME, Lee ML, Anderson C, Shreeve MS, O'Brien CS, Czeisler CA. "Prediction of drowsiness events in night shift workers during morning driving.
" Accid Anal Prev. 2019 May;126:105-14. Epub 2017 Nov 7. https://doi.org/10.1016/j.aap.2017.11.004 ; PMID: 29126462 , May-2019
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Awards
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Lee M. (Michael Lee) "Runner-Up: Dr. David Watson Postdoctoral Fellow Poster Contest, February 2014." Feb-2014
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Awards
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Lee M. (Michael Lee) "SRS Abstract Meritorious Award. Sleep Research Society, June 2013." Jun-2013
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Books/Book Chapters
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de la Iglesia HO, Lee ML. "A time to wake, a time to sleep." in "Mechanisms of Circadian Systems in Animals and Their Clinical Relevance." Ed. R. Aguilar-Roblero, M. Díaz-Muñoz, M.L. Fanjul-Moles. New York, NY: Springer Publishing, 2015. p. 197-217. http://dx.doi.org/10.1007/978-3-319-08945-4_11 , Jan-2015
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Significant Media Coverage
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Lee ML, Howard M, Horrey W, Liang Y, Anderson C, Shreeve M. O'Brien C, Czeisler C. "Asleep at the Wheel ... and You Don't Even Know It! News coverage of this research on The Rachael Ray Show." News coverage of this research on The Rachael Ray Show. Aired May 15, 2013. http://www.rachaelrayshow.com/lifestyle/health/7879_Asleep_at_the_Wheel_and_You_Dont_Even_Know_It/ ; accessed 5/21/15., May-2013
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