Responsible Center: NASA JSC
Grant Monitor: Stenger, Michael
Center Contact: 281-483-1311 michael.b.stenger@nasa.gov
Unique ID: 14188
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Solicitation / Funding Source: 2019-2020 HERO 80JSC019N0001-HHCBPSR, OMNIBUS2: Human Health Countermeasures, Behavioral Performance, and Space Radiation-Appendix C; Omnibus2-Appendix D
Grant/Contract No.: 80NSSC21K0251
Project Type: GROUND
Flight Program:
TechPort: No |
No. of Post Docs: 0
No. of PhD Candidates: 0
No. of Master's Candidates: 0
No. of Bachelor's Candidates: 0
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No. of PhD Degrees: 1
No. of Master's Degrees: 0
No. of Bachelor's Degrees: 0
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Human Research Program Elements: |
(1) HHC:Human Health Countermeasures
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Human Research Program Risks: |
(1) Cardiovascular:Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
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Human Research Program Gaps: |
(1) CV-101:Determine whether long-duration weightlessness induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.
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Flight Assignment/Project Notes: |
NOTE: End date changed to 11/01/2024 per NSSC information (Ed., 1/13/24)
NOTE: End date changed to 11/12/2023 per NSSC information (Ed., 11/16/22)
NOTE: End date changed to 11/12/2022 per NSSC information (Ed., 11/18/21) |
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Task Description: |
The recent report of complete and partial thrombosis of the internal jugular vein in crew members on the International Space Station (ISS) raises concerns for the potential of life threatening pulmonary emboli. There appear to be very abnormal blood flow patterns in the internal jugular vein in zero gravity that may predispose to local thrombus formation. Given that the endothelium is uniquely sensitive to changes in the local flow/shear stress environment, the focus of this proposal is on the potential role of the endothelium in mediating localized thrombus formation. The purpose of this proposal is to identify changes in gene expression in venous endothelium exposed to the same flow patterns as those observed in the ISS crew members using isolated vein organ culture system. These studies will help us to develop a better understanding of the basic mechanisms responsible for thrombosis formation with the ultimate goal of potentially identifying biomarkers that would enable screening and risk stratification of crew members. |
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Research Impact/Earth Benefits: |
This work will help us to better understand the fundamental physiologic impact of altered flow patterns on the venous endothelium. In addition to allowing us to better understand the differences between venous and arterial endothelial responses, the work may have direct applications to helping us to understand the pathophysiology of venous disease. Finally, venous grafts are used in peripheral and coronary artery bypass surgery and we know that they have a limited, useful lifespan. Given that these segments are placed in a flow environment that is different from the natural flow environment, the work in this proposal may provide insight into how venous endothelium responds to non-physiologic flow stimuli. |