Task Progress:
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For all Aims, 4,565 animals have been irradiated or served as controls. 3,975 animals have completed the study. There are still 2 cohorts of animals under study those being the avasopasem treated unirradiated animals and the cohort irradiated with 1.5 Gy 137Cs and treated with avasopasem for a total of 483 mice remaining. 556 suspected lung tumors have been collected and roughly 240 have been sent to pathology for processing. 160 are ready for pathologic analysis to confirm and describe lung tumors in a blinded fashion. Interestingly, other non-cancer pathologies have been identified including hematologic ovarian cysts and tumors, and hepatosplenomegaly. Interestingly, survival of the 1.5 Gy 137Cs-irradiated cohort treated with avasopasem is higher than the cohort not treated with avasopasem although the p-value at this point is ~0.06. This avasopasem-treated cohort will continue until the termination point. The avasopasem-treated unirradiated cohort will continue for another approximately 6 months.
Constraints: While lung tissue, lung masses and tumor.
Oral Presentations: 2023 NASA Human Research Program Investigators' Workshop (IWS), Galveston, Texas, February 7-9, 2023. Oral presentation by Sorour Hosseini. Is lung cancer risk after space radiation exposure higher in females than in males, and can SOD mimetic GC4419 act as a radiation countermeasure? S. Hosseini, Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas.
Hosseini S, Sishc BJ, Ramnarain D, Polsdofer EM, Story MD. 2023 American Association of Physicists in Medicine (AAPM) 65th Annual Meeting Houston, Texas. July 23-27, 2023. Oral presentation by Sorour Hosseini. Avasopasem manganese protects and mitigates radiation-induced lung fibrosis, reduces radiogenic lung cancers and extends survival in mice irradiated with either low LET or high LET radiations simulating the space environment.
Poster Presentations: Hosseini S, Polsdofer EM, Felix D, Nicholson J, Ding L-H, Wight-Carter M, Story MD. 2023 International Congress on Radiation Research (ICRR), Montreal, Canada, August 26-30, 2023. Poster presentation, Michael Story. Evaluating the potential of the SOD mimetic Avasopasem Manganese as a radiation countermeasure for space radiation-induced lung cancer.
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Abstracts for Journals and Proceedings
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Hosseini S, Sishc BJ, Ramnarain D, Polsdofer EM, Story MD. "Avasopasem manganese protects and mitigates radiation-induced lung fibrosis, reduces radiogenic lung cancers and extends survival in mice irradiated with either low LET or high LET radiations simulating the space environment." AAPM 2023. 65th Annual Meeting and Exhibition of the American Association of Physicists in Medicine, Houston, Texas, July 23-27, 2023. Abstracts. AAPM 2023. 65th Annual Meeting and Exhibition of the American Association of Physicists in Medicine, Houston, Texas, July 23-27, 2023. , Jul-2023
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